Nephrotoxicity of Immune Checkpoint Inhibitors: A Disproportionality Analysis from 2013 to 2020.

Nephrotoxicity occasionally occurs during treatment with immune checkpoint inhibitors (ICIs). Few related studies compare the differences between these drugs. This study aimed to systematically characterize nephrotoxicity after ICI initiation.

GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78.

Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GALNT6) in lung adenocarcinoma is associated with lymph node metastasis and poor prognosis.

Protein Corona-Triggered Catalytic Inhibition of Insufficient POSS Polymer-Caged Gold Nanoparticles for Sensitive Colorimetric Detection of Metallothioneins.

Metallothioneins (MTs) are important biomarkers for the early diagnosis of heavy metal poisoning and malignancies. Convenient and cost-effective approaches for the rapid detection of MTs are therefore highly desirable for clinical monitoring. Herein, by taking advantage of the enzyme-mimetic activity of nanoparticles and protein corona-based recognition, insufficient polyhedral oligomeric silsesquioxane (POSS) polymer-caged gold nanoparticles (denoted as PP-AuNPs) are developed for the sensitive colorimetric analysis of MTs.

M2 macrophages promote NSCLC metastasis by upregulating CRYAB.

The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment to assess TAM effects on invasion and metastasis in NSCLC. The results showed lung carcinoma cells could cause macrophages to show the M2 (a TAM-like) phenotype, and these M2 macrophages promoted lung cancer cell EMT and invasion.

AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model.

Brain metastasis (BM) is a leading cause of mortality in patients with non-small cell lung cancer (NSCLC). However, the molecular mechanisms underlying BM of NSCLC remain largely unknown because of the lack of models to accurately investigate such a dynamic and complex process. Here we developed a multi-organ microfluidic chip as a new methodological platform to study BM.

Discrimination and highly selective adsorption of phosphoproteins and glycoproteins with arginine-functionalized polyhedral oligomeric silsesquioxane frameworks.

The crosstalk between phosphoproteins and glycoproteins causes many difficulties in their selective isolation/enrichment from biological samples. This issue is of high significance in proteomics study, but thus far, it has not received proper attention. Herein, an arginine-functionalized polyhedral oligomeric silsesquioxane (POSS) framework, PP-x-Arg (x = 0, 1, 2, … denotes the amount of salt in preparation), was developed by combining salt-templated thermal polymerization of POSS and pyromellitic dianhydride (PMDA) with post-modification using arginine.

Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.

DNA methyltransferase 1 (DNMT1) plays a significant role in maintaining DNA methylation. Aberrant DNA methylation is a recognized feature of human cancers and folate is directly involved in DNA methylation via one-carbon metabolism. Previous reports also have suggested that folate deficiency was associated with many cancers.

[Interaction of folate deficiency and aberrant profile of DNA methyltransferase 1 in the progression of cervix carcinogenesis].

Objective: To explore the interaction of folate deficiency and aberration of DNA methyltransferase 1 (DNMT1) in the progression of cervix carcinogenesis.

Methods: All clinical samples were collected from 80 patients with cervix squamous cell carcinoma (SCC), 105 patients with cervical intraepithelial neoplasm (CINI, n = 52; CINII/III, n = 53) and 53 patients with cervix inflammation (CI). The participants were diagnosed by histology at Shanxi Province Tumor Hospital and Second Hospital of Shanxi Medical University during the period of September 2009 to May 2010.

[Effect of bisphenol A exposure on sex hormone level in occupational women].

Objective: To explore the effect of bisphenol A (BPA) exposure on sex hormone levels in occupational women.

Methods: 51 women workers with at least a year of BPA exposure and 104 women workers without BPA exposure were chosen to do a case; control study. The information in general population characteristics, exposure, menstruation state, etc and the venous blood samples on an empty stomach were collected for the two groups.

Preparation of poly(vinyltetrazole) chain-grafted poly(glycidymethacrylate-co-ethylenedimethacrylate) beads by surface-initiated atom transfer radical polymerization for the use in weak cation exchange and hydrophilic interaction chromatography.

A novel stationary phase for weak cation exchange (WCX) and hydrophilic interaction chromatography (HILIC) was prepared with surface-initiated atom transfer radical polymerization (SI-ATRP). Vinyltetrazole was grafted onto the surface of the beads in water medium with the polyglycidylmethacrylate beads (P(GMA/EDMA)) previously modified with 2-bromoisobutryl bromide as the macromolecule initiators and CuCl as catalyst. The poly(vinyltetrazole)-grafted beads obtained with different atom transfer radical polymerization (ATRP) formulations were tried as chromatographic packings in ion-exchange chromatography.

The relationship between left ventricular hypervoltage and CYP11B2 (344T/C) polymorphism in Keriyans.

Introduction: The 'desert people' or Keriyans are able to maintain normal body functions whilst living in the hot, arid areas of Taklimakan Desert. However, little is known about the adaptive mechanisms in this extreme environment. We explored the relationship between polymorphism of C-344T in the promoter region of the aldosterone synthase gene (CYP11B2) and resting electrocardiogram (ECG) hypervoltage in this population.