Publications by authors named "Junyan Lin"

Introduction: Albuminuria is a crucial marker of kidney damage and serves as an early indicator of the risk for chronic kidney disease (CKD). Recent studies have suggested that the cardiometabolic index (CMI), could be valuable for screening renal insufficiency. However, the relationship between CMI and albuminuria remains underexplored.

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This study investigated pathogenic genes associated with non-syndromic cleft lip with or without cleft palate (NSCL/P) through transcriptome-wide association studies (TWAS). By integrating expression quantitative trait loci (eQTL) data with genome-wide association study (GWAS) data, we identified key susceptibility genes, including . Notably, the variant rs12884809 G>A was associated with an increased risk of NSCL/P by enhancing the binding of the transcription factor ELK1 to the promoter, thereby activating its expression.

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The NC_000006.12: g.34887814C>G variant in TAF11 was identified as a potential functional variant in a Chinese pedigree including two non-syndromic cleft lip only (NSCLO) cases.

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Background: Renal fibrosis, a hallmark of chronic kidney disease, is closely associated with dysregulated gluconeogenesis. Tanshinone I (Tan I), a bioactive compound derived from the traditional Chinese medicine Danshen, exhibits antifibrotic and anti-inflammatory properties. However, its effects on gluconeogenesis and the mechanisms through which it alleviates renal fibrosis remain unclear.

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Enocyanin (ENO), an anthocyanin extracted from grapes, has been shown to exert inhibitory effects on acid phosphatase and inflammation; however, its role in osteogenesis and bone formation is currently unknown. The present study aimed to investigate the effects of ENO on osteogenesis and bone formation , and to explore the rudimentary mechanisms. KusaO cells were employed to evaluate the osteogenic role of ENO by Alizarin red S staining, ALP staining, quantitative PCR and western blotting, and an analysis of the therapeutic effects of ENO on a femoral fracture model was performed using stereo microscope, micro‑CT and histological staining.

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Article Synopsis
  • Loquat leaf extract (LLE) was added to guar gum and pullulan to create an eco-friendly packaging film for preserving Chinese water chestnuts (CWCs).
  • The best results were achieved with 4% LLE, which showed improved water vapor permeability, mechanical strength, and antioxidant properties compared to other films.
  • After 4 days of storage, the GPE film maintained CWCs' quality better than traditional plastic wrap, indicating its potential as a sustainable packaging alternative.
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Nucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures, suggesting potential non-transport-related roles. This review consolidates findings on cytoplasmic nucleoporin assemblies across different states, including normal physiological conditions, stress, and pathology, exploring their structural organization, formation dynamics, and functional implications.

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Pullulan-based composite film can be a potential alternative packing material to non-environmentally friendly plastic wrap (PE) to preserve fresh-cut carrots. However, many developed pullulan-based composites either have high water vapor permeability (WVP) and high mechanical strength or vice versa, which limits the practicality of the developed packaging materials for potential commercialization. Herein, Abelmoschus manihot gum (AMG)/pullulan/magnesium L-ascorbate (MLA) was created as a green composite film (APL) to preserve fresh-cut carrots.

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Assembly of macromolecular complexes at correct cellular sites is crucial for cell function. Nuclear pore complexes (NPCs) are large cylindrical assemblies with eightfold rotational symmetry, built through hierarchical binding of nucleoporins (Nups) forming distinct subcomplexes. Here, we uncover a role of ubiquitin-associated protein 2-like (UBAP2L) in the assembly and stability of properly organized and functional NPCs at the intact nuclear envelope (NE) in human cells.

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Zintl compounds have continuously received significant attention, primarily due to their structural characteristics that align with the properties of the electron crystal and phonon glass. In this study, the crystal structure and thermoelectric properties of the quaternary Zintl chalcogenide BaScCuTe are investigated. The band structure calculations for BaScCuTe reveal a slight energy split of 0.

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Objectives: Three distinct models were utilized to investigate the combined impacts of serum aldehyde exposure and periodontitis.

Materials And Methods: We performed a cross-sectional analysis using data from 525 participants in the 2013-2014 National Health and Nutrition Examination Survey (NHANES). The directed acyclic graphs (DAG) were used to select a minimal sufficient adjustment set of variables (MSAs).

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Calcaneal tuberosity avulsion fracture, an extra-articular injury, is a rare fracture caused internally by Achilles tendon driven following intense contraction of gastrocnemius-soleus complex, and externally by low-energy (possibly high-energy). Moreover, the risk of injuries of the skin and Achilles tendon around calcaneal tuberosity is closely related to Lee classification and Carnero-Martín de Soto Classification of calcaneal tuberosity avulsion fracture. Although the diagnosis confirmed by X-ray, digital imaging and computed tomography (CT), magnetic resonance imaging (MRI) should also be used to evaluate soft tissue.

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In patients with metastatic colorectal cancer (mCRC) exhibiting no evidence of disease (NED), this study assessed the efficacy and safety of capecitabine maintenance therapy. The single-arm, phase II CAMCO trial enrolled mCRC-NED patients after first-line treatment, administering oral capecitabine maintenance for 1 year. A total of 93 patients were enrolled.

