Leydig cells pyroptosis in testis mediates deoxynivalenol-induced male reproductive toxicity in mice.

Deoxynivalenol (DON) is a toxic secondary metabolite produced by Fusarium spp. It is widely distributed among various cereals and has attracted much attention as a potential health threat to humans and domestic animals. However, the effects of DON on the reproductive systems of mammals are still ambiguous.

Hesperidin Alleviates Hepatic Injury Caused by Deoxynivalenol Exposure through Activation of mTOR and AKT/GSK3β/TFEB Pathways.

Deoxynivalenol (DON) is a common agricultural mycotoxin that is chemically stable and not easily removed from cereal foods. When organisms consume food made from contaminated crops, it can be hazardous to their health. Numerous studies in recent years have found that hesperidin (HDN) has hepatoprotective effects on a wide range of toxins.

18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control.

Deoxynivalenol (DON), a widespread mycotoxin, represents a substantial public health hazard due to its propensity to contaminate agricultural produce, leading to both acute and chronic health issues in humans and animals upon consumption. The role of ferroptosis in DON-induced hepatic damage remains largely unexplored. This study investigates the impact of 18β-glycyrrhetinic acid (GA), a prominent constituent of glycyrrhiza, on DON hepatotoxicity and elucidates the underlying mechanisms.

Ferritinophagy Is Critical for Deoxynivalenol-Induced Liver Injury in Mice.

Deoxynivalenol (DON) contamination, pervasive throughout all stages of food production and processing, presents a significant threat to human health. The degradation of ferritin mediated by nuclear receptor coactivator 4 (NCOA4), termed ferritinophagy, plays a crucial role in maintaining iron homeostasis and regulating ferroptosis. This study aims to elucidate the role of ferritinophagy and ferroptosis in DON-induced liver injury.

Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1.

Deoxynivalenol (DON) is by far the most common mycotoxin contaminating cereal foods and feeds. Furthermore, cleaning up DON from contaminated cereal items is challenging. Low-dose DON consumption poses a danger to humans and agricultural animals.

Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice.

Atrazine (ATR) is a commercially available herbicide that is used worldwide. The intensive use of ATR poses potential risks to animals' and humans' health. Lycopene (LYC) is an anti-oxidative phytochemical that normalizes health hazards triggered by environmental factors.

Determination of norfloxacin in food by an enhanced spectrofluorimetric method.

Background: Using a norfloxacin (NFLX)-Nd -cetyltrimethylammonium bromide (CTAB) system for the detection of NFLX, a simple and sensitive method based on fluorescence enhancement was developed.

Results: In pH 7.0 buffer solution, NFLX reacted with Nd to form a complex, which resulted in fluorescence enhancement of NFLX, and the maximum emission peak shifted from 415 nm for NFLX to 450 nm for NFLX-Nd .

A sensitive "turn-on" fluorescent assay for quantification of ceftriaxone based on L-tryptophan-Pd(II) complex fluorophore.

Based on L-tryptophan-Pd(II) system, a sensitive and selective fluorimetric assay for the quantification of ceftriaxone (CTRX) had been developed. The experimental results showed that in pH 4.0 Britton-Robinson (BR) buffer medium, the fluorescence of L-tryptophan (L-Trp) (λex/λem=276 nm/352 nm) could be efficiently quenched by Pd(II).

Triple-wavelength overlapping resonance Rayleigh scattering method for facile and rapid assay of perfluorooctane sulfonate.

In the present study, a novel triple-wavelength overlapping resonance Rayleigh scattering (TWO-RRS) method had been well established to detect perfluorooctane sulfonate (PFOS). We found that crystal violet (CV) could react with PFOS to form 1:1 ion-association complex by electrostatic attraction and hydrophobic effect over a wide pH range (5.0∼11.