AI-driven design of customized 3D-printed multi-layer capsules with controlled drug release profiles for personalized medicine.

Personalized medicine aims to effectively and efficiently provide customized drugs that cater to diverse populations, which is a significant yet challenging task. Recently, the integration of artificial intelligence (AI) and three-dimensional (3D) printing technology has transformed the medical field, and was expected to facilitate the efficient design and development of customized drugs through the synergy of their respective advantages. In this study, we present an innovative method that combines AI and 3D printing technology to design and fabricate customized capsules.

Real-time fluorescence imaging of telomerase and miR378 in living cells using a two-color DNA tetrahedron nanoprobe combined with molecular beacons.

A biosensor that can detect biomarkers accurately, quickly, and conveniently is important for the diagnosis of various diseases. However, most of the existing detection methods require sample extraction, which makes it difficult to detect and image intracellular molecules or to detect two different types of biomarkers simultaneously. In this study, we constructed a DNA tetrahedral nanoprobe (DTP) capable of detecting both miR378 and telomerase, both of which are tumor markers.

A radical photochromic metal-organic framework for boosting NIR-II photothermal conversion and therapy.

This work demonstrates for the first time that a photochromic metal organic framework (pMOF) can be employed as a promising class of NIR-II photothermal material based on the photoinduced donor-acceptor intermolecular charge transfer process. After further surface-modification, such UV-activated pMOF-a nanoparticles allow the strong inhibition of 4T1 cancer cells under 1064 nm laser irradiation.

Establishment of primary health information in the COVID-19 outbreak: A cross-sectional study of population awareness of self-testing.

The global pandemic of the Corona Virus Disease 2019 is a severe threat to human health. This paper aims to investigate the status of mass health self-examination awareness and its influencing factors during the COVID-19 epidemic and establish complete health information to intervene in the prevention and control of the COVID-19 epidemic. The study used a simple random sampling method to survey permanent residents (9761 people) aged 15-70 years in a region of Jiangsu Province, China.

Titanium dioxide hierarchical microspheres decorated with atomically dispersed platinum as an efficient photocatalyst for hydrogen evolution.

Micromorphology engineering and co-catalyst construction are considered as feasible approaches to boost the photocatalytic hydrogen evolution performance. Herein, we combined two approaches to construct a new photocatalyst with titanium dioxide (TiO) hierarchical microspheres (HMSs) as support and atomically dispersed platinum (Pt) species as co-catalyst (donated as TiO HMSs@xPt). The as-prepared TiO HMSs@xPt photocatalysts exhibited combined advantages including adequate light harvesting, improved charge-carrier separation and transport, abundant active sites, and reduced Pt consumption, which are favorable for photocatalytic hydrogen evolution.

Immobilization of Cr(VI) from solution by a graphene oxide-nZVI/biochar composite.

A graphene oxide (GO)-nanoscale zerovalent iron (nZVI)-biochar composite (GO-nZVI/BC) was synthesized prior to characterization by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy analyses. Batch experiments were performed at different initial Cr(VI) concentrations, contact times, and solution pH values. The effects of coexisting anions and chelating agents were also examined.

Biochars with excellent Pb(II) adsorption property produced from fresh and dehydrated banana peels via hydrothermal carbonization.

Fresh and dehydrated banana peels were used as biomass feedstock to produce highly effective sorbent biochars through a facile one-step hydrothermal carbonization approach with 20%vol phosphoric acid as the reaction medium. The elemental ratio of oxygen content of the two as-prepared biochars were about 20%, and the FT-IR analysis confirmed the existence of abundant surface functional groups such as hydroxyl and carboxyl which greatly enhanced the adsorption performance. The sorbents showed excellent lead clarification capability of 359mg·g and 193mg·g for dehydrated and fresh banana peels based biochars, respectively.

Oxide nanowires for solar cell applications.

Oxide nanowire arrays were studied for their applications to solar cells. It was demonstrated that the nanowires could provide direct pathways for electron transport in dye-sensitized solar cells and therefore, while forming photoelectrode films, they offered better suppression of charge recombination than nanoparticles. However, the photoelectron films consisting of nanowires suffered a disadvantage in giving large surface area for dye adsorption.