Publications by authors named "Junwei Han"

On account of the extreme settings, stealing the black-box model without its training data is difficult in practice. On this topic, along the lines of data diversity, this paper substantially makes the following improvements based on our conference version (dubbed STDatav1, short for Surrogate Training Data). First, to mitigate the undesirable impacts of the potential mode collapse while training the generator, we propose the joint-data optimization scheme, which utilizes both the synthesized data and the proxy data to optimize the surrogate model.

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Predicting individual-level non-neuroimaging phenotypes (e.g., fluid intelligence) using brain imaging data is a fundamental goal of neuroscience.

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Oxygen evolution catalysts are critical components of proton exchange membrane water electrolysers (PEMWEs), playing a decisive role in determining both the performance and cost of these devices. Non-noble metal-based oxygen evolution catalysts have recently drawn significant attention as potential alternatives to expensive noble metal catalysts. This review systematically summarizes the mechanism of non-noble metal catalysts for the oxygen evolution reaction in acids with respect to their activity and stability, incorporating theoretical calculations and the Pourbaix diagram.

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Significant culture and ethnic diversity play an important role in shaping brain structure and function. Many attempts have been undertaken to connect ethnic variations with brain function, which, however, fluctuates over time and is costly, limiting its utility to identify consistent brain markers as well as its application to a broad population. In contrast, brain anatomy is less altered during a short period of time, but it is not fully understood whether it could serve as the ethnicity-sensitive landmark, or its variation is associated with functional one.

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Background: Single-sample pathway enrichment analysis is an effective approach for identifying cancer subtypes and pathway biomarkers, facilitating the development of precision medicine. However, the existing approaches focused on investigating the changes in gene expression levels but neglected somatic mutations, which play a crucial role in cancer development.

Findings: In this study, we proposed a novel single-sample mutation-based pathway analysis approach (ssMutPA) to infer individualized pathway activities by integrating somatic mutation data and the protein-protein interaction network.

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Carbon nanotubes (CNTs) with exceptional conductivity have been widely adopted in lithium-sulfur (Li-S) batteries. While trace metal impurities in CNTs have demonstrated electrocatalytic activity in various catalytic processes, their influence on sulfur electrocatalysis in Li-S batteries has been largely overlooked. Herein, we reveal that the trace metal impurities content in CNTs significantly improves the specific capacity and cycling performance of Li-S batteries by analyzing both our own results and previous literature with CNTs as the sulfur hosts.

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Article Synopsis
  • A new machine learning method, called SU-VAE, allows scientists to separate brain connectome data shared between humans and macaques from species-specific traits.
  • This method was validated by linking unique human features to cognitive abilities, while shared features aligned more with sensorimotor skills.
  • The results suggest that human-specific brain traits may make networks more efficient and are associated with certain genes related to axon guidance.
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Motivation: Alzheimer's disease (AD) typically progresses gradually for ages rather than suddenly. Thus, staging AD progression in different phases could aid in accurate diagnosis and treatment. In addition, identifying genetic variations that influence AD is critical to understanding the pathogenesis.

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Background: Recently, immunotherapy has been recognized as an innovative treatment with great potential for patients with colon adenocarcinoma (COAD). Although the relationships between immune cells and immune substances are intricate and still unclear, some immune cells and substances could be considered prognostic factors for predicting therapeutic efficacy. To understand the genomic signatures of COAD related to CD8 T cells that could predict the prognosis of patients receiving immunotherapy and to discover new therapeutic targets, we conducted this study.

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To enable the practical application of lithium metal batteries, it is crucial to address the challenges of dendrite growth and volume expansion in lithium metal anodes. A 3D framework offers an effective solution to regulate the lithium plating/stripping process. In this work, we present a 3D mixed ion-electron conducting (MIEC) framework as a lithium metal anode, achieved by conformally coating carbon nanotubes (CNTs) onto LiLaTiO (LLTO) particles.

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Cortical folding is closely linked to brain functions, with gyri acting more like local functional "hubs" to integrate information than sulci do. However, understanding how anatomical constraints relate to complex functions remains fragmented. One possible reason is that the relationship is estimated on brain mosaics divided by brain functions and cortical folding patterns.

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The tumor microenvironment (TME) cells interact with each other and play a pivotal role in tumor progression and treatment response. A comprehensive characterization of cell and intercellular crosstalk in the TME is essential for understanding tumor biology and developing effective therapies. However, current cell infiltration analysis methods only partially describe the TME's cellular landscape and overlook cell-cell crosstalk.

