Blocking long noncoding RNA MALAT1 restrained the development of laryngeal and hypopharyngeal carcinoma.

Purpose: The long non-coding RNA MALAT1 is a predictive marker in several solid tumors with highly conserved sequences. However, the role of non-coding RNA in development of laryngeal or hypopharyngeal cancer remains unclear.

Methods: Tumor tissues and adjacent non-cancer tissues of 24 patients were collected.

The inhibition of tumor protein p53 by microRNA-151a-3p induced cell proliferation, migration and invasion in nasopharyngeal carcinoma.

A close relation between microRNA-151a-3p (miR-151a-3p) and nasopharyngeal carcinoma (NPC) has been reported, however, the molecular mechanism is still unclear. The aim of the present study was to explore the mechanism in the promotion of miR-151a-3p to NPC progression. The levels of miR-151-3p in several NPC cell lines were detected in order to screen an experimental cell line.

Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects.

Olfactory ensheathing cells from the olfactory bulb and olfactory mucosa have been found to increase axonal sprouting and pathfinding and promote the recovery of vibrissae motor performance in facial nerve transection injured rats. However, it is not yet clear whether olfactory ensheathing cells promote the reparation of facial nerve defects in rats. In this study, a collagen sponge and silicone tube neural conduit was implanted into the 6-mm defect of the buccal branch of the facial nerve in adult rats.

Pectolinarigenin Suppresses the Tumor Growth in Nasopharyngeal Carcinoma.

Background/aims: Nasopharyngeal cancer (NPC) is one of the common human malignant diseases all over the world, and chemotherapy remains the main therapy for NPC. However, the survival and life quality of NPC patients are still very poor. Thus, novel and selective anti-tumor agents are pressingly needed.

[The cultivation and migration in vitro of olfactory ensheathing cells from human olfactory mucosa].

Objective: To investigate the bionomics of the olfactory ensheathing cells (OECs) of human olfactory mucosa.

Method: To separate and cultivate the OECs of human and rat olfactory mucosa. To observe the cell growth, cell grouping and cell migration in vitro of the two types of OECs.

MDA-7/IL-24 inhibits cell survival by inducing apoptosis in nasopharyngeal carcinoma.

Aims: Nasopharyngeal carcinoma (NPC) is the most common primary malignancy of the nasopharynx. Due to its local recurrence and distant metastasis, conventional therapy is usually ineffective. MDA-7/IL-24 (melanoma differentiation associated gene 7), a member of the IL10 family of cytokines, inhibits growth of various human cancer cells, but the underlying mechanism is largely unknown.

Measuring the extent of total thyroidectomy for differentiated thyroid carcinoma using radioactive iodine imaging: relationship with serum thyroglobulin and clinical outcomes.

IMPORTANCE Despite performing total thyroidectomy (TT), postoperative radioactive iodine (RAI) imaging often demonstrates the presence of residual thyroid tissue within the operative bed. OBJECTIVE To measure the extent of TT using postoperative RAI imaging and assessing serum thyroglobulin (Tg) level for patients with differentiated thyroid carcinoma (DTC). DESIGN, SETTING, AND PARTICIPANTS We evaluated 245 patients undergoing TT for clinically staged cT1-3N0M0 DTC, who underwent diagnostic postoperative RAI imaging.

MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies.

Background: O(6)-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent.

Silencing of HEPN1 is responsible for the aggressive biological behavior of pituitary somatotroph adenomas.

Background/aims: The pathogenic mechanisms underlying pituitary adenoma formation, progression, and invasion are poorly understood. To identify candidate tumor suppressor genes, we selected somatotroph adenomas as representative of pituitary adenomas.

Methods/results: We used genome-wide differential expression analysis in 15 invasive and 12 noninvasive somatotroph adenomas.

Association between MMP1 -1607 1G>2G polymorphism and head and neck cancer risk: a meta-analysis.

Background: MMP1 is an important member of the MMP endopeptidase family that plays a critical role in the development of head and neck cancer (HNC). Several studies have investigated the association between the MMP1 -1607 1G>2G polymorphism and risk of HNC, but their results have been inconsistent. Here, we conducted a meta-analysis to further explore the role of the MMP1 -1607 1G>2G polymorphism in HNC development.

