Machine learning-assisted label-free colorectal cancer diagnosis using plasmonic needle-endoscopy system.

Early and accurate detection of colorectal cancer (CRC) is critical for improving patient outcomes. Existing diagnostic techniques are often invasive and carry risks of complications. Herein, we introduce a plasmonic gold nanopolyhedron (AuNH)-coated needle-based surface-enhanced Raman scattering (SERS) sensor, integrated with endoscopy, for direct mucus sampling and label-free detection of CRC.

Child maltreatment and youth exposure to risky environments: Latent class analysis of youth activity spaces.

Background: Child maltreatment may alter the way that adolescents engage in and interact within the places they visit in their daily routines, namely youth activity spaces. Thus, it is important to understand how maltreatment experiences are linked to adolescents' exposure to environmental and contextual risks within their activity spaces.

Objective: The aim of the study was to explore the associations between child maltreatment and patterns of risk exposures within youth activity spaces among adolescents.

Coparenting Profiles and Children's Socioemotional Outcomes in Unmarried Parents with Low-Income.

Objective: This study aimed to examine patterns of mother-father coparenting relationship quality and their associations with child empathy, emotional insecurity, and behavior problems in families with low income.

Background: Given the growing number of nonmarital births and the high risk of relationship dissolution among cohabiting couples living with low income, it is important to examine the coparenting relationships among racially diverse unmarried couples from low-income contexts. To date, little research has assessed patterns of coparenting relationships and their associations with child socioemotional outcomes among this population.

Advancing COVID-19 Diagnosis: Enhancement in SERS-PCR with 30-nm Au Nanoparticle-Internalized Nanodimpled Substrates.

Real-time polymerase chain reaction (RT-PCR) with fluorescence detection is the gold standard for diagnosing coronavirus disease 2019 (COVID-19) However, the fluorescence detection in RT-PCR requires multiple amplification steps when the initial deoxyribonucleic acid (DNA) concentration is low. Therefore, this study has developed a highly sensitive surface-enhanced Raman scattering-based PCR (SERS-PCR) assay platform using the gold nanoparticle (AuNP)-internalized gold nanodimpled substrate (AuNDS) plasmonic platform. By comparing different sizes of AuNPs, it is observed that using 30 nm AuNPs improves the detection limit by approximately ten times compared to 70 nm AuNPs.

Bio-Inspired Organic Synaptor with In Situ Ion-Doped Ultrathin Polyelectrolyte Containing Acetylcholine-Like Cation.

An ion-based synaptic transistor (synaptor) is designed to emulate a biological synapse using controlled ion movements. However, developing a solid-state electrolyte that can facilitate ion movement while achieving large-scale integration remains challenging. Here, a bio-inspired organic synaptor (BioSyn) with an in situ ion-doped polyelectrolyte (i-IDOPE) is demonstrated.

Association between longitudinal patterns of child maltreatment experiences and adolescent substance use.

Background: Although there is a well-established link between child maltreatment and adolescent substance use, it remains unclear if and how longitudinal patterns of maltreatment experiences are associated with substance use in adolescence.

Objective: The purpose of the study was to examine how distinct patterns of longitudinal maltreatment experiences are associated with adolescent substance use.

Participants And Setting: The participants were 899 adolescents from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN).

Coparenting, parental anxiety/depression, and child behavior problems: The actor-partner interdependence model with low-income married couples.

A considerable amount of research has suggested significant associations among perceived coparenting relationships, parental anxiety/depression, and children's adjustment. Although family members' function is influenced by other members in a shared context, much of the prior work relied on one parent's perspective to examine the relationship between both parents. To address this important limitation, we applied the actor-partner interdependence model and accounted for the interdependence between fathers and mothers in examining the mediating role of parental anxiety/depression in the association between coparenting quality and child behavior problems.

A comparison of the methods for detecting dyadic patterns in the actor-partner interdependence model.

In the actor-partner interdependence model (APIM), various dyadic patterns between an actor and partner can be examined. One widely used approach is the parameter k method, which tests whether the ratio of the partner effect to the actor effect (p/a) is significantly different from pattern values such as -1 (contrast), 0 (actor-only or partner-only), and 1 (couple). Although using a phantom variable was a useful method for estimating the k ratio, it is no longer necessary due to the availability of statistical packages that allow for a direct estimation of the k ratio without the inclusion of the phantom variable.

Polyimide Surface Dielectric Barrier Discharge for Inactivation of SARS-CoV-2 Trapped in a Polypropylene Melt-Blown Filter.

Surface dielectric barrier discharge (SDBD) was used to inactivate the infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) trapped in a polypropylene (PP) melt-blown filter. We used a dielectric barrier made of polyimide films with hexagonal holes through which air flowed. In a cylindrical wind tunnel, the SDBD device supplied reactive oxygen species such as ozone to the SARS-CoV-2 trapped in the PP filter.

