Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study.

Mutations in IDH1 are commonly observed across various cancers, causing the conversion of α-KG to 2-HG. Elevated levels of 2-HG disrupt histone and DNA demethylation processes, promoting tumor development. Consequently, there is substantial interest in developing small molecule inhibitors targeting the mutant enzymes.

miR-330-5p Suppress Cell Growth and Invasion via Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer.

Background: Recently, miRNAs are demonstrated to restrain mRNA translation through novel pattern with bind complementary sites in the coding sequence (CDS). Heat Shock Transcription Factor 4 (HSF4) has been newly described as a tumor-associated transcription factor. Therefore, the present study intends to explore miRNAs that bind CDS region of HSF4, and identify the function of their interactions in the malignant biological behavior of colorectal cancer (CRC).

Quantum illumination based on cavity-optomagnonics system with Kerr nonlinearity.

Quantum illumination is a quantum optical sensing technique, which employs an entangled source to detect low-reflectivity object immersed in a bright thermal background. Hybrid cavity-optomagnonics system promises to work as quantum illumination because a yttrium iron garnet (YIG) sphere can couple to microwave field and optical field. In this paper, we propose a scheme to enhance the entanglement between the output fields of the microwave and optical cavities by considering the intrinsic Kerr nonlinearity of the YIG.

High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh mA demethylation: a potential mechanism for diabetic cognitive dysfunction.

Tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. N-methyladenosine (mA) methylation is the most common modification of eukaryotic mRNA and is involved in regulating diverse biological processes. However, the role of mA alteration in tau hyperphosphorylation of hippocampus neurons has not been reported.

Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells suppressing NLRP3/caspase1-mediated pyroptosis.

Background: We investigated the level of Cysteine-rich 61 (CYR61) in premature ovarian failure as well as its regulatory molecular mechanism in this study.

Methods And Results: Cyclophosphamide (CTX) was used to induce OGCs (rat ovarian granulosa cells) and rats to establish in vivo and in vitro premature ovarian failure models. H&E staining was used to detect the pathological changes of ovarian histopathology.

Improving mechanical cooling by using magnetic thermal noise in a cavity-magnomechanical system.

The cavity-magnomechanical system is a significant platform for studying quantum information. In this paper, a scheme to realize the ground-state cooling of the mechanical phonon mode in a cavity-magnomechanical system is proposed. In the general cooling method, the system is usually driven by a strong pumping field, and the Hamiltonian of the system needs to be linearized.

Simulating topological phases with atom arrays in an optical waveguide.

In this paper, we employ the atomic arrays in one-dimensional optical waveguides to simulate topological phases, where the waveguide is modeled as a one-dimensional infinitely long coupled cavity array. Under the Markov approximation, the coherent and dissipative coupling between atoms is established by eliminating waveguide modes. When the detuning between atoms and cavity fields lies in the band gap, the dynamics of the system is completely dominated by the coherent interaction.

Unidirectional amplification in optomechanical system coupling with a structured bath.

Nonreciprocity plays an indispensable role in quantum information transmission. We theoretically study the unidirectional amplification in the non-Markovian regime, in which a nanosphere surrounded by a structured bath is trapped in a single (dual)-mode cavity. The global mechanical response function of the nanosphere is markedly altered by the non-Markovian structured bath through shifting the effective frequency and magnifying the response function.

Simultaneous ground-state cooling of identical mechanical oscillators by Lyapunov control.

The simultaneous cooling of multiple mechanical oscillators in the cavity optomechanical system has aroused people's attention and may be applicable in the quantum information process. In this paper, a scheme to realize the simultaneous ground-state cooling of two identical mechanical oscillators is proposed, where the frequency of one of the oscillators is designed according to Lyapunov control. By this method, the dark mode can effectively couple with the bright mode so that the two identical oscillators can be simultaneously cooled to their ground state.

Melatonin Protects Against Cyclophosphamide-induced Premature Ovarian Failure in Rats.

This study was designed to understand the efficacy and molecular cues of melatonin in cyclophosphamide(CTX)-induced premature ovarian failure (POF) in rats. Female SD rats were used to evaluate the potential effects of melatonin on the ovarian hormonal status, follicular development, and granulosa cells in CTX-treated rats. Here, we found that pretreatment with melatonin before CTX administration preserved the normal sex hormone levels, improved follicular morphology, and granulosa cell proliferation, and reduced apoptosis, as compared to the CTX treatment alone.

An Intelligent Rice Yield Trait Evaluation System Based on Threshed Panicle Compensation.

High-throughput phenotyping of yield-related traits is meaningful and necessary for rice breeding and genetic study. The conventional method for rice yield-related trait evaluation faces the problems of rice threshing difficulties, measurement process complexity, and low efficiency. To solve these problems, a novel intelligent system, which includes an integrated threshing unit, grain conveyor-imaging units, threshed panicle conveyor-imaging unit, and specialized image analysis software has been proposed to achieve rice yield trait evaluation with high throughput and high accuracy.

