Publications by authors named "Junyao Li"

Introduction: The controversy of antidepressant use in bipolar depression remains controversial. Agomelatine (AGO) is an effective antidepressant in major depressive disorder (MDD), but its application in bipolar depression was little discussed. We aimed to provide a comprehensive systematic review of clinical evidence from studies examining the efficacy and safety of AGO for bipolar depression.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers developed a versatile chiral recognition platform using popcorn-like gold nanoparticles (AuNPs) and bovine serum albumin (BSA) to discriminate between tyrosine (Tyr) enantiomers.
  • The platform takes advantage of the inherent chirality of BSA, which alters the chiral recognition ability of the AuNPs when combined.
  • Additionally, the photothermal effect of the AuNPs, activated by near-infrared (NIR) light, can reversibly restore the original chiral recognition ability of the AuNPs, enabling precise and on-demand regulation for potential applications in detection and therapy.
View Article and Find Full Text PDF

Purpose: The purpose of this study was to evaluate the ability of global inhomogeneity index (GI) and left-right asymmetry index (AI) based on electrical impedance tomography (EIT) to be used in assessing cerebral perfusion heterogeneity. The diagnostic value of these two indices in identifying abnormalities in the degree of cerebral perfusion heterogeneity was also explored.

Methods: In this study, Transcranial Doppler (TCD) was used as a control, and unilateral carotid artery was compressed to change the degree of heterogeneity of cerebral perfusion in 15 healthy volunteers.

View Article and Find Full Text PDF

Accurate human cerebrospinal fluid (CSF) dielectric parameters are critical for biological electromagnetic applications such as the electromagnetic field modelling of the human brain, the localization and intensity assessment of electrical generators in the brain, and electromagnetic protection. To detect brain damage signals during temperature changes by electrical impedance tomography (EIT), the change in CSF dielectric parameters with frequency (10 Hz-100 MHz) and temperature (17-39 °C) was investigated. A Debye model was first established to capture the complex impedance frequency and temperature characteristics.

View Article and Find Full Text PDF

Poly I:C (pIC) can act on endosomal and cytosolic pathogen recognition receptors to enhance T cell immunity. However, the poor cytosolic delivery of pIC and lack of facile methods for codelivery with antigens limit its efficacy. Inspired by the structure of a virus, we developed a ipoanoel (LNG) consisting of a nanogel core and lipid shell to address these challenges.

View Article and Find Full Text PDF

Porous chiral materials accompanied by electrochemiluminescence (ECL) activity are rarely reported for enantioselective discrimination because of the big challenges to integrate the stereogenic center and ECL-active unit in the backbone. In the present study, ionic chiral covalent organic frameworks (iCCOFs) consisting of the pyridinium unit as the ECL-active species were prepared by a facile strategy. We were amazed that such iCCOFs could display strong cathodic ECL responses.

View Article and Find Full Text PDF

Reading digital information from highly dense but lightweight DNA medium nowadays relies on time-consuming next-generation sequencing. Nanopore sequencing holds the promise to overcome the efficiency problem, but high indel error rates lead to the requirement of large amount of high quality data for accurate readout. Here we introduce Composite Hedges Nanopores, capable of handling indel rates up to 15.

View Article and Find Full Text PDF

Hollow polymer microspheres (HPMs) were synthesized, which were then hydrolyzed in aqueous ammonia to produce carboxyl (-COOH) groups on their surface. L-phenylalanine (L-Phe) was grafted to the hydrolyzed HPMs (H-HPMs) through amidation reactions, endowing the H-HPMs with chirality. The resultant chiral HPMs (C-HPMs) were used for the chiral discrimination of tryptophan (Trp) isomers.

View Article and Find Full Text PDF

Activating the STING pathway in the cytosol of tumor-infiltrating antigen-presenting cells (APCs) represents a promising strategy to elicit potent antitumor immune responses for cancer therapy. However, STING agonists are mostly small hydrophilic molecules that suffer from rapid clearance and poor cytosolic delivery following systemic administration. While various nanoparticles have been developed to promote cytosolic delivery, they often exhibit premature drug release during circulation.