Can resilience change over time? Patterns and transitions in resilience among young children involved with the child welfare system.

This study examined transitions in resilience profiles and the role of caregiver risk and protective factors in resilience transition probabilities over 18 months among children involved with the child welfare system, using latent profile analysis and latent transition analysis. The sample included 486 children (48% female, baseline M  = 3.49).

Label-free detection and discrimination of respiratory pathogens based on electrochemical synthesis of biomaterials-mediated plasmonic composites and machine learning analysis.

Seasonal outbreaks of respiratory viral infections remain a global concern, with increasing morbidity and mortality rates recorded annually. Timely and false responses contribute to the widespread of respiratory pathogenic diseases owing to similar symptoms at an early stage and subclinical infection. The prevention of emerging novel viruses and variants is also a big challenge.

Patterns of coparenting and young children's social-emotional adjustment in low-income families.

This study identified coparenting patterns using data collected across 2007-2010 from low-income couples (N = 2915; 26.90% non-Hispanic White; 9.41% non-Hispanic Black; 34.

Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection.

Rapid, sensitive, simultaneous quantification of multiple biomarkers in point-of-care (POC) settings could improve the diagnosis and management of sepsis, a common, potentially life-threatening condition. Compared to high-end commercial analytical systems, POC systems are often limited by low sensitivity, limited multiplexing capability, or low throughput. Here, we report an ultrasensitive, multiplexed plasmonic sensing technology integrating chemifluorescence signal enhancement with plasmon-enhanced fluorescence detection.

In-situ fabrication of 3D interior hotspots templated with a protein@Au core-shell structure for label-free and on-site SERS detection of viral diseases.

Nanoscale plasmonic hotspots play a critical role in the enhancement of molecular Raman signals, enabling the sensitive and reliable trace analysis of biomedical molecules via surface-enhanced Raman spectroscopy (SERS). However, effective and label-free SERS diagnoses in practical fields remain challenging because of clinical samples' random adsorption and size mismatch with the nanoscale hotspots. Herein, we suggest a novel SERS strategy for interior hotspots templated with protein@Au core-shell nanostructures prepared via electrochemical one-pot Au deposition.

Organometallic hotspot engineering for ultrasensitive EC-SERS detection of pathogenic bacteria-derived DNAs.

The sensitivity and limit-of-detection (LOD) of the traditional surface-enhanced Raman spectroscopy (SERS) platform suffer from the requirement of precise positioning of small analytes, including DNAs and bacteria, into narrow hotspots. In this study, a novel SERS sensor was developed using electrochemical deposition onto metal nanopillars (ECOMPs) combined with complementary DNAs (cDNAs) for the detection of pathogenic bacteria. Applying a redox potential to AuCl ions actively engineered the organometallic hotspots based on the cDNAs in a short time (<10 min) and simultaneously produced SERS signals.

Hydrogel-Assisted 3D Volumetric Hotspot for Sensitive Detection by Surface-Enhanced Raman Spectroscopy.

Effective hotspot engineering with facile and cost-effective fabrication procedures is critical for the practical application of surface-enhanced Raman spectroscopy (SERS). We propose a SERS substrate composed of a metal film over polyimide nanopillars (MFPNs) with three-dimensional (3D) volumetric hotspots for this purpose. The 3D MFPNs were fabricated through a two-step process of maskless plasma etching and hydrogel encapsulation.

Patterns of Father Involvement and Child Development among Families with Low Income.

This study examined patterns of father involvement and their relations with social, behavioral, and cognitive development among low-income children < 5 years. Latent class analysis on data from 2650 fathers (Mage = 29.35 years) in the Supporting Healthy Marriages program revealed four father involvement patterns: (1) High positive involvement (48%); (2) engaged but harsh discipline (42%); (3) low cognitive stimulation (8%); and (4) lower involvement (2%).

Assessing Differential Effects of Somatic Amplification to Positive Affect in Midlife and Late Adulthood-A Regression Mixture Approach.

This study aims to provide an empirical demonstration of a novel method, regression mixture model, by examining differential effects of somatic amplification to positive affect and identifying the predictors that contribute to the differential effects. Data derived from the second wave of Midlife in the United States. The analytic sample consisted of 1,766 adults aged from 33 to 84 years.

Preliminary Validation of a Continuum Model for Dimple Patterns on Polyethylene Naphthalate via Ar Ion Beam Sputtering.

This work reports the self-organization of dimple nanostructures on a polyethylene naphthalate (PEN) surface where an Ar ion beam was irradiated at an ion energy of 600 eV. The peak-to-peak roughness and diameter of dimple nanostructures were 29.1~53.

A Comparison of Different Nonnormal Distributions in Growth Mixture Models.

The purpose of the present study is to compare nonnormal distributions (i.e., , skew-normal, skew- with equal skew and skew- with unequal skew) in growth mixture models (GMMs) based on diverse conditions of a number of time points, sample sizes, and skewness for intercepts.