Publications by authors named "Junwen Li"

Ethnopharmacological Relevance: Beaveria bassiana (Balsamo) Vuillemin (BEA) and cinnamaldehyde (CA), primarily derived from traditional Chinese medicine (TCM) named Bombyx batryticatus and Cinnamomum cassia, play an immunomodulatory role in different disease.

Aim Of The Study: Hepatocellular carcinoma (HCC) is a prevalent malignant tumor characterized by immune dysfunction. In this study, we investigated BEA and CA's regulate ability on T cell mitochondrial metabolism and anti-HCC effect.

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For antibiotic-enriched waste activated sludge, classical iron-based chemical conditioning significantly enhanced sludge dewaterability. Nevertheless, the intricate constituents within sludge rapidly depleted reactive oxygen species (ROS), leading to challenges such as excessive production of iron sludge and inadequate elimination of antibiotics from sludge. Herein, we proposed an innovative strategy integrating biochar with Fe(II) for peroxymonosulfate (PMS) activation, aiming to enhance both sludge dewaterability and antibiotics elimination simultaneously.

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Article Synopsis
  • Aquatic environments contain antibiotic-resistant bacteria, but the specific presence of polymyxin-resistant Yersinia enterocolitica, which causes yersiniosis, is not well-studied until now.
  • Researchers isolated polymyxin-resistant strains from natural water, showing resistance to multiple antibiotics and a high capability to cause disease in the model organism Galleria mellonella, leading to a 90% mortality rate within 48 hours.
  • Whole genome sequencing revealed 26 antibiotic resistance genes and a close genetic relationship to strains from humans and swine, indicating that polymyxin-resistant Y. enterocolitica could be a significant health threat to humans.
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Human noroviruses (HuNoVs), the most prevalent viral contaminant in food, account for a substantial proportion of nonbacterial gastroenteritis cases. Extensive work has been focused on the diagnosis of HuNoVs in clinical samples, whereas the availability of sensitive detection methods for their detection in food is lacking. Here, we developed a virus enrichment approach utilizing graphene-based nanocomposites (CTAB-rGO-FeO) that does not rely on large instruments and is suitable for on-site food pretreatment.

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Due to the strong pathogenicity of hypervirulent Klebsiella pneumoniae (hvKP), its performance against disinfectants in water should be understood to protect public health and ecological environment. Unfortunately, the disinfectant tolerance of hvKP with a hypermucoviscosity (HMV) phenotype is a critical underexplored area. Here, the tolerance of K.

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Due to its abundance, high theoretical capacity, and environmental benefits, tin dioxide (SnO) shows great potential as an anode material in sodium-ion batteries (SIBs). However, the inadequate electrical conductivity and significant volume fluctuations during the Na insertion/extraction process are major limitations to its practical application. Herein, few-layered MoS@SnO@C (FMSC) composites with hierarchical nanostructures were prepared through a two-step hydrothermal method.

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In this study, the variations in hydrogen content and oxide content in alloys under 0 W, 500 W, 1000 W, 1500 W, 2000 W, 2500 W, 3000 W, and at 20 kHz, 30 kHz, 40 kHz were investigated. Hydrogen content was assessed using porosity and computed tomography, while oxygen content in the alloy was measured using element analyzer and elemental scanning. Compared to other conditions, the melt had the lowest hydrogen and oxide contents at a frequency of 20 kHz and an ultrasonic power of 2500 W, with values of 0.

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Groundwater on the Tibetan Plateau is a critical water resource to people in Asia. However, its prevalence of antibiotic-resistant pathogens (ARPs), bacterial resistome and their driving factors remain unknown. Using metagenomics analysis, a hotspot of antibiotic-resistance genes (ARGs) and last-resort ARGs (LARGs) with a total of 639 subtypes was identified in the groundwater.

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Upland cotton accounts for a high percentage (95%) of the world's cotton production. Plant height (PH) and branch number (BN) are two important agronomic traits that have an impact on improving the level of cotton mechanical harvesting and cotton yield. In this research, a recombinant inbred line (RIL) population with 250 lines developed from the variety CCRI70 was used for constructing a high-density genetic map and identification of quantitative trait locus (QTL).

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Cadmium (Cd) is a ubiquitous pollutant that poses a potential threat to human health. Monitoring Cd(II) in drinking water has significant implications for preventing potential threats of Cd(II) to human. However, the weak signal output and response to nontarget interference limit the detection of Cd(II) using bacterial biosensors.

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Background: Work-related musculoskeletal disorders significantly impact the job performance and quality of life of nursing personnel in China, necessitating an understanding of their prevalence and risk factors to enhance occupational health and improve medical safety.

Objective: To systematically evaluate the prevalence and risk factors of work-related musculoskeletal disorders among clinical nurses in China.

Design: Systematic literature review and meta-analysis.

