Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling.

Background: Eurycomanone (EN) is a diterpenoid compound isolated from the roots of (). Previous studies have confirmed that can enhance bone regeneration and bone strength. We previously isolated and identified ten quassinoids from , and the result displayed that five aqueous extracts have the effects on promotion of bone formation, among whom EN showed the strongest activity.

Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms.

Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth retardation or even osteoporotic fractures. Children's bone growth is dependent on endochondral ossification of growth plate chondrocytes, and excessive GC can hinder the development of growth plate and longitudinal bone growth.

Anti-Osteogenic Effect of Danshensu in Ankylosing Spondylitis: An Study Based on Integrated Network Pharmacology.

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by abnormal bone metabolism, with few effective treatments available. Danshensu [3-(3,4-dihydroxy-phenyl) lactic acid) is a bioactive compound from traditional Chinese medicine with a variety of pharmacologic effects. In the present study, we investigated the pharmacologic effect and molecular mechanism of Danshensu in AS.