Differentiation of puerarin chelate from salt by phase solubility test.

Different from salt, metal chelate is a novel state of drug constructed by more separate coordinate bonds to form a chelating circle. Due to their composition similarity, it is hard to distinguish them except identifying ionic bond (i.e.

Are all poorly soluble drugs dissolved in deep eutectic solvents true solutions?

Hypothesis: The ability of deep eutectic solvents (DES) to enhance solubility of poorly soluble drugs has attracted increasing attention. Researchers have shown that drugs could be dissolved well in DES. In this study, we propose a new existence state of drugs in DES: a quasi-two-phase colloidal system.

Functionalized Bletilla striata polysaccharide micelles for targeted intracellular delivery of Doxorubicin: In vitro and in vivo evaluation.

Natural polysaccharides constitute promising material for nano-drug delivery systems (NDDS) due to their excellent biodegradability and biocompatibility. Previously, novel copolymer micelles (His-SA-BSP) were successfully engineered based on the functionalization of Bletilla striata polysaccharides (BSP) by histidine (His) and stearic acid (SA). In this work, the effectiveness of the designed micelles in selectively delivering Doxorubicin (Dox) to tumor cells is evaluated.

Negative Pressure Waves Based High Resolution Leakage Localization Method Using Piezoceramic Transducers and Multiple Temporal Convolutions.

The negative pressure wave (NPW) signals generated by a pipeline leakage often have a long signal duration. When these signals are utilized to compute the leakage position, the long signal duration will result in a large area being considered as leakage area. The localization resolution is low.

Novel pH-responsive and self-assembled nanoparticles based on polysaccharide: preparation and characterization.

In this investigation, innovative pH-sensitive and amphiphilic nanoparticles (NPs) were synthesized by grafting histidine (His, pH sensitive molecule) and stearic acid (SA, hydrophobic segment) onto the polysaccharides of (BSP). The His-SA-BSP was able to self-assemble into NPs with pH sensitivity. The acidic conditions could trigger the imidazole ionization and reverse the surface charge, while the electrostatic repulsion wrecked the structure and drove the NPs to a swollen state, as revealed by dynamic light scattering (DLS), transmission electron microscopy (TEM), and critical micelle concentration (CMC) analyses.

Ionic liquid - microemulsions assisting in the transdermal delivery of Dencichine: Preparation, in-vitro and in-vivo evaluations, and investigation of the permeation mechanism.

A novel microemulsion was developed and characterized for topical delivery of Dencichine (Den). Two imidazaolium ionic liquid, 1-hydroxyethyl-3-methylimidazolium chloride ([HOEIM]Cl) and 1-butyl-3-methylimidazolium dodecanesulfate ([BMIM]CSO) were incorporated into the aqueous and surfactant phases respectively for the remarkable enhancement on skin permeation. The nano-carrier was developed and optimized based on a pseudo-ternary phase diagram.

Association between pneumonia in acute stroke stage and 3-year mortality in patients with acute first-ever ischemic stroke.

The influence of pneumonia in acute stroke stage on the clinical presentation and long-term outcomes of patients with acute ischemic stroke is still controversial. We investigate the influence of pneumonia in acute stroke stage on the 3-year outcomes of patients with acute first-ever ischemic stroke. Nine-hundred and thirty-four patients with acute first-ever ischemic stroke were enrolled and had been followed for 3years.

[The application of trace element analysis to the study of provenance of copper minerals in ancient bronzes].

The simulated smelting and founding experiment of bronze showed that the copper minerals from different regions could be distinguished clearly by using the multi-statistical analysis based on choosing the chalcophile elements determined by ICP-AES. In the present paper, the data of trace elements in bronzes from Panlongcheng Site and Ezhou, which were determined by NAA, were tried to be processed. The analytical result showed that the bronzes from Panlongcheng and Ezhou could be divided clearly, just like the results of the former simulated smelting and founding experiment of bronze.