Publications by authors named "Junyang Fang"
Fowl adenovirus serotype 4 (FAdV-4) infections result in substantial economic losses in the poultry industry. Recent findings have revealed that FAdV-4 significantly suppresses the host immune response upon infection; however, the specific viral and host factors contributing to this immunomodulatory activity remain poorly characterized. Moreover, diverse cell types exhibit differential immune responses to FAdV-4 infection.
View Article and Find Full Text PDFArticle Synopsis
- * The study investigates how H9N2 enhances the infection of avian pathogenic Escherichia coli (APEC) in chicken oviduct epithelial cells, identifying that H9N2 increases APEC adhesion by upregulating fibronectin expression.
- * The findings reveal that the NS1 protein of the H9N2 virus activates the TGF-β signaling pathway, which regulates fibronectin and promotes APEC infections, providing insights into the combined effects of viral and bacterial infections in poultry. *
() is one of the major poultry pathogens causing infectious synovitis, airsacculitis, a high incidence of shell breakage, and egg production loss. However, the pathogenesis of remains unclear. Adhesion of mycoplasmas to host cells is a crucial step in infection and colonization.
View Article and Find Full Text PDFArticle Synopsis
- A primary avian pathogen is responsible for causing serious respiratory issues in birds, making vaccination the recommended method for controlling infection.
- The study identified key immunogenic proteins (DnaK, enolase, EF-Tu, MSPB, LP78, and NADH oxidase) as potential targets for new subunit vaccines, which were shown to induce strong immune responses in chickens.
- Results indicated that certain vaccines, particularly rEnolase, provided significant protection against the pathogen, although they did not fully prevent infection, highlighting the need for further vaccine development.
Porcine reproductive and respiratory syndrome (PRRS), a significant viral infectious disease that commonly occurs among farmed pigs, leads to considerable economic losses to the swine industry worldwide. Major vault protein (MVP) is a host factor that induces type Ⅰ interferon (IFN) production. In this study, we evaluated the effect of MVP on PRRSV infection in CRL2843 cell lines and porcine alveolar macrophages (PAMs).
View Article and Find Full Text PDFBackground: Enzyme-linked immunosorbent assay (ELISA) is a common method for diagnosing swine influenza. However, the production of classical antibodies is both costly and time-consuming. As a promising alternative diagnostic tool, single-domain antibodies (sdAbs) offer the advantages of simpler and faster generation, good stability and solubility, and high affinity and specificity.
View Article and Find Full Text PDF