Study of IsCT analogue peptide against and toxicity/teratogenicity in zebrafish embryos ().

An IsCT analogue peptide (PepM3) was designed based on structural studies of wasp mastoparans and tested against . Its effects on fungal cell membranes and toxicity were evaluated. Antifungal activity was analyzed using a microdilution susceptibility test.

COVID-19 and candiduria: an investigation of the risk factors and immunological aspects.

Secondary fungal infections are frequently observed in COVID-19 patients. However, the occurrence of candiduria in these patients and its risk factors are underexplored. We evaluated the risk factors of candiduria in COVID-19 patients, including inflammatory mediators that could be used as prognostic markers.

The impact of COVID-19 on antimicrobial prescription and drug resistance in fungi and bacteria.

Secondary infections are one of the complications in COVID-19 patients. We aimed to analyze the antimicrobial prescriptions and their influence on drug resistance in fungi and bacteria isolated from severely ill COVID-19 patients. Seventy-nine severely ill COVID-19 hospitalized patients with secondary bacterial or fungal infections were included.

Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals.

Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and and toxicity. The features of NLS-OG were analyzed by dynamic light scattering and showed adequate size (132.1 nm) and homogeneity (polydispersity index = 0.

Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against spp.

This study aimed to evaluate the activity of 2'-hydroxychalcone-loaded in nanoemulsion (NLS + 2'chalc), the cytotoxic effect and toxicity against and using a zebrafish model. Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2'chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the model.

Study of mastoparan analog peptides against and safety in zebrafish embryos ().

In this work, mastoparan analog peptides from wasp venom were tested against and safety assays were performed using cell culture and model zebrafish. Minimal inhibitory concentration was determined and toxicity was performed using human skin keratinocyte and embryo zebrafish. Also, permeation of peptides through embryo chorion was performed.

Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish.

Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants.

Materials & Methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model.

Applications of Invertebrate Animal Models to Dimorphic Fungal Infections.

Dimorphic fungi can be found in the yeast form during infection and as hyphae in the environment and are responsible for a large number of infections worldwide. Invertebrate animals have been shown to be convenient models in the study of fungal infections. These models have the advantages of being low cost, have no ethical issues, and an ease of experimentation, time-efficiency, and the possibility of using a large number of animals per experiment compared to mammalian models.

Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for and .

Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4-dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties. Nanostructured lipid systems (NLS) can potentiate the action of many antifungal agents, reducing the required dose and side effects by improving their activity. This work aimed to evaluate dodecyl protocatechuate loaded into a NLS (NLS+dodecyl) as a strategy for the treatment of and Antifungal activity against and was evaluated using the microdilution technique.