An individualised 3D computational flow and particle model to predict the deposition of inhaled medicines - A case study using a nebuliser.

Background And Objective: Drug inhalation is generally accepted as the preferred administration method for treating respiratory diseases. To achieve effective inhaled drug delivery for an individual, it is necessary to use an interdisciplinary approach that can cope with inter-individual differences. The paper aims to present an individualised pulmonary drug deposition model based on Computational Fluid and Particle Dynamics simulations within a time frame acceptable for clinical use.

Anatomy matters: The role of the subject-specific respiratory tract on aerosol deposition - A CFD study.

The COVID-19 pandemic is one of the greatest challenges to humanity nowadays. COVID-19 virus can replicate in the host's larynx region, which is in contrast to other viruses that replicate in lungs only, i.e.

Risk Assessment of Infection by Airborne Droplets and Aerosols at Different Levels of Cardiovascular Activity.

Since end of 2019 the COVID-19 pandemic, caused by the SARS-CoV-2 virus, is threatening humanity. Despite the fact that various scientists across the globe try to shed a light on this new respiratory disease, it is not yet fully understood. Unlike many studies on the geographical spread of the pandemic, including the study of external transmission routes, this work focuses on droplet and aerosol transport and their deposition inside the human airways.

Can CFD establish a connection to a milder COVID-19 disease in younger people? Aerosol deposition in lungs of different age groups based on Lagrangian particle tracking in turbulent flow.

To respond to the ongoing pandemic of SARS-CoV-2, this contribution deals with recently highlighted COVID-19 transmission through respiratory droplets in form of aerosols. Unlike other recent studies that focused on airborne transmission routes, this work addresses aerosol transport and deposition in a human respiratory tract. The contribution therefore conducts a computational study of aerosol deposition in digital replicas of human airways, which include the oral cavity, larynx and tracheobronchial airways down to the 12th generation of branching.

Settling characteristics of nonspherical porous sludge flocs with nonhomogeneous mass distribution.

The paper reports on the development of an advanced Lagrangian particle tracking model of sludge flocs that takes into account its nonspherical shape, the internal porosity and permeability, as well as the nonhomogenous mass distribution. The floc shapes, sizes and free settling velocities are determined based on the experimental measurement of settling sludge flocs originating from a wastewater treatment plant. Based on the floc shape characterization, a prolate axisymmetric ellipsoid is selected as the modelled sludge particle.