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Article Synopsis
  • Stenotrophomonas maltophilia, found in aquatic environments, presents significant health risks for immunocompromised individuals due to its ability to resist multiple antibiotics and its associated high mortality rates.
  • This study identified nine colistin-resistant strains of S. maltophilia from natural lakes, revealing new sequence types (ST965 and ST966) and significant biofilm formation and virulence compared to the known ST532 strain.
  • Genome analysis highlighted key genetic determinants of antibiotic resistance, indicating that these newly discovered strains could potentially pose serious health risks to humans due to their higher virulence and antibiotic resistance profiles.
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Nanopore sequencing is extremely promising for the high-throughput detection of pathogenic bacteria in natural water; these bacteria may be transmitted to humans and cause waterborne infectious diseases. However, the concentration of pathogenic bacteria in natural water is too low to be detected directly by nanopore sequencing. Herein, we developed a mica filter to enrich over 85% of bacteria from > 10 L of natural water in 100 min, which led to a 10-fold improvement in the assay limits of the MinION sequencer for assessing pathogenic bacteria.

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There is growing concern about the transfer of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in airborne particulate matter. In this study, we investigated the effects of various types of carbonaceous particulate matter (CPM) on the transfer of ARGs . The results showed that CPM promoted the transfer of ARGs, which was related to the concentration and particle size.

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Article Synopsis
  • * Researchers found that mitochondrial function in PBMCs was significantly lower in lung cancer patients and that exposure to a carcinogen called BaP led to mitochondrial dysfunction in both mice and cultured cells.
  • * The findings suggest that monitoring mitochondrial function in PBMCs could serve as a helpful prognostic marker or a potential target for improving treatment outcomes in lung cancer patients.
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Chlorine-resistant bacteria (CRB) in drinking water treatment plants (DWTPs) jeopardize water quality and pose a potential risk to human health. However, the specific response of CRB to chlorination and chloramination remains uncharacterized. Therefore, we analyzed 16 S rRNA sequencing data from water samples before and after chlorination and chloramination taken between January and December 2020.

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Upland cotton is the fifth-largest oil crop in the world, with an average supply of nearly 20% of vegetable oil production. Cottonseed oil is also an ideal alternative raw material to be efficiently converted into biodiesel. However, the improvement in kernel oil content (KOC) of cottonseed has not received sufficient attention from researchers for a long time, due to the fact that the main product of cotton planting is fiber.

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Article Synopsis
  • Upland cotton is a key crop for the textile industry, but improving both fiber quality and yield is challenging due to their negative correlations under current breeding conditions.
  • The study aimed to identify quantitative trait loci (QTLs) to understand how they influence fiber quality and yield using a detailed genetic map of a specific cotton population.
  • Results showed the identification of 295 QTLs, including stable ones linked to fiber traits and candidate hub genes; notably, the gene GhCesA4 was found to enhance fiber length and strength while reducing lint percentage.
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Fiber quality traits, especially fiber strength, length, and micronaire (FS, FL, and FM), have been recognized as critical fiber attributes in the textile industry, while the lint percentage (LP) was an important indicator to evaluate the cotton lint yield. So far, the genetic mechanism behind the formation of these traits is still unclear. Quantitative trait loci (QTL) identification and candidate gene validation provide an effective methodology to uncover the genetic and molecular basis of FL, FS, FM, and LP.

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. Sleep staging is the basis for sleep quality assessment and diagnosis of sleep-related disorders. In response to the inadequacy of traditional manual judgement of sleep stages, using machine learning techniques for automatic sleep staging has become a hot topic.

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Beauvericin is a world-spread mycotoxin isolated from the traditional Chinese medicine, Bombyx batryticatus (BB), which has been widely used to treat various neoplastic diseases. This study investigated the anti-hepatocellular carcinoma (HCC) activity of beauvericin and its potential mechanism. In this study, H22-bearing mice were intraperitoneally injected with 3, 5, 7 mg/kg of beauvericin once per-week over a three-week period.

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Groundwater is a vital source of drinking water for Tibetans. Antibiotic resistance genes (ARGs) and bacterial communities in groundwater on the Tibetan Plateau remain unclear. Furthermore, the characterization of their differences between high-altitude and low-altitude groundwater is still unrevealed.

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People who engage in water sports in recreational marine water may be at high risk of exposure to hazardous antibiotic-resistant bacteria (ARB). However, information on the contribution of specific sources to ARB contamination in recreational marine water is still lacking. Here, we carried out monthly analyses of antibiotic resistance genes (ARGs), pathogenic bacteria and 16S rRNA sequencing data at the First Bathing Beach in Qingdao.

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To study the effects of Cistanche deserticola and its active components Cistanche deserticola polysaccharide and Echinacoside on intestinal flora of antibiotic-associated diarrhea (AAD) mice. Forty-eight Balb/c mice were randomly divided into control (Con) group, AAD Group, inulin (Inu) group, Cistanche deserticola (RCR) group, Cistanche deserticola polysaccharide (RCRDT) group and Echinacoside (Ech) group with 8 mice in each group. The diarrhea model of mice was induced by intragastric administration of lincomycin hydrochloride(3 g/kg) for 7 days, and then treated by intragastric administration of INU(5 g/kg), RCR(5 g/kg), RCRDT(200 mg/kg) and ECH (60 mg/kg),0.

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