Feasibility and Effectivity of an Amine-Grafted Alumina Adsorbent for Direct Air Capture.

Direct air capture (DAC) has been identified as a necessary negative emission technology (NET) to solve global warming. DAC methods have been divided into two major types: solvent absorption and sorbent adsorption. Aqueous amine absorption is the major method in postcombustion carbon capture, not in DAC because contactors blow large volumes of air over the solvent, which results in high evaporation of solvents.

Recent advances in direct air capture by adsorption.

Significant progress has been made in direct air capture (DAC) in recent years. Evidence suggests that the large-scale deployment of DAC by adsorption would be technically feasible for gigatons of CO capture annually. However, great efforts in adsorption-based DAC technologies are still required.

1.3 kV Vertical GaN-Based Trench MOSFETs on 4-Inch Free Standing GaN Wafer.

In this work, a vertical gallium nitride (GaN)-based trench MOSFET on 4-inch free-standing GaN substrate is presented with threshold voltage of 3.15 V, specific on-resistance of 1.93 mΩ·cm, breakdown voltage of 1306 V, and figure of merit of 0.

Target-Activated, Light-Actuated Three-Dimensional DNA Walker Nanomachine for Amplified miRNA Detection.

Accurate analysis of microRNA (miRNA) is promising for elucidation of cancer processes and therapeutic effects. In this study, we reported a new target-activated, light-actuated three-dimensional (3D) DNA walker on gold nanoparticles for sensitive detection of miRNA using pyrene-incorporated DNAzyme analogues. In this design, the target miRNA activated the 3D DNA walker system to releases the walking arm.

Target-driven assembly of DNAzyme probes for simultaneous electrochemical detection of multiplex microRNAs.

In this work, we employed target-driven assembly of a Mg-dependent DNAzyme to develop an ultrasensitive electrochemical biosensor for the simultaneous detection of miRNA-21 and miRNA-141. The target miRNAs could hybridize with two partial DNAzymes, facilitating the formation of a stable and active Mg-dependent DNAzyme. With the help of the Mg cofactor, the DNAzyme could circularly cleave the ferrocene (Fc) or methylene blue (MB) labelled hairpin probes and release Fc and MB labels from the electrode surface, which could significantly amplify the current suppression to achieve multiple detection of small amounts of miRNA-21 and miRNA-141.

Reducing PD-L1 expression with a self-assembled nanodrug: an alternative to PD-L1 antibody for enhanced chemo-immunotherapy.

The binding between the immune checkpoints, programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1), compromises T-cell-mediated immune surveillance. Immune checkpoint therapy using immune checkpoint inhibitors (ICIs) to block PD-L1 on cancer cell membrane or PD-1 on activated T cell membrane can restore antitumor function of T cell. However, the intracellular expression of PD-L1 and its active redistribution to cancer cell membrane may impair the therapeutic benefits of ICIs.

Evaluation of heavy metal element detection in municipal solid waste incineration fly ash based on LIBS sensor.

Heavy metal elements are the main pollutants in municipal solid waste incineration (MSWI) fly ash, the online detection of heavy metals in MSWI fly ash could benefit its subsequent solidification treatment and land-filling. In this paper, laser induced breakdown spectroscopy (LIBS) was introduced to the rapid measurement of heavy metal elements in MSWI fly ash. Considering the serious matrix effect in MSWI fly ash, the multiple linear regression model combined with internal standard method was used to establish the calibration curves of heavy metals.