View Article and Find Full Text PDF
Article Synopsis
  • The study introduces a new liponanogel (LNG) platform designed to improve the delivery and effectiveness of the immunostimulatory compound polyinosinic:polycytidylic acid (pIC) for cancer therapy.
  • The LNG consists of a lipid shell around a nanogel made from hyaluronic acid, manganese, and pIC, which enhances the cytosolic delivery of pIC while activating immune pathways.
  • When injected, this innovative platform not only disrupts tumor blood vessels and induces tumor cell death but also boosts overall immune response, showing promise for effective cancer treatment.
View Article and Find Full Text PDF
Article Synopsis
  • This study introduces a novel achiral ionic covalent organic framework (COF) that exhibits electrochemiluminescence (ECL) properties, synthesized through the Zincke reaction.
  • The COF successfully detects chiral Co(III) complexes, showing significant differences in ECL responses between different amino alcohol enantiomers.
  • A strong linear relationship is established between enantiomeric composition and ECL intensity, offering a reliable method for analyzing enantiomeric purity in samples.
View Article and Find Full Text PDF

Photocatalytic water splitting for hydrogen production offers a feasible solution to the problems of energy shortages and environmental pollution. However, its low photocatalytic efficiency limits the application of this technology in real world scenarios. In this study, a two-dimensional AlN/PSi-GaS-I van der Waals heterojunction is constructed and the properties of water photolysis are studied based on first-principles calculations.

View Article and Find Full Text PDF

Nowadays, covalent-organic frameworks (COFs) integrated with the electrochemiluminescence (ECL) behavior are highly desired owing to the significant advantages including multifunctionality, high sensitivity, and low background noise. Here, two ionic COFs (iCOFs) consisting of the anthryl-extended viologen as the backbone were designed and synthesized via the Zincke reaction. It is found for the first time that the as-prepared iCOFs accompanied by potassium persulfate as the coreactant can provide a clear ECL response in a water-bearing medium.

View Article and Find Full Text PDF

Inducing high levels of antigen-specific CD8α T cells in the tumor is beneficial for cancer immunotherapy, but achieving this in a safe and effective manner remains challenging. Here, we have developed a designer liposomal nanovaccine containing a sonosensitizer (LNVS) to efficiently program T cell immunity in mice. Following intravenous injection, LNVS accumulates in the spleen in a protein corona and fluidity-dependent manner, leading to greater frequencies of antigen-specific CD8α T cells than soluble vaccines (the mixture of antigens and adjuvants).

View Article and Find Full Text PDF
Article Synopsis
  • Juvenile idiopathic arthritis (JIA) is a common chronic inflammatory disease in kids, and adalimumab is a key treatment, but its effects on those with psychiatric disorders are not well-studied.
  • The case of a 12-year-old boy highlights that his emotional instability may be linked to adalimumab use, as he stabilized after stopping the medication.
  • While these drugs can be beneficial for inflammatory issues, they might trigger mood swings in adolescents, suggesting the need for careful monitoring and more research on their effects, especially for those with mood disorders.
View Article and Find Full Text PDF

Based on the modified cross-linking of the degradable natural polymers chitosan oligosaccharides (COS) and gelatin (GEL) via introduction of a functional bridge 3,3'-dithiodipropionic acid, this study constructed an environmentally responsive dinotefuran (DNF) delivery system (DNF@COS-SS-GEL). The introduction of the disulfide bond (-S-S-) endowed DNF@COS-SS-GEL with redox-responsive properties, allowing for the rapid release of pesticides when stimulated by glutathione (GSH) in the simulated insect. Compared with commercial DNF suspension concentrate (DNF-SC), DNF@COS-SS-GEL showed superior wet spreading and retention performance on cabbage leaves with a reduced contact angle (57°) at 180 s and 4-fold increased retention capacity after rainfall washout.