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Article Synopsis
  • Salvianolic acid C (SAC) is a natural compound that may protect against kidney diseases, specifically by targeting tubulointerstitial fibrosis in the kidneys.* -
  • Experiments using mouse models and human kidney cells showed that SAC treatment reduced fibrosis levels and inhibited related protein expressions, suggesting a protective role against kidney damage.* -
  • The study concluded that SAC works by inhibiting epithelial-mesenchymal transition (EMT) and operates through the TGF-β/Smad signaling pathway to alleviate kidney fibrosis.*
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  • - The study aimed to investigate the relationship between sleep duration and the risk of developing type II diabetes in adults by analyzing multiple databases and literature up to October 2022.
  • - A meta-analysis of 5 studies involving 74,226 subjects found that women with long sleep duration (LSD) have a significantly higher risk of type II diabetes compared to men, while men with short sleep duration (SSD) show a trend towards higher risk that isn't statistically significant.
  • - The findings suggest that women with LSD are at greater risk for type II diabetes, and that men in Europe and America with SSD are also at an increased risk compared to men from other regions.
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Aim: Mammalian STE20-like protein kinase 2 (MST2) plays an important role in apoptosis and the development of many disorders. Here, we aim to explore if genetic variants in MST2 are associated with the risk of non-syndromic cleft lip with or without palate (NSCL/P).

Materials And Methods: The association study was performed in a two-stage study of 1,069 cases and 1,724 controls to evaluate the association between genetic variants in the MST2 and NSCL/P risk.

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  • * In winemaking, existing studies mainly focus on specific aspects of wine affected by ultrasound rather than providing a comprehensive analysis of its effects throughout the winemaking process.
  • * This review compiles research on the use of ultrasound in winemaking stages—extraction, fermentation, aging, and sterilization—highlighting its advantages, disadvantages, and potential future developments.
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  • Cranial neural crest cells (CNCCs) are essential for forming many craniofacial structures, making them a key focus for studying craniofacial diseases.
  • A literature review of 293 articles identified 17 relevant studies that address methods for isolating and culturing CNCCs from wild-type mice.
  • The review highlights the challenges in purifying stem cells while promoting their growth without premature differentiation, stressing the need for standardized protocols in CNCC research.
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  • Hemolytic disease in grass carp causes hemolysis, releasing hemoglobin (Hb) and reactive oxygen species (ROS), which lead to oxidative damage in tissues.
  • The study found that this hemolysis resulted in increased ROS production, apoptosis, and inflammation-related gene expression in the head and middle kidneys of the grass carp.
  • Different forms of hemoglobin were shown to further activate the NF-κB signaling pathway, amplifying the inflammatory response and cell damage, confirmed through additional testing methods like flow cytometry.
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  • This study examines how obstructive sleep apnea-hypopnea syndrome (OSAHS) is linked to osteoporosis, focusing on its effects on the incidence of the disease and bone mineral density (BMD) in the lumbar spine.
  • A systematic search of multiple databases identified 15 articles involving over 113,000 subjects, revealing that people with OSAHS have a significantly higher incidence of osteoporosis and lower lumbar spine BMD and T-scores compared to a control group.
  • The study concludes that increased awareness and management of OSAHS is essential to lower the risk of osteoporosis, emphasizing the need for active sleep intervention strategies.
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Objective: This study seeks to investigate the relationship between Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) and hearing impairment by meta-analysis.

Methods: Cochrane Library, PubMed, Embase, Web of Science and other databases are searched from their establishment to July 1st, 2022. Literature on the relationship between OSAHS and hearing loss is collected, and two researchers independently perform screening, data extraction and quality evaluation on the included literature.

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Objective: The purpose of this meta-analysis is to systematically assess the effects of psychological intervention on empathy fatigue among nursing staff.

Method: Five electronic databases are searched separately from their establishment to April 8th, 2022. The research team independently performs paper selection, quality assessment, data extraction and analysis for all included studies.

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Article Synopsis
  • This study investigates the effectiveness of using the STOP-Bang questionnaire alongside the Epworth Sleepiness Scale (ESS) for detecting obstructive sleep apnea (OSA) in a patient population.
  • Data from 1,671 patients suspected of having OSA were analyzed through overnight polysomnography, revealing the diagnostic strengths and weaknesses of both screening tools.
  • The findings suggest that using a STOP-Bang score of ≥3 in combination with ESS enhances the screening’s specificity for OSA diagnosis and recommends further evaluation of patients with this score.
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A meta-analysis is used to explore the relationship between polycystic ovary syndrome (PCOS) and the risk of Sleep disturbances. Cochrane Library, PubMed, Embase, and Web of Science databases are searched by computer from their establishment to 1 May 2022. Review Manager 5.

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Mammalian protein arginine methyltransferase 3 (PRMT3) catalyzes the monomethylation and dimethylation of the arginine residues of proteins. The role of PRMT3 in renal fibrosis is currently unknown. We aimed to study the role of PRMT3 in renal fibrosis and explored its underlying mechanisms.

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