A novel complex coupling agent for enhancing the compatibility between collagen fiber and natural rubber: A utilization strategy for leather wastes.

Leather shavings are generated as solid waste in the leather industry and may cause environmental pollution if not disposed judiciously. These solid wastes, primarily composed of collagen fibers (CFs), can be recycled as biomass composites. However, CFs are incompatible with natural rubber (NR) due to its hydrophilicity.

dECM based dusal-responsive vascular graft with enzyme-controlled adenine release for long-term patency.

Rapid occlusion is the culprit leading to implantation failure of biological blood vessels. Although adenosine is a clinical-proven drug to overcome the problem, its short half-life and turbulent burst-release limit its direct application. Thus, a pH/temperature dual-responsive blood vessel possessed controllable long-term adenosine secretion was constructed based on acellular matrix via compact crosslinking by oxidized chondroitin sulfate (OCSA) and functionalized with apyrase and acid phosphatase.