RUNX1-induced upregulation of PTGS2 enhances cell growth, migration and invasion in colorectal cancer cells.

Colorectal cancer (CRC) arises via the progressive accumulation of dysregulation in key genes including oncogenes and tumor-suppressor genes. Prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) acts as an oncogenic driver in CRC. Here, we explored the upstream transcription factors (TFs) responsible for elevating PTGS2 expression in CRC cells.

3D-Printed Liquid Metal-in-Hydrogel Solar Evaporator: Merging Spectrum-Manipulated Micro-Nano Architecture and Surface Engineering for Solar Desalination.

Solar desalination driven by interfacial heating is considered a promising technique to alleviate the freshwater shortage crisis. However, its further extension and application are confined by factors such as highlighted salt accumulation, inferior energy efficiency, and poor durability. Herein, a microsized eutectic gallium-indium (EGaIn) core-shell nanodroplet (denoted as LMTE) with photo-cross-linking and photothermal traits, stabilized by allyl glycidyl ether (AGE)-grafting tannic acid (TA), is explored as the solar absorber for broadband light absorbing and localized micro-nano heat channeling.

Synergistic Dual-Mechanism Localized Heat Channeling and Spectrum-Tailored Liquid Metal Hydrogels for Efficient Solar Water Evaporation and Desalination.

Photothermal hydrogels featuring broadband light absorption abilities and highly hydrated networks provide an appealing mass-energy transfer platform for water evaporation by using solar energy. However, the targeted delivery of solar heat energy to power the water evaporation process remains challenging. Herein, enlightened by metal-phenolic coordination chemistry and camouflaged architecture, photothermal hydrogels with dual-mechanism vaporization structure are tactfully designed via a rational interfacial engineering and integration strategy to enable near-µm heat confinement and highly efficient light-to-heat conversion ability.

Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.

Long non-coding RNAs (lncRNAs) have been revealed to harbor open reading frames (ORFs) that can be translated into small peptides. The peptides may participate in the pathogenesis of colorectal cancer (CRC). Herein, we investigated the role of a lncRNA BVES-AS1-encoded peptide in colorectal tumorigenesis.

Non-invasive measurement of tumor immune microenvironment and prediction of survival and chemotherapeutic benefits from F fluorodeoxyglucose PET/CT images in gastric cancer.

Background: The tumor immune microenvironment could provide prognostic and predictive information. It is necessary to develop a noninvasive radiomics-based biomarker of a previously validated tumor immune microenvironment signature of gastric cancer (GC) with immunohistochemistry staining.

Methods: A total of 230 patients (training (n = 153) or validation (n = 77) cohort) with gastric cancer were subjected to (Positron Emission Tomography-Computed Tomography) radiomics feature extraction (80 features).

Integrating Dual-Interfacial Liquid Metal Based Nanodroplet Architectures and Micro-Nanostructured Engineering for High Efficiency Solar Energy Harvesting.

Broadband strong absorption of solar light over a wide range of angles, low heat loss, and excellent structural reliability are of significance for enhancing solar harvesting of photothermal materials; however, it remains a challenge to achieve these attributes simultaneously. Herein, a tailored photothermal composite nanodroplet (LMP-rGO) featured with dual-interface, which comprises liquid metal (LM) core with polydopamine (PDA) photothermal middle layer of tunable thickness and reduced graphene oxide (rGO) shell, is particularly prepared. Thermal-insulating PDA coating and light-absorbing carbonaceous shell allow it to synergistically suppress heat loss and reinforce photon absorptivity.

Indirect comparison between powered and manual circular staplers for left-sided colorectal anastomoses: clinical and economic outcomes in China.

Aims: This study aimed to examine the economic and clinical benefits of a new powered circular stapler for left-sided colorectal construction in China.

Methods: A decision analysis model was constructed for a cohort of adult patients who underwent left-sided colorectal anastomoses, using either the Echelon Circular Powered (ECP) stapler) or the conventional manual circular staplers (MCS). The complications rates and healthcare resource utilization in the ECP cohort were obtained from the single-arm ECP trial (NCT03326895).

Sphingolipid metabolism plays a key role in diabetic peripheral neuropathy.

Introduction: As the most common chronic complication of diabetes mellitus (DM), diabetic peripheral neuropathy (DPN) seriously affects the quality of life of DM patients. So, it is of great significance for the diagnosis and treatment of DPN. In recent years, there have been numerous studies on pathogenesis and biomarkers of DM, but there are few studies on the biomarkers of DPN.

Intratumoral and Peritumoral Radiomics of Contrast-Enhanced CT for Prediction of Disease-Free Survival and Chemotherapy Response in Stage II/III Gastric Cancer.

Background: We evaluated the ability of radiomics based on intratumoral and peritumoral regions on preoperative gastric cancer (GC) contrast-enhanced CT imaging to predict disease-free survival (DFS) and chemotherapy response in stage II/III GC.

Methods: This study enrolled of 739 consecutive stage II/III GC patients. Within the intratumoral and peritumoral regions of CT images, 584 total radiomic features were computed at the portal venous-phase.