Favorable Genotypes of Type III Interferon Confer Risk of Dyslipidemia in the Population With Obesity.

Background: Studies have indicated that the chronic state of inflammation caused by obesity leads to dyslipidemia. However, how the polymorphisms involved in these inflammatory pathways affect the lipid metabolism in people with obesity is poorly understood. We investigated the associations of inflammation-related gene polymorphisms with dyslipidemia in individuals with obesity living in China.

Nonlinearity enhancement and photon blockade in hybrid optomechanical systems.

The nonlinear optomechanical coupling is an attracting characteristic in the field of optomechanics. However, the strength of single photon optomechanical coupling is still within weak coupling regime. Using the optomechanical coupling to achieve strong nonlinear interaction between photons is still a challenge.

Photon blockade by enhancing coupling via a nonlinear medium.

A significantly low value of the single-photon coupling constant is a major challenge in the creation of a single-photon source via photon blockade. Here, we propose a photon blockade scheme composed of a weakly second-order nonlinear medium with an optical parametric amplification in a low-frequency cavity. Unlike the traditional weakly coupled system, the effective coupling strength in the proposed scheme can be significantly higher than the decay rate of the cavity mode.

Ground-state cooling of mechanical oscillator via quadratic optomechanical coupling with two coupled optical cavities.

We present a scheme for the electromagnetically induced transparency (EIT)-like nonlinear ground-state cooling in a double-cavity optomechanical system in which an optical cavity mode is coupled parametrically to the square of the position of a mechanical oscillator, an additional auxiliary cavity is coupled to the optomechanical cavity. The optimum cooling conditions is derived, based on which the heating process can be well suppressed and the mechanical resonator can be cooled with an optimal effect to near its ground state through EIT-like cooling mechanism even in unresolved sideband regime. It is demonstrated by numerical simulations that not only the average phonon number of steady state is lower than that of single-cavity optomechanical system, but also the cooling rate is greatly faster than that of the linear optomechanical coupling due to the two-phonon cooling process in the quadratic coupling.

MiR-223 regulates proliferation and apoptosis of IL-22-stimulated HaCat human keratinocyte cell lines via the PTEN/Akt pathway.

Psoriasis, a chronic inflammatory skin disorder disease, is closely associated with hyperproliferation of keratinocytes. Upregulated miR-223 has been found in peripheral blood mononuclear cells from patients with psoriasis and from psoriatic skin. However, its role in keratinocytes remains unknown.

Removal of Pb2+, Hg2+, and Cu2+ by Chain-Like Fe3O4@SiO2@Chitosan Magnetic Nanoparticles.

In this paper, the chain-like core-shell structure Fe3O4@SiO2@Chitosan composite nanoparticles were synthesized by a two-step coating and following crosslinking glutaraldehyde on chitosan shell. The composite particles showed nearly monodisperse 105 sized particles with a core diameter of 80 nm and chitosan shell thickness of 12 nm. The synthesis conditions of the product were studied, and the morphology and properties of the composite nanoparticles were characterized by IR, XRD, TEM, SEM, EDS and VSM.

Pulmonary artery closure in combination with patch technique for treating congenital heart disease combined with large patent ductus arteriosus: A clinical study of 9 cases.

Objective: To document clinical experience of treating congenital heart disease combined with large patent ductus arteriosus with pulmonary artery closure in combination with patch technique.

Methods: Thirty-six patients (8 males and 28 females) who suffered from congenital heart disease and underwent hybrid surgery in the First Affiliated Hospital of Zhengzhou University from October 2010 to February 2014 were selected for this study. They aged 14 to 39 years and weighed 32.

Right coronary artery fistula misdiagnosed as right atrial cardiac myxoma: A case report.

The current study describes a case of right coronary artery fistula (CAF) misdiagnosed as right atrial myxoma (RAM). A 33-year-old man presented with a 13-year history of intermittent chest pain, and aggravation for 3 days. Echocardiography revealed an occupying lesion in the right atrium producing a partial dynamic tricuspid obstruction.

Cagelike mesoporous silica encapsulated with microcapsules for immobilized laccase and 2, 4-DCP degradation.

In this study, cage-like mesoporous silica was used as the carrier to immobilize laccase by a physical approach, followed by encapsulating with chitosan/alginate microcapsule membranes to form microcapsules of immobilized laccase based on layer-by-layer technology. The relationship between laccase activity recovery/leakage rate and the coating thickness was simultaneously investigated. Because the microcapsule layers have a substantial network of pores, they act as semipermeable membranes, while the laccase immobilized inside the microcapsules acts as a processing plant for degradation of 2,4-dichlorophenol.