The Gut Microbiota of the Greater Horseshoe Bat Confers Rapidly Corresponding Immune Cells in Mice.

Background: Emerging infectious diseases threaten human and animal health, with most pathogens originating from wildlife. Bats are natural hosts for many infectious agents. Previous studies have demonstrated that changes in some specific genes in bats may contribute to resistance to viral infections, but they have mostly overlooked the immune function of the bat gut microbiota.

An Impulsive Approach to State Estimation for Multirate Singularly Perturbed Complex Networks Under Bit Rate Constraints.

In this article, the problem of ultimately bounded state estimation is investigated for discrete-time multirate singularly perturbed complex networks under the bit rate constraints, where the sensor sampling period is allowed to differ from the updating period of the networks. The facilitation of communication between sensors and the remote estimator through wireless networks, which are subject to bit rate constraints, involves the use of a coding-decoding mechanism. For efficient estimation in the presence of periodic measurements, a specialized impulsive estimation method is developed, which aims to carry out impulsive corrections precisely at the instants when the measurement signal is received by the estimator.

CK2B Induces CD8 T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer.

Anti-PD-1 therapy has left an indelible mark in the field of non-small-cell lung cancer (NSCLC) treatment; however, its efficacy is limited in clinical practice owing to differences in the degree of effector T-cell exhaustion. Casein kinase 2 (CK2) is a protein kinase that plays an important role in T-cell immunity. In this study, it is aimed to explore the potential of targeting CK2 and its regulatory subunit CK2B to prevent or reverse T-cell exhaustion, thereby enhancing the efficacy of anti-PD-1 therapy in NSCLC.

Hydroxychavicol derivatives from Piper betle Linn. as natural PDE4 inhibitors with anti-inflammatory effects.

PDE4 inhibitors have been developed as anti-inflammatory medications primarily used in the clinical treatment of pulmonary inflammations such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. However, the application of these drugs is usually restricted by obvious side effects, such as nausea and vomiting. Our previous study found that several natural PDE4 inhibitors or their modified derivatives showed minimal side effects, particularly reduced incidence of nausea and vomiting, which aroused our interest in searching for natural PDE4 inhibitors.

ent-Atisane Diterpenoids with Anti-Influenza Virus Activity from Mangrove Plant Excoecaria agallocha L.

Three new ent-atisane diterpenoids, named agallolides N‒P (1-3) together with nine known diterpenoids (4-12) were isolated from the stems and twigs of the mangrove plant, Excoecaria agallocha L. . Various techniques, including high-resolution electrospray ionization mass spectrometry, spectroscopic methods, C-NMR calculations, DP4+ probability analysis, and equivalent circulating density calculations were applied to determine their molecular structures.

The role of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (nhhr) in prediabetes progression and the mediating effect of BMI: a longitudinal study in China.

Background: Diabetes prevalence in China is significant, with a large proportion in the prediabetes stage. Dyslipidemia is associated with abnormal glucose metabolism, and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) shows potential in diabetes risk assessment, but its role in prediabetes progression is understudied.

Methods: A longitudinal study from 2011 to 2015 using CHARLS data was conducted.

Discovery of structurally intriguing diterpenoids as anti-neuroinflammatory agents from mangrove plant Excoecaria agallocha L. via inhibiting macrophage polarization and inflammasome.

Emerging evidence indicates the inhibition of neuroinflammation is an important and promising strategy for managing Alzheimer's disease. Anti-neuroinflammatory agents are potential drug leads. In this work, seventeen diterpenoids (1-17) including ten previously undescribed ones, named excoaglolides A-J (1-10) were isolated from the stems and twigs of the mangrove plant, Excoecaria agallocha L.

Optimal cultivation concentration of duckweed for pollutant removal from biogas slurry.

Duckweed is an important plant for wastewater remediation and a promising alternative protein source for animal feed. This study aims to evaluate the biomass, protein accumulation, and wastewater purification capacity of duckweed under controlled cultivation conditions. Using pig farm biogas slurry as a nutrient source, this study analyzes the purification ability of duckweed at different slurry concentrations (2%, 4%, 6%, 8%, 10%) on chemical oxygen demand (COD), total nitrogen (TN), total phosphorus (TP), and ammonia nitrogen (NH-N) in biogas slurry.

Chloroplast-nuclear genome interaction drives asymmetric inverted repeats in chloroplast genome of Huperzia.

Huperzia plants are important natural medicine species that have attracted increased amounts of attention due to the presence of huperzine A (Hup A), which efficiently, selectively, and reversibly inhibits acetylcholinesterase activity. However, due to the complexity of the genome structure and lack of genetic information, the phylogenetic and evolutionary relationships of Huperzia species are still unclear. In this study, seven chloroplast genome structures of Huperzia were verified and comparatively analyzed, and the phylogenetic relationships between Huperzia and other related ferns were evaluated.

Global vegetation response to extreme climate from 2001 to 2020.

Exploring the spatiotemporal variations and response characteristics of global vegetation and extreme climate is of great significance for addressing global climate change and improving ecosystem stability. Based on ERA5 climate data from the European Centre for Medium-Range Weather Forecasts and MODIS normalized difference vegetation index (NDVI) data, we used Sen's trend analysis, correlation analysis, and random forest regression model to explore the responses of NDVI of five vegetation types (boreal and temperate forest, tropical forest, other woody vegetation, grassland, and cropland) to 23 extreme climate indices from 2001 to 2020. The results showed that global NDVI showed an overall increasing trend from 2001 to 2020.

