Publications by authors named "Junye Zhu"
Mitochondrial diseases: from molecular mechanisms to therapeutic advances.
Signal Transduct Target Ther
January 2025
Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochondrial genetic disorders can arise from a wide range of mutations in either mitochondrial or nuclear DNA, which encode mitochondrial proteins or other contents.
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- The study explores how lncRNA-MM2P affects retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR).
- Researchers used various methods like RT-qPCR and western blotting to analyze gene expression, and assessed changes in retinal structure using immunofluorescence staining.
- Findings indicate that lncRNA-MM2P promotes M2 macrophage polarization, which in turn regulates neovascularization, suggesting it could be a target for therapies related to retinal diseases.
Oral matrine alleviates CCl4-induced liver fibrosis via preserved HSP72 from modulated gut microbiota.
Biomed Pharmacother
September 2024
Article Synopsis
- Hepatic fibrosis is linked to imbalances in gut microbiota and host metabolism, and this study investigates the impact of matrine on these factors.
- Matrine effectively reduces liver fibrosis in mice, enhancing levels of heat shock protein 72 (HSP72), and this effect is compromised when HSP72 is inhibited.
- The study identifies a "gut microbiota-hepatic HSP72" axis as a crucial mechanism by which matrine alleviates liver fibrosis, suggesting it could be a target for new therapeutic approaches.