Bi-directional effects between inflammatory molecules and intracranial aneurysm.

Introduction: Although inflammation is closely associated with the pathogenesis of intracranial aneurysm (IA), detailed causal associations remain unclear. This study aimed to investigate the causality between circulating inflammatory molecules (IMs) and IA.

Materials And Methods: The bi-directional Mendelian randomization (MR) analysis was conducted using two genome-wide association studies (GWAS) for inflammatory molecules (IMs) from Finnish and Icelandic populations, as well as GWAS datasets of IA cases and controls of European descent.

Simvastatin reduces chronic kidney disease and renal failure risk in type 2 diabetes patients: post hoc ACCORD trial analysis.

Objective: Type 2 diabetes mellitus (T2DM) poses a substantial global health concern. Statins are widely used among T2DM patients for managing dyslipidemia, preventing cardiovascular disease (CVD), and offering renal protection. However, the extent to which their renal protective effects contribute to reducing the incidence of severe renal complications, including chronic kidney disease (CKD) and renal failure, is not well-defined.

Treatment of intracranial aneurysms using the Tubridge flow diverter.

Objective: The Tubridge flow diverter (TFD) was recently developed to treat intracranial aneurysm (IA). In this study, we aimed to assess the safety and efficacy of this novel device.

Methods: A retrospective cohort of consecutive patients with IA was recruited between June 2017 and February 2022.

Female hormonal and reproductive factors and the risk of subarachnoid hemorrhage.

Background: Subarachnoid hemorrhage (SAH), primarily caused by rupture of intracranial aneurysm, has a high incidence rate in women. We aimed to evaluate the association between female hormonal and reproductive factors and SAH.

Methods: A prospective cohort of 226,469 participants from the UK Biobank was followed for a median period of 14.

[Spatio-temporal Variation in NEP in Ecological Zoning on the Loess Plateau and Its Driving Factors from 2000 to 2021].

Net ecosystem productivity (NEP) is an important index for the quantitative evaluation of carbon sources and sinks in terrestrial ecosystems. Based on MOD17A3 and meteorological data, the vegetation NEP was estimated from 2000 to 2021 in the Loess Plateau (LP) and its six ecological subregions of the LP (loess sorghum gully subregions:A1, A2; loess hilly and gully subregions:B1, B2; sandy land and agricultural irrigation subregion:C; and earth-rock mountain and river valley plain subregion:D). Combined with the terrain, remote sensing, and human activity data, Theil-Sen Median trend analysis, correlation analysis, multiple regression residual analysis, and geographic detector were used, respectively, to explore the spatio-temporal characteristics of NEP and its response mechanism to climate, terrain, and human activity.

Temperature and moisture sensitivities of soil respiration vary along elevation gradients: An analysis from long-term field observations.

Based on long-term field observation data over 11 years at 23 sites in two mountainous areas (TS1 and TS2) at elevations from 829 to 2700 m, where the dominant vegetation type of TS1 and TS2 was temperate mixed broadleaf-coniferous forest and cold temperate coniferous forest, respectively, we analyzed the correlations between soil respiration (R) and abiotic and biotic factors to explore the response patterns of R to environmental factors within and between the sites along the elevation gradient. We found that soil moisture (θ) and its combinations (T × θ and θ/T) with soil temperature (T) increased significantly with increasing elevation, while T, soil bulk density (SBD), C/N ratio, and pH decreased significantly with increasing elevation. Within each site, both exponential- T (ET) and Gaussian-T (GT) models could be used for predicting the R seasonal variation, except for two sites in the area of TS1, where θ was a better predictor than T.

Disease burden based on gender and age and risk factors for stroke in China, 2019.

Objectives: Stroke has become the leading cause of death and disability among adults in China. This study aims to analyze the disease burden based on gender and age and the risk factors for stroke subtypes in China 2019, and to provide reference for targeted stroke prevention and control.

Methods: Based on 2019 data of the Global Burden of Disease (GBD), the gender and age in patients with different stroke subtypes (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage) in China 2019 was described by using disability-adjusted life years (DALY), and attributable burden of related risk factors was analyzed.

Flow-diverter stents in intracranial aneurysm treatment: impact on covered cerebral artery branches.

Objective: Flow diverter stents (FDSs) have attracted interest for intracranial aneurysm (IA) treatment; however, occlusion of side branches and related complications have been reported. This study aimed to investigate the effects of FDSs in IA management when different branches of intracranial arteries are covered.