Simultaneous Achievement of Enhanced Nonlinear Optical Absorption and Nonlinear Refraction in Highly Crystalline 2D Covalent Organic Frameworks Ultrathin Films.

Large enhancement of nonlinear absorption and nonlinear refraction are achieved simultaneously in highly ordered two dimensional (2D) covalent organic framework (COF) films prepared by solidliquid interface one-step method to overcome the weakness of COF powders in solubility. In the intrinsic nonlinear optical response obtained at 532 nm with 5 ns pulse, the nonlinear absorption coefficients (β) of two COF films are -4.87 × 10 and -1.

Unveiling the Role of in Cotton Salt Stress Tolerance: A Comprehensive Genomic and Functional Analysis of Genes.

Proline, a critical osmoregulatory compound, is integral to various plant stress responses. The gene, which encodes the rate-limiting enzyme in proline biosynthesis, known as ∆1-pyrroline-5-carboxylate synthetase, is fundamental to these stress response pathways. While the functions of genes in plants have been extensively documented, their specific roles in cotton remain inadequately characterized.

The path of corporate low-carbon behavioral change: The impact of digital transformation on corporate green sports brand loyalty.

Climate change poses significant challenges, making low-carbon development an essential global trend. In this context, building a green brand has become a critical strategy for companies to enhance consumer loyalty and maintain competitiveness. This study explores how the digital economy shapes sports brand loyalty, focusing on a dataset of Chinese A-share listed companies from Shanghai and Shenzhen, spanning 2011 to 2020.

Latent profile analysis of burnout, depression, and anxiety symptoms among Chinese medical staff with frontline anti-epidemic experience in the post-COVID-19 pandemic era.

Background: Frontline medical staff's psychological symptoms deserve persistent attention after 3 years of high-pressure and high-intensity work during the pandemic. In addition, the meaning of burnout and its relationship with depression and anxiety have long been debated. This study aimed to identify profiles of these symptoms among Chinese medical staff with frontline anti-epidemic experience, along with their distinguishing characteristics.

A Comprehensive Analysis In Silico of Genes in Maize Revealed Their Potential Role in Response to Abiotic Stress.

β-ketoacyl-CoA synthase (KCS) enzymes play a pivotal role in plants by catalyzing the first step of very long-chain fatty acid (VLCFA) biosynthesis. This process is crucial for plant development and stress responses. However, the understanding of genes in maize remains limited.

Inhibition, Gastritis Attenuation, and Gut Microbiota Protection in C57BL/6 Mice by NCUH062003.

(), one of the most prevalent pathogenic bacteria worldwide, is the leading cause of gastritis, gastric intestinal metaplasia, and gastric cancer. Antibiotics, the conventional treatment for eliminating , often lead to severe bacterial resistance, gut dysbiosis, and hepatic insufficiency and fail to address the inflammatory response or gastric mucosal damage caused by infection. In this study, based on 10-week animal experiments, two models of NCUH062003 for the prophylaxis and therapy of infection in C57BL/6 mice were established; a comprehensive comparative analysis was performed to investigate the anti- effect of probiotics, the reduction in inflammation, and repair of gastric mucosal damage.

Oral Immunization of Mice with a Nonantibiotic Recombinant Coexpressing TsNd and gp43 Protein Vaccine Combined with a Murine Interleukin-33 Adjuvant.

Trichinellosis, a zoonotic disease transmitted through food and caused by , is a significant health concern worldwide. Therefore, developing a safe and effective vaccine to combat infection is essential. In this study, a nonantibiotic strain lacking the gene served as a live bacterial vector to deliver antigens to the host, creating a novel oral vaccine.

Large-scale ecological infrastructures enhance the productivity of agro-socio-ecological systems by reducing soil erosion in the Loess Plateau.

Agro-socio-ecological systems are a crucial link connecting urbanization, agricultural development and environmental evolution. However, there is no effective research on realizing regional collaborative development and environmental governance of the agricultural social-system collaborative governance model, especially spatial differentiation governance. In this study, the region with the most severe soil erosion in the world was selected as the research area.

[Chemical constituents from petroleum ether fraction of Artemisia stolonifera].

The chemical constituents in the petroleum ether fraction of Artemisia stolonifera were investigated. Twenty compounds(1-20) were isolated from the petroleum ether fraction of A. stolonifera by silica gel, Sephadex LH-20, and ODS chromatography and semi-preparative HPLC.

Analysis of influencing factors on review efficiency of multidisciplinary scientific research projects using DEMATEL with a 5-point scale.

In the wake of advancing technology and the convergence of diverse disciplines, collaborative research across academic sectors has become instrumental in fostering innovation and tackling multifaceted challenges. The inherent complexity of such multidisciplinary endeavors, characterized by a myriad of research trajectories and a spectrum of expertise, poses significant challenges to effective review. This study aims to identify and analyze the factors influencing the review efficiency of multidisciplinary scientific research projects to ensure their smooth development and improved quality.

ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping.

ATR is the master safeguard of genomic integrity during DNA replication. Acute inhibition of ATR with ATR inhibitor (ATRi) triggers a surge in origin firing, leading to increased levels of single-stranded DNA (ssDNA) that rapidly deplete all available RPA. This leaves ssDNA unprotected and susceptible to breakage, a phenomenon known as replication catastrophe.

METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a.

Osteomyelitis (OM) is an inflammatory disease of bone infection and destruction characterized by dysregulation of bone homeostasis. Staphylococcus aureus (SA) has been reported to be the most common pathogen causing infectious OM. Recent studies have demonstrated that N6-methyladenosine (m6A) regulators are associated with the development of OM.