Association of GSTP1 Ile105Val polymorphism and risk of head and neck cancers: a meta-analysis of 28 case-control studies.

Background And Aims: The Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent. The aim of this study was to evaluate the possible association between the GSTP1 Ile105Val polymorphism and risk of HNC.

Method: We performed a search in the relevant electronic database and a meta-analysis based on 28 published case-control studies that included 6,404 cases and 6,523 controls.

3D body segment oscillation and gait analysis for vestibular disorders.

Objective: To investigate the patterns of gait and locomotion in three dimension space in patients with vestibular disorders.

Methods: A 3D motion analysis system was employed to evaluate locomotor pattern and body's oscillation during gait under different conditions (normal, slow, fast speeds walking with eye open and normal speed walking with eyes closed) of nine patients with vestibular disorders. Twenty-one markers placed on the subject to record kinematics and locomotions of the head, spine and pelvis segments while walking.

[OSAHS patient gas up-take cross-sectional area nasopharynx sound reflection examination and significance].

Objective: To explore a simple and accurate method for localization of upper airway obstruction in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and provide instructions for surgical treatment.

Method: Fifty OSAHS patients confirmed by PSG underwent acoustic rhinometric and pharyngometric assessment by Eccovision. The parameters were recorded, including nasal minimal cross-sectional area (NMCA), distance of MCA from the nostril (DCAN), minimum cross-sectional area at the nasal valve(MCA), nasal resistance (NR) and nasal volume from 0 to 6 cm from the nostril (NCV), as well as pharyngeal cross-sectional area (CSA) and volume from 4.

[MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis].

Objective: To investigate the level of mRNA expression of complement C3 and C4 in rat nasal mucosa and to reveal the relationship with the pathogenesis of allergic rhinitis (AR) .

Methods: Twenty healthy SD rats were randomly divided into AR group and control group, 10 rats for each group. Ten rats was sensitized and intranasally challenged by ovalbumin and Al (OH)3 (as supplement) as allergic rhinitis models, and the control group was treated by saline.

Sweat duct carcinoma of lip with multiple cervical lymph nodes metastasis.

Sclerosing sweat duct carcinoma (SSDC) is a rare cutaneous neoplasm. A 28-year-old man presented with 2-3 years history of a tetter on his upper lip, and a 3 cm x 4 cm lymph node was palpable in the left submandibular area. MRI showed a mass in the upper lip extending into the buccal mucosa and orbicular muscle, and multiple cervical lymph nodes metastasis on both sides was suspected.

[Imaging analysis of the ethmoid roof].

Objective: To discuss the image anatomy characters in the height and contour of the ethmoid roof.

Method: Retrospective review of direct coronal sinus computed tomography (CT) scans in 160 patients. The height and contour of the fovea ethmoidalis, and the connection modes between ethmoidal roof and cribriform plate were examined.

[Assessment of acoustic rhinometry in examining nasal ventilation function].

Objective: To evaluate the use of acoustic rhinometry (AR) in determination of nasal ventilation function in patients complaining of nasal obstruction, and to discuss the selection of parameters.

Method: Acoustic rhinometry was measured in 36 patients complaining of nasal obstruction with nasal diseases and 20 adults without nasal obstruction as control, the parameters including mean nasal cross-sectional area (MNCA), minimal cross-sectional area (MCA), volume of nasal cavity (NV) and nasal resistance (NR).

Result: There is no sex difference for MNCA, MCA, NV and NR measured in control group (P > 0.

[Acoustic rhinometry measurement from the patients with deviation of nasal septum].

Objective: Investigating the acoustic rhinometry parameter values from the patients with deviation of nasal septum.

Method: Testing 60 cases with deviation of nasal septum by means of Eccovision acoustic rhinometry, recording and statistics analysing nasal minimal cross sectional area (NMCA), nasal cavity value (NCV), distance of minimal cross section area from the nostril (DCAN) and nasal resistance (NR).

Result: NMCA: (0.

[Sorbalgon used in functional endoscopic sinus surgery].

Objective: To select an effective nasal cavity packing hemostasia material in functional endoscopic sinus surgery.

Method: The hemostasia effect and nasal cavity response between vaseline gauze strip and Sorbalgon was compared after FESS.

Result: There was a good hemostasia result when using Sorbalgon to pack the nasal cavity in FESS.