ERα phosphorylated at Ser309 participates in regulating luminal environment of efferent ducts and epididymis in mice.

The estrogen receptor alpha (ERα) plays an important role in male reproduction and fertility. Its activity is modulated by phosphorylation of multiple amino acid residues. The ERα phosphorylated at serine 305 (S305) in human cells (homologous with serine 309 in mice) induces ligand-independent ERα activity.

Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's disease.

Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms and treatments remain elusive. Here we report the therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model of Alzheimer's disease. Our findings reveal that light treatment prevents memory decline in 4-month-old 5xFAD mice and motivation loss in 14-month-old 5xFAD mice, accompanied by restoration of glial water channel aquaporin-4 polarity, improved brain drainage efficiency, and a reduction in hippocampal lipid accumulation.

Genome-wide identification and expression analysis of the cellulose synthase gene family in potato ( L.).

Potato () is the fourth largest staple food crop globally. However, potato cultivation is frequently challenged by various diseases during planting, significantly impacting both crop quality and yield. Pathogenic microorganisms must first breach the plant's cell wall to successfully infect potato plants.

Immune surveillance of brain metastatic cancer cells is mediated by IFITM1.

Brain metastasis, most commonly originating from lung cancer, increases cancer morbidity and mortality. Although metastatic colonization is the rate-limiting and most complex step of the metastatic cascade, the underlying mechanisms are poorly understood. Here, in vivo genome-wide CRISPR-Cas9 screening revealed that loss of interferon-induced transmembrane protein 1 (IFITM1) promotes brain colonization of human lung cancer cells.

A novel room-temperature formaldehyde gas sensor based on walnut-like WO modification on Ni-graphene composites.

Ternary composite with great modulation of electron transfers has attracted a lot of attention from the field of high-performance room-temperature (RT) gas sensing. Herein, walnut-like WO-Ni-graphene ternary composites were successfully synthesized by the hydrothermal method for formaldehyde (HCHO) sensing at RT. The structural and morphological analyses were carried out by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS).

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice.

The wide spread of coronavirus disease 2019 (COVID-19) has significantly threatened public health. Human herd immunity induced by vaccination is essential to fight the epidemic. Therefore, highly immunogenic and safe vaccines are necessary to control SARS-CoV-2, whose S protein is the antigenic determinant responsible for eliciting antibodies that prevent viral entry and fusion.

Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes.

Circadian control allows organisms to anticipate and adapt to environmental changes through changes in physiology and behavior. The circadian system timing is entrained by cues, such as light, food, and temperature. An ambient temperature dramatically impacts the sleep-wake cycle and metabolic rhythmicity.

Ghrelin is associated with anti-mullerian hormone levels in Chinese systemic lupus erythematosus.

Problem: Ghrelin has been thought of as a potential link between energy homeostasis and fertility. The aim of this study was to evaluate levels of ghrelin in obese and non-obese systemic lupus erythematosus (SLE) patients, and to reveal a possible association between ghrelin and Anti-Mullerian hormone (AMH) in SLE patients.

Method Of Study: One hundred SLE patients (50 obese and 50 non-obese subjects) at childbearing age and 100 age-matched healthy controls (50 obese and 50 non-obese subjects) were included.

40-Hz Blue Light Changes Hippocampal Activation and Functional Connectivity Underlying Recognition Memory.

Research on light modulation has typically examined the wavelength, intensity, and exposure time of light, and measured rhythm, sleep, and cognitive ability to evaluate the regulatory effects of light variables on physiological and cognitive functions. Although the frequency of light is one of the main dimensions of light, few studies have attempted to manipulate it to test the effect on brain activation and performance. Recently, 40-Hz light stimulation has been proven to significantly alleviate deficits in gamma oscillation of the hippocampus caused by Alzheimer's disease.

A p-n Heterojunction Based Pd/PdO@ZnO Organic Frameworks for High-Sensitivity Room-Temperature Formaldehyde Gas Sensor.

As formaldehyde is an extremely toxic volatile organic pollutant, a highly sensitive and selective gas sensor for low-concentration formaldehyde monitoring is of great importance. Herein, metal-organic framework (MOF) derived Pd/PdO@ZnO porous nanostructures were synthesized through hydrothermal method followed by calcination processes Specifically, porous Pd/PdO@ZnO nanomaterials with large surfaces were synthesized using MOFs as sacrificial templates. During the calcination procedure, an optimized temperature of 500°C was used to form a stable structure.

Bubble-Liquid Membrane Method for Preparing Spherical Calcium Carbonate Nanoparticles.

In this work, we describe the principle and operation of a bubble-liquid membrane reactor, and use of the reactor to prepare spherical calcium carbonate nanoparticles. The products were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and laser particle size analysis. The effects of additives to control crystal morphology, coating agents, and the stirring speed of the bubble-liquid membrane reactor were investigated.