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Article Synopsis
  • - Brain imaging genetics aims to connect genetic variations with neuroimaging metrics, but traditional methods have limitations due to their dependence on individual-level data.
  • - The proposed S-GsMTLR method uses summary stats from genome-wide association studies (GWAS) to perform multivariate multi-task sparse learning, avoiding the need for raw data while improving feature selection and modeling.
  • - S-GsMTLR showed strong performance in identifying risk loci in datasets related to Alzheimer's, white matter microstructures, and whole brain imaging traits, revealing unnoticed genetic variation structures.
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Efficient recovery of rare earth elements (REEs) from wastewater is crucial for advancing resource utilization and environmental protection. Herein, a novel nitrogen-rich hydrogel adsorbent (PEI-ALG@KLN) was synthesized by modifying coated kaolinite-alginate composite hydrogels with polyethylenimine through polyelectrolyte interactions and Schiff's base reaction. Various characterizations revealed that the high selective adsorption capacity of Ho (155 mg/g) and Nd (125 mg/g) on PEI-ALG@KLN is due to a combination of REEs (Lewis acids) via coordination interactions with nitrogen-containing functional groups (Lewis bases) and electrostatic interactions; its adsorption capacity remains more than 85 % after five adsorption-desorption cycles.

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Article Synopsis
  • Researchers in AI are currently focused on creating larger and deeper neural networks, referred to as the "big model with external complexity" approach.
  • The text argues for a different approach called "small model with internal complexity," which aims to enhance neuron properties for more efficient AI models.
  • An example provided is the Hodgkin-Huxley (HH) network, which shows that a network with complex internal structures can perform similarly to a larger and simpler network like the leaky integrate-and-fire (LIF) model.
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Rechargeable sodium-chlorine (Na-Cl) batteries show high theoretical specific energy density and excellent adaptability for extreme environmental applications. However, the reported cycle life is mostly less than 500 cycles, and the understanding of battery failure mechanisms is quite limited. In this work, we demonstrate that the substantially increased voltage polarization plays a critical role in the battery failure.

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Chiral metal-organic frameworks (CMOFs) with chiral selectivity are one of the high-quality stationary phases for capillary electrochromatography (CEC). However, there is a problem of unsatisfactory enantioseparation performance of capillary columns due to insufficient loading. In this work, a lamellar CMOF (Cu-TC) was grown on the surface of the monolith in a capillary monolithic column to obtain a Cu-TC@monolithic column.

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High-grade heavy metal elements in copper slag (CS) are worth recovering. Unfortunately, the high viscosity of leaching solution, low leaching efficiency, difficult filtration and low separation efficiency of valuable components exist in the traditional sulfuric acid leaching process. In this study, the above problems are solved by sulfuric acid pretreatment + curing + water leaching.

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Previous knowledge distillation (KD) methods mostly focus on compressing network architectures, which is not thorough enough in deployment as some costs like transmission bandwidth and imaging equipment are related to the image size. Therefore, we propose Pixel Distillation that extends knowledge distillation into the input level while simultaneously breaking architecture constraints. Such a scheme can achieve flexible cost control for deployment, as it allows the system to adjust both network architecture and image quality according to the overall requirement of resources.

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Medical report generation is a valuable and challenging task, which automatically generates accurate and fluent diagnostic reports for medical images, reducing workload of radiologists and improving efficiency of disease diagnosis. Fine-grained alignment of medical images and reports facilitates the exploration of close correlations between images and texts, which is crucial for cross-modal generation. However, visual and linguistic biases caused by radiologists' writing styles make cross-modal image-text alignment difficult.

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Micro ribonucleic acids (miRNAs) play a pivotal role in governing the human transcriptome in various biological phenomena. Hence, the accumulation of miRNA expression dysregulation frequently assumes a noteworthy role in the initiation and progression of complex diseases. However, accurate identification of dysregulated miRNAs still faces challenges at the current stage.

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Background: Brain functional connectivity under the naturalistic paradigm has been shown to be better at predicting individual behaviors than other brain states, such as rest and doing tasks. Nevertheless, the state-of-the-art methods have found it difficult to achieve desirable results from movie-watching paradigm functional magnetic resonance imaging (mfMRI) -induced brain functional connectivity, especially when there are fewer datasets. Incorporating other physical measurements into the prediction method may enhance accuracy.

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The corpus callosum, historically considered primarily for homotopic connections, supports many heterotopic connections, indicating complex interhemispheric connectivity. Understanding this complexity is crucial yet challenging due to diverse cell-specific wiring patterns. Here, we utilized public AAV bulk tracing and single-neuron tracing data to delineate the anatomical connection patterns of mouse brains and conducted wide-field calcium imaging to assess functional connectivity across various brain states in male mice.

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Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology important for understanding brain function and species evolution.

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