Publications by authors named "Juquan Yao"
Article Synopsis
- Calcification in pulmonary hypertension associated with left heart disease appears to be influenced by the interaction between RUNX2 and TAZ, which are key regulators in osteogenic processes.
- Significant vascular calcification was observed in both patients and rat models, with elevated levels of RUNX2 and TAZ.
- Inhibiting TAZ or RUNX2 effectively reduced vascular calcification and the progression of pulmonary hypertension in the rat model, suggesting potential therapeutic targets.
Pulmonary hypertension worsens outcome in left heart disease. Stiffening of the pulmonary artery may drive this pathology by increasing right ventricular dysfunction and lung vascular remodeling. Here we show increased stiffness of pulmonary arteries from patients with left heart disease that correlates with impaired pulmonary hemodynamics.
View Article and Find Full Text PDFPulmonary hypertension due to left heart disease (PH-LHD) is the most common form of PH, yet its pathophysiology is poorly characterized than pulmonary arterial hypertension (PAH). As a result, approved therapeutic interventions for the treatment or prevention of PH-LHD are missing. Medications used to treat PH in PAH patients are not recommended for treatment of PH-LHD, as reduced pulmonary vascular resistance (PVR) and increased pulmonary blood flow in the presence of increased left-sided filling pressures may cause left heart decompensation and pulmonary edema.
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