An Astragalus membranaceus based eco-friendly biomimetic synthesis approach of ZnO nanoflowers with an excellent antibacterial, antioxidant and electrochemical sensing effect.

Nowadays featuring outstanding eco-friendliness, the phytochemical fabrication method of nanostructures is very popular. Here, we propose to utilize the Astragalus membranaceus extract as the reducing and capping agent to stabilize the metal and to avoid the aggregations of nanoparticles during ZnO nanoflowers synthesis procedure. As a result, the whole fabrication procedure was highly efficient and cost-effective without requiring a special environment of high pressure or elevated temperature and without chemical hazards used or produced.

Non-invasive 40-Hz Light Flicker Ameliorates Alzheimer's-Associated Rhythm Disorder via Regulating Central Circadian Clock in Mice.

Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings were conducted to examine the circadian clock rhythm in APP/PS1 mice.

Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure Improving SIRT1 and the Circadian Clock in the Liver-Brain Axis.

Sirtuin 1 (SIRT1) is a protein deacetylase with important cellular functions, as it regulates numerous processes, including the circadian rhythm in peripheral tissues. Efforts are ongoing to reveal how Sirt1 can be used to treat diseases, such as alcoholic liver disease (ALD), Alzheimer's disease, and liver fibrosis. We have recently shown that noninvasive exposure to 40-Hz light flicker activates hypothalamic SIRT1 gene expression, thereby regulating the central circadian clock.

AQP1 suppression by ATF4 triggers trabecular meshwork tissue remodelling in ET-1-induced POAG.

Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness worldwide. Increased endothelin-1 (ET-1) has been observed in aqueous humour (AH) of POAG patients, resulting in an increase in the out-flow resistance of the AH. However, the underlining mechanisms remain elusive.

Docetaxel-loaded PAMAM-based poly (γ-benzyl-l-glutamate)-b-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles in human breast cancer and human cervical cancer therapy.

Taxane-based chemotherapy-loaded drug delivery systems have great potential for cancer treatment. The docetaxel (DTX)-loaded PAMAM-based poly (γ-benzyl-l-glutamate)-b-d-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PBLG-b-TPGS) nanoparticles and the docetaxel (DTX)-loaded PAMAM-based poly (γ-benzyl-l-glutamate) (PAM-PBLG) nanoparticles were designed using a modified nanoprecipitation method. The particle size, encapsulation efficiency (EE), and release characteristics of the nanoparticles were tested.

Effects of Ghrelin on the Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocyte MH7A Cells.

Ghrelin is a circulating peptide hormone, which involved in promoting feeding and regulating energy metabolism in human and rodents. Abnormal synovial hyperplasia is the most important pathologic hallmark of rheumatoid arthritis (RA), which is characterised by tumor-like expansion. Existing studies indicated that there may exist some relation between the decreased ghrelin and the abnormally proliferating synovial cells in RA.

Directional coupler based on an elliptic cylindrical nanowire hybrid plasmonic waveguide.

We present what we believe is a novel directional coupler based on an elliptic cylindrical nanowire hybrid plasmonic waveguide. Using the finite element method, the electric field distributions of y-polarized symmetric and antisymmetric modes of the coupler are compared, and the coupling and transmission characteristics are analyzed; then the optimized separation distance between the two parallel waveguides, 100 nm, is obtained. This optimized architecture fits in the weak coupling regime.

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis.

Background: The role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial.

Objectives: The primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls.

Methods: Bibliographic searches were conducted in three electronic databases.

Elliptic cylindrical silicon nanowire hybrid surface plasmon polariton waveguide.

We researched an elliptic cylindrical silicon nanowire hybrid surface plasmon polariton waveguide and evaluated its mode characteristics using the finite element method software COMSOL. The waveguide consists of three parts: an elliptic cylindrical silicon nanowire, a silver film layer, and a silica covering layer between them. All of the components are surrounded by air.

Molecular identification and phylogenetic study of Demodex caprae.

The DNA barcode has been widely used in species identification and phylogenetic analysis since 2003, but there have been no reports in Demodex. In this study, to obtain an appropriate DNA barcode for Demodex, molecular identification of Demodex caprae based on mitochondrial cox1 was conducted. Firstly, individual adults and eggs of D.

Molecular identification of four phenotypes of human Demodex in China.

Traditional classification of Demodex mites by hosts and phenotypic characteristics is defective because of environmental influences. In this study, we proposed molecular identification of four phenotypes of two human Demodex species based on mitochondrial cox1 fragments for the first time. Mites collected from sufferers' facial skin were classified into four phenotypes: phenotype A-C with finger-like terminus, and phenotype D with cone-like terminus.