Airway exposure to lithium nickel manganese cobalt oxide particles induces alterations in lung microenvironment and potential kidney and liver damage in mice.

With the increasing use of lithium-ion batteries, the exposure and health effects of lithium nickel manganate cobalt (NMC), a popular cathode material for the battery, have attracted widespread attention. However, the main absorption routes and target organs of NMC are unknown. This study aims to systematically investigate the main absorption routes and target organs of NMC.

-Structural Changes in Early-stage Parkinson's Disease with Resting Tremor at Node, Edge and Network Level.

Background: Resting tremor in Parkinson's disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity, remains limited.

Methods: We investigated the structural change in PD patients with resting tremor (PD-WR) from a network perspective.

Quantitative proteomic landscape of the pathophysiology of adhesive arachnoiditis and its clinical significance: Structure and mechanism of TNC and RANBP1 proteins.

The pathophysiological mechanism of adhesive arachnoiditis (AA) is complex, involving the interaction of multiple proteins. In recent years, the development of quantitative proteomics technology has provided a new perspective to reveal its pathological mechanism. The main objective of this study was to reveal the changes of protein expression profiles in arachnoid tissue of patients with AA.

Diabetes may contribute to cognitive impairment in Parkinson's disease via damaging white matter tracts.

Parkinson's disease with dementia (PDD) severely affects the quality of life of patients with Parkinson's disease (PD) in the later stages. Recently, PD patients with diabetes were found to have a higher risk of cognitive decline and developing dementia with a faster progression, but the underlying mechanism remains unclear. Diabetes-related white matter damage may partially explain the mechanism by which diabetes participates in PDD.

-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer.

Introduction: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), and their polarization state significantly influences patient outcomes. This study investigates the inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing on its impact on TAM polarization and the induction of ferroptosis, a form of regulated cell death.

Methods: Utilizing both in vivo animal models and in vitro cellular assays, we assessed the impact of β-glucan on tumor growth, cellular proliferation, and migration.

Evaluating the health risk of probiotic supplements from the perspective of antimicrobial resistance.

Unlabelled: Antimicrobial resistance remains a public health threat. Probiotics harboring antimicrobial resistant genes (ARGs) have, in recent years, been considered a potential health risk. Studies conducted on probiotics from increasingly popular health supplements have raised the possibility of transmitting ARGs to commensals in the human gut, concomitantly establishing a reservoir of ARGs and risking acquisition by opportunistic pathogens.

Diagnostic value of 5 miRNAs combined detection for breast cancer.

Background: Breast cancer (BC) is the prevailing malignant tumor, with its prevalence and death rate steadily rising over time. BC often does not show obvious symptoms in its early stages and is difficult to distinguish from benign breast disease. We aimed to find a distinct group of miRNAs utilizing serum as a non-invasive biomarker for early BC diagnosis.

Direct cloning strategies for large genomic fragments: A review.

Mining large-scale functional regions of the genome helps to understand the essence of cellular life. The rapid accumulation of genomic information provides a wealth of material for genomic functional, evolutionary, and structural research. DNA cloning technology is an important tool for understanding, analyzing, and manipulating the genetic code of organisms.

Research Progress of in the Treatment of Gastrointestinal Cancer.

Gastrointestinal (GI) cancer stands as one of the most prevalent forms of cancer globally, presenting a substantial medical and economic burden on cancer treatment. Despite advancements in therapies, it continues to exhibit the second highest mortality rate, primarily attributed to drug resistance and post-treatment side effects. There is an urgent need for novel therapeutic approaches to tackle this persistent challenge.

Facet-Dependent Photocatalytic CO Reduction on TiO Crystals in the Presence of SO: Role of Surface Hydroxyl.

Photocatalytic CO reduction to solar energy makes great sense to mitigate the greenhouse effect caused by CO, and great efforts have been made to promote CO conversion efficiency. However, the effect of impurities in the photoreduction of CO has received relatively little attention. Here, the different CO photoreduction behaviors of TiO exposed (101) facet (TiO-101) and (001) facet (TiO-001) with an SO impurity were investigated.

Hydrogels in Alveolar Bone Regeneration.

Alveolar bone defects caused by oral trauma, alveolar fenestration, periodontal disease, and congenital malformations can severely affect oral function and facial aesthetics. Despite the successful clinical applications of bone grafts or bone substitutes, optimal alveolar bone regeneration continues to be challenging due to the complex oral environment and its unique physiological functions. Hydrogels that serve as promising candidates for tissue regeneration are under development to meet the specific needs for increased bone regeneration capacity and improved operational efficiency in alveolar bone repair.

