Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.

Background: Hyperoside (quercetin-3-O-β-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericum and Crataegus genera that reportedly exhibits an array of anti-inflammatory, antioxidant, and antitumor properties such that it has been used to treat various diseases. Whether it can serve as an effective treatment for chronic myeloid leukemia (CML) cells, however, has yet to be established. The present study was thus devised to assess the therapeutic effects of hyperoside on CML cells and to clarify the underlying mechanism of action.

Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells.

Vascular calcification is a complication that is frequently encountered in patients affected by atherosclerosis, diabetes, and chronic kidney disease (CKD), and that is characterized by the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). At present, there remains a pressing lack of any effective therapies that can treat this condition. The sodium-glucose transporter 2 (SGLT2) inhibitor dapagliflozin (DAPA) has shown beneficial effects in cardiovascular disease.

Hot Deformation Behavior and Processing Maps of a New Ti-6Al-2Nb-2Zr-0.4B Titanium Alloy.

The hot deformation behaviors of a new Ti-6Al-2Nb-2Zr-0.4B titanium alloy in the strain rate range 0.01-10.

Alkaline Hydrolysis Behavior of Metal-Organic Frameworks NH-MIL-53(Al) Employed for Sensitive Immunoassay via Releasing Fluorescent Molecules.

Nanosized metal-organic frameworks (MOFs) NH-MIL-53(Al) were synthesized from 2-aminoterephthalic acid (NH·HBDC) and AlCl by a facile hydrothermal method. The synthesized MOFs displayed good stability and a uniform particle size in a netural medium and were hydrolyzed in alkaline medium to release a large amount of fluorescent ligand NH·HBDC. Therefore, they can act as large-capability nanovehicles to load signal molecules for investigating various biorecognition events.

Dopamine-functionalized upconversion nanoparticles as fluorescent sensors for organophosphorus pesticide analysis.

Organophosphorus pesticide (OP) residues in agricultural products, herbal medicines and environment have attracted increasing concerns because they cause high healthy risk. Herein, a tyrosinase-mediated photoinduced electron transfer system was constructed for OPs analysis by using dopamine-functionalized upconversion nanoparticles (UCNPs) as fluorescent (FL) sensors. Dopamine quinone was produced by tyrosinase-mediated oxidation of dopamine on the surface of UCNPs, which acted as electron accepter to quench the FL emission of UCNPs.

High-efficiency encapsulation of Pt nanoparticles into the channel of carbon nanotubes as an enhanced electrocatalyst for methanol oxidation.

Pt-based nanostructures serving as anode catalysts for the methanol oxidation reaction (MOR) have been widely studied for many years. Nevertheless, challenging issues such as poor reaction kinetics and the short-term stability of the MOR are the main drawbacks of such catalysts and limit their applications. Herein, we have developed a facile approach to encapsulate Pt nanoparticles (NPs) inside the nanochannels of porous carbon nanotubes (CNTs; Pt-in-CNTs) as a new enhanced electrocatalytic material.