Purpose: To develop a deep learning-based approach to reduce the scan time of multipool CEST MRI for Parkinson's disease (PD) while maintaining sufficient prediction accuracy.
Method: A deep learning approach based on a modified one-dimensional U-Net, termed Z-spectral compressed sensing (CS), was proposed to recover dense Z-spectra from sparse ones. The neural network was trained using simulated Z-spectra generated by the Bloch equation with various parameter settings.