Materials And Methods: A cross-sectional study was conducted using PUBMED, Embase, Web of Science, and Cochrane databases to include randomized or nonrandomized comparative-designed studies from January 2000 to August 2022 which reported outcomes of occlusion/narrowing of branches after IA treatment using FDSs.

Short-term environmental triggers of hemorrhagic stroke.

Hemorrhagic stroke (HS) is associated with severe morbidity and high mortality. Identifying the trigger factors for HS is critical for disease prevention. This study aimed to assess the associations between short-term environmental triggers (STETs) and HS risk.

Individual trigger factors for hemorrhagic stroke: Evidence from case-crossover and self-controlled case series studies.

Background: Hemorrhagic stroke (HS) is a sudden-onset disease with high mortality and disability rates, and it is crucial to explore the triggers of HS. In this study, we analyzed individual triggers for HS to provide a basis for HS prevention and intervention.

Methods: A systematic search of five databases was conducted until December 2022.

Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis.

Background: Variants in organic cation transporter (OCT) genes play a crucial role in metformin pharmacokinetics and are critical for diabetes treatment. However, studies investigating the effect of OCT genetic polymorphisms on metformin response have reported inconsistent results. This review and meta-analysis aimed to evaluate the associations between OCT genetic polymorphisms and metformin response and intolerance in individuals with type 2 diabetes mellitus (T2DM).

Stroke Following Coronavirus Disease 2019 Vaccination: Evidence Based on Different Designs of Real-World Studies.

Background: We aimed to evaluate whether coronavirus disease 2019 (COVID-19) vaccination was associated with stroke.

Methods: We conducted a systematic meta-analysis of studies using cohort, self-controlled case series (SCCS), and case-crossover study (CCOS) designs to evaluate incidence risk ratios (IRRs) and 95% confidence intervals (CIs) of ischemic stroke (IS), hemorrhagic stroke (HS), and cerebral venous sinus thrombosis (CVST) following COVID-19 vaccination. Risks of stroke were pooled among subpopulations categorized by vaccine type, dose, age, and sex.

Association of insulin signaling pathwayrelated gene polymorphisms and genegene interactions with MAFLD in obese children.

Objectives: Insulin signaling pathway plays an important role in metabolic associated fatty liver disease (MAFLD), however, the association between polymorphisms of genes related to insulin signaling pathway and MAFLD remains unclear. This study aims to investigate the association between insulin signaling pathway-related gene polymorphisms and gene-gene interactions with MAFLD susceptibility in obese children so as to provide scientific basis for further study of genetic mechanism.

Methods: A total of 502 obese children with MAFLD who admitted to Hunan Provincial Children's Hospital from September 2019 to October 2021, were recruited as a case group, and 421 obese children with non-MAFLD admitted during the same period were recruited as a control group.

Behavioral trigger factors for hemorrhagic stroke: a case-crossover study.

Background: The role and extent of the effects of short-term behavioral factors on the risk of hemorrhagic stroke (HS) are unclear. This study aimed to assess and quantify behavioral trigger factors (BTFs) for HS and identify the differences in BTFs between Chinese and other populations.

Methods: A case-crossover study was performed from March 2021 to February 2022.

Methodological quality assessment of genetic studies on brain arteriovenous malformation related hemorrhage: A cross-sectional study.

Rupture of a brain arteriovenous malformation (bAVM) can cause intracranial hemorrhage and severe clinical outcomes. At present, the mechanisms of bAVM-related hemorrhage are poorly understood. This study aimed to summarize the potential genetic risk factors for bAVM-related hemorrhage and appraise the methodological quality of existing genetic studies on bAVM-related hemorrhage using a cross-sectional design.

Research on Spatio-Temporal Characteristics of Tourists' Landscape Perception and Emotional Experience by Using Photo Data Mining.

Mountainous scenic spots are important tourism resources, and the study of tourists' landscape perception and emotional preference when visiting them is beneficial to the management of scenic spots in order to improve the service quality and promote the protection, development, and utilization of scenic resources. In this paper, we use the location photo data of tourists at Huangshan Mountain to extract the visual semantic information of location photos, calculate the photo sentiment value, and mine the landscape perception and sentiment preference features of tourists using DeepSentiBank image recognition model and photo visual semantic quantification method. The results show the following: (1) Huangshan tourists mainly focus on nine types of photos, with the most attention paid to the category of mountain rock landscapes and the least attention paid to the category of animal landscapes.