View Article and Find Full Text PDF
Article Synopsis
  • - Understanding how electrical properties change with temperature in liver tissue is important for effective thermal therapy, which can improve treatment accuracy.
  • - The study used a mouse model to analyze the electrical properties of healthy livers and liver tumors by heating them with a laser and measuring their impedance across a temperature range of 30 °C to 90 °C.
  • - Results showed a clear relationship between temperature and impedance, with significant differences between healthy livers and tumors, suggesting that these findings could enhance radiofrequency ablation technologies and temperature monitoring techniques for liver treatments.
View Article and Find Full Text PDF

Weaning is a critical stage in the growth and development of piglets, often inducing stress reactions. This study aims to investigate the effects of (PBd) derived from Ningxiang pigs on growth performance, intestinal apoptosis, oxidative damage, and inflammation in ETEC-challenged weaned piglets. A total of 22 Duroc × Landrace × Yorkshire (DLY) piglets, 24 days old with similar body weights, were randomly divided into three groups: Control ( = 7), ETEC ( = 7), and PBd + ETEC ( = 8).

View Article and Find Full Text PDF

Acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) represents a primary cause of treatment failure in non-small cell lung cancer (NSCLC) patients. Chemokine (C-C motif) ligand 2 (CCL2) is recently found to play a pivotal role in determining anti-cancer treatment response. However, the role and mechanism of CCL2 in the development of EGFR-TKIs resistance have not been fully elucidated.

View Article and Find Full Text PDF

Failure of articular cartilage lubrication and inflammation are the main causes of osteoarthritis (OA), and integrated treatment realizing joint lubrication and anti-inflammation is becoming the most effective treat model. Inspired by low friction of human synovial fluid and adhesive chemical effect of mussels, our work reports a biomimetic lubricating system that realizes long-time lubrication, photothermal responsiveness and anti-inflammation property. To build the system, a dopamine-mediated strategy is developed to controllably graft hyaluronic acid on the surface of metal organic framework.

View Article and Find Full Text PDF
Article Synopsis
  • Diet is really important for mental health, especially in conditions like depression and Bipolar Disorder (BD), but not much research has focused on how food affects BD.
  • Scientists used a method called Mendelian Randomization to study 28 different eating habits and how they relate to BD using data from a big UK study.
  • They found that eating non-oily fish and sponge pudding might increase the risk of BD, and others like oily fish and cooked vegetables could also be risky, so they suggest being careful about what you eat when trying to manage BD.
View Article and Find Full Text PDF

Chiral analysis with simple devices is of great importance for analytical chemistry. Based on the photothermal (PT) effect, a simple chiral sensor with a portable laser device as the light source and a thermometer as the detection tool was developed for the chiral recognition of tryptophan (Trp) isomers and the sensitive sensing of one isomer (L-Trp). Gold nanorods (GNRs), which have outstanding photo-thermal conversion ability due to their localized surface plasma resonance (LSPR) effect, are used as PT reagents, and biomacromolecules bovine serum albumin (BSA) are used as natural chiral sources, and thus, GNRs@BSA was obtained through Au-S bonds.

View Article and Find Full Text PDF

For the first time, a novel donor-acceptor structured COF with excellent photothermal conversion and mono-dispersity in various oils without any further modification is reported; it realized responsive friction reduction, excellent antiwear and long-time lubrication.

View Article and Find Full Text PDF

Pulmonary delivery of immunostimulatory agents such as poly(I:C) to activate double-stranded RNA sensors MDA5 and RIG-I within lung-resident antigen-presenting cells is a potential strategy to enhance antitumor immunity by promoting type I interferon secretion. Nevertheless, following pulmonary delivery, poly(I:C) suffers from rapid degradation and poor endosomal escape, thus limiting its potency. Inspired by the structure of a virus that utilizes internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, we developed a liponanogel (LNG)-based platform to overcome the delivery challenges of poly(I:C).

View Article and Find Full Text PDF

A molecularly imprinted electrochemical sensor was facilely fabricated for the detection of thymol (THY). o-Phenylenediamine (oPD) was used as the functional monomer and electropolymerized on the surface of the glassy carbon electrode (GCE) by using THY as the templates. After the THY templates were removed with 50 % (v/v) ethanol, imprinted cavities complementary to the templates were formed within the poly(o-phenylenediamine) (PoPD) films.

View Article and Find Full Text PDF