Long-term arterial pressure in spontaneously hypertensive rats is set by the kidney.

Objectives: We investigated whether arterial pressure in spontaneously hypertensive rats (SHR) can be normalized by a kidney graft from normotensive histocompatible donors. In addition, the effect of differential genetic predisposition to hypertension of recipients of an SHR kidney on the development of post-transplantation hypertension was studied.

Methods: SHR were transplanted with a kidney from congenic rats (BB.