Therapeutic Potential of Traditional Chinese Medicine Against Osteoarthritis: Targeting the Wnt Signaling Pathway.

Osteoarthritis (OA) is a chronic degenerative articular disease that leads to physical disability and reduced quality of life. The key pathological events in OA are cartilage degradation and synovial inflammation. Conventional therapies often lead to adverse effects that some patients are unwilling to endure.

Engineering Saccharomyces boulardii for Probiotic Supplementation of l-Ergothioneine.

Saccharomyces boulardii, as a probiotic yeast, has shown great potential in regulating gut health and treating gastrointestinal diseases. Due to its unique antimicrobial and immune-regulating functions, it has become a significant subject of research in the field of probiotics. In this study, we aim to enhance the antioxidant properties of S.

Sweet pepper extract reduces fat storage in by SREBP-SCD axis based on multiomics analysis.

Sweet pepper, a globally commercialized horticultural crop, has been demonstrated to impede fat accumulation, but its mechanism remains incompletely understood. This study was designed to explore the potential mechanism of sweet pepper in reducing fat accumulation in through RNA-seq and metabolome analysis. A total of 22 metabolites were identified from sweet pepper by UHPLC-ESI-TOF-MS analysis.

Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease.

Aim: To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease (CTD-ILD) and healthy controls (HCs) by optical coherence tomography angiography (OCTA) and to investigate the changes in microvascular density in abnormal eyes.

Methods: For a retrospective case-control study, a total of 16 patients (32 eyes) diagnosed with CTD-ILD were selected as the ILD group. The 16 healthy volunteers with 32 eyes, matched in terms of age and sex with the patients, were recruited as control group.

Colloidal Nanoparticles of a β-Cyclodextrin/L-Tryptophan Inclusion Complex for Use as Pickering Emulsion Stabilizers.

Inclusion complexes of β-cyclodextrin (β-CD) and tryptophan (Trp) were synthesized using an antisolvent approach, and fully characterized. Scanning electron microscope images proved the formation of the β-CD/Trp NPs and the powder X-ray diffraction pattern indicated the formation of a crystalline channel-like structure for the β-CD/Trp nanoparticles (NPs). The NPs of a β-CD/Trp inclusion complex were used as a natural stabilizer at the oil/water interface of a Pickering emulsion.

Structure-constraint induced increase in Lewis acidity of tris(-carboranyl)borane and selective complexation with Bestmann ylides.

The Lewis acidity of tris(-carboranyl)borane has been slightly increased by mimicking the structural evolution from triarylborane to 9-aryl-9-borafluorene. The -carborane-based analogue (CBH)B(CBH), obtained salt elimination between LiCBH and (CBH)BBr, has been fully characterized. Gutmann-Beckett and computational fluoride/hydride ion affinity (FIA/HIA) studies have confirmed the increase in Lewis acidity, which is attributable to structural constraint imposed by the CC-coupling between two carboranyl groups.

Ring-extended carbazole modification to activate efficient phosphorescent OLED performance of traditional host materials.

A novel "Ring-expansion" strategy is proposed to optimize traditional host molecular structures, featuring a rigid molecular skeleton and excellent transport of carriers. Consequently, the two novel host materials facilitate the fabrication of efficient phosphorescent OLEDs with suppressed efficiency roll-off compared to OLEDs based on the conventional host material (mCP).

On-chip multifunctional metasurfaces with full-parametric multiplexed Jones matrix.

On-chip metasurface for guided wave radiation works as an upgrade of conventional grating couplers, enriching the interconnection between guided wave and free-space optical field. However, the number of controllable parameters in equivalent Jones matrix of on-chip metasurface is limited that restricts the channels for multiplexing. Here, a supercell design based on detour phase and geometric phase has been proposed to reach full-parametric modulation of Jones matrix.

Implementing Optogenetic-Controlled Bacterial Systems in for Alleviation of Heavy Metal Poisoning.

(fruit fly) is an animal model chassis in biological and genetic research owing to its short life cycle, ease of cultivation, and acceptability to genetic modification. While the chassis offers valuable insights into drug efficacy, toxicity, and mechanisms, several obvious challenges such as dosage control and drug resistance still limit its utility in pharmacological studies. Our research combines optogenetic control with engineered gut bacteria to facilitate the precise delivery of therapeutic substances in for biomedical research.