Association of rare variants and intracranial aneurysm risk in a Chinese population.

Background: Genetic factors play important roles in the development of intracranial aneurysm (IA). Rare variants have been identified as being susceptible to Moyamoya disease (MMD), non-MMD intracranial artery stenosis/occlusion disease, and other vascular disorders. This study aimed to investigate the association between rare variants and the risk of IA in a Chinese population.

Haemorrhage risk of brain arteriovenous malformation during pregnancy and puerperium.

Background: This study aimed to assess whether pregnancy and puerperium were associated with the risk of brain arteriovenous malformation (bAVM) haemorrhage.

Methods: A retrospective review was conducted in Xiangya Hospital, Central South University from January 2012 to December 2021. A case-crossover design was adopted to calculate the incidence density of bAVM-related haemorrhage among female patients in risk (pregnancy and puerperium) and control (non-pregnancy and non-puerperium) periods, according to four scenarios observed in different populations (scenario I: patients with haemorrhagic bAVM of all ages; scenario II: patients with haemorrhagic bAVM of all ages, with at least one previous pregnancy; scenario III: patients with haemorrhagic bAVM who are of reproductive age (15-45 years); scenario IV: patients with haemorrhagic bAVM of reproductive age (15-45 years), with at least one previous pregnancy.

Genetic regulation of methylation in diabetic retinopathy.

Background: Diabetic retinopathy (DR) is a common and serious microvascular complication of diabetes mellitus (DM), but its pathological mechanism, especially the formation mechanism of new blood vessels remains unclear. Thrombospondin-1 () is a potent endogenous inhibitor of angiogenesis and it was found over expressed in DR in our previous study. Our study aimed to determine whether overexpression of is associated with its promoter methylation level, and whether methylation of is regulated by genetic variants in DR.

Prevalence and associated influential factors of mental health problems among Chinese college students during different stages of COVID-19 pandemic: A systematic review.

This systematic review aims to take China as an example to determine the prevalence of mental health problems and associated influential factors of college students in different stages of the COVID-19 pandemic and provide a reference for effective intervention in the future. A systematic search was conducted on PubMed, Web of Science, Scopus, Science Direct, and Google scholar. A total of 30 articles were included.

Lysyl oxidase family gene polymorphisms and risk of aneurysmal subarachnoid hemorrhage: a case-control study.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease caused by intracranial aneurysm (IA) rupture. Lysyl oxidase () family genes () have roles in collagen cross-linking in the extracellular matrix (ECM) and may be associated with IA rupture. We aimed to explore the association between polymorphisms and the risk of aSAH.

[Detection of Influencing Factors of Spatial Variability of Soil Respiration in Pangquangou Nature Reserve].

Soil respiration is an important process in maintaining global carbon balance. Taking the Pangquangou Nature Reserve as the research area, based on the field measurement of soil respiration () data combined with altitude (ELE), soil temperature (), soil moisture (SWC), normalized vegetation index (NDVI), slope (slope), soil total carbon (C), total nitrogen (N), and soil bulk density (BD), we analyzed the main driving forces and interactions of spatial differentiation by using the geographic detector model. The results showed that:① the spatial variation of and its influencing factors in the study area was moderate.

Mechanical Properties of TC11 Titanium Alloy and Graphene Nanoplatelets/TC11 Composites Prepared by Selective Laser Melting.

Titanium matrix composites (TMCs) with excellent mechanical properties, reinforced by graphene, is deemed the lightweight and high strength structural materials. In this study, TC11 titanium alloy powder and graphene nanosheets (GNPs) were used as raw materials, and the composite powder with good uniformity and fluidity was obtained through non-interventional homogeneous mixing by a planetary mixer. The microstructure and mechanical properties of the GNPs-TC11 composites and TC11 alloy were compared.

Associated genetic variants and potential pathogenic mechanisms of brain arteriovenous malformation.

Background: The pathogenic mechanism of brain arteriovenous malformation (bAVM) is poorly understood. A growing body of evidence indicates that genetic factors play crucial roles in bAVM. This study examined genetic variants associated with bAVM through quantitative synthesis and qualitative description of literature.