Primary thyroid leiomyosarcoma with transvenous extension to the right atrium: a case report.

Background: Primary thyroid leiomyosarcoma (LMS) is a very rare tumour with less than 40 published cases yet. Direct metastatic extension into the great cervical veins and caval veins is extremely uncommon. Extension to the right heart has not yet been reported.

FireProtDB: database of manually curated protein stability data.

The majority of naturally occurring proteins have evolved to function under mild conditions inside the living organisms. One of the critical obstacles for the use of proteins in biotechnological applications is their insufficient stability at elevated temperatures or in the presence of salts. Since experimental screening for stabilizing mutations is typically laborious and expensive, in silico predictors are often used for narrowing down the mutational landscape.

["3P (Patient-Pulse-Prognosis) in heart failure" survey: focus on heart rate].

Background: The data on heart rate in chronic heart failure in the real-world practice in Slovakia are not sufficiently known. The objective of the "3P (Patient-Pulse-Prognosis) in heart failure" survey was to collect epidemiological data with particular emphasis on heart rate control in sinus rhythm.

Methods: The survey was performed by 162 cardiologists and internists.

Right ventricular systolic dysfunction and its prognostic value in heart failure with preserved ejection fraction.

Objective: The prognostic impact of right ventricular systolic dysfunction (RVSD) in heart failure (HF) with preserved ejection fraction (HFPEF) is not sufficiently understood. This pilot study evaluates the prevalence and prognostic impact of RVSD in HFPEF.

Methods: Ninety-five consecutive patients, admitted due to HF within one year were included and followed up for 12 months.

Can we predict clinical cardiotoxicity with cardiac biomarkers in patients after haematopoietic stem cell transplantation?

The long-term prognosis of patients after haematopoietic stem cell transplantation (HSCT) has greatly improved. Cardiac complications represent unresolved and potentially life-threatening conditions in these patients. We prospectively examined 37 consecutive patients with a median age of 28 years who underwent allogeneic HSCT.

Serial measurements of cardiac biomarkers in patients after allogeneic hematopoietic stem cell transplantation.

Background: Previous therapy with anthracyclines (ANT) and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT) represents a high risk for development of cardiotoxicity. The aim of this study was to assess subclinical myocardial damage after HSCT using echocardiography and cardiac biomarkers--high sensitive cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and to identify patients at risk of developing clinical cardiotoxicity.

Patients And Methods: Thirty-seven patients who were treated with allogeneic HSCT for hematologic diseases at median age of 28 years at time of HSCT were studied.

An unusual cause of recurrent syncope: Mediastinal lymphoma diagnosed with transesophageal echocardiography.

Non-Hodgkin's lymphoma (NHL) rarely presents initially with cardiac symptoms. In this case, its first symptom was a recurrent syncope. The diagnosis of mediastinal tumor was made with transesophageal echocardiography.