[Development of prodioxin ointment].

There was a purpose to create a composite ointment of proteolytic and antimicrobial activity, the formulation of which would contain the proteolytic enzyme procelan and the antimicrobial preparation with wide spectrum of action dioxidin. During the development of prodioxin ointment by means of biological experiments the optimal concentration of dioxidin was evaluated; it was 1 percent. The optimal dispersity value of dioxidin particles was estimated by dialysis through a semipermeable membrane.

[Development of technology of the enzyme preparation: procelan ointment].

When investigating the release of procelan from diphilic, hydrophobic and hydrophilic basis we determined that the best release of the active substance is from hydrophilic basis. The macrogolic base when compared with methylcellulosic one shows clearly expressed osmotic properties and therefore is more suitable as a base for ointments intended to treat suppurative wounds. This was confirmed by treatment of experimentally excited suppurative wounds on rabbits.