Publications by authors named "Junsong Wang"

Sepsis remains a life-threatening condition with high mortality rates despite current therapeutic approaches. While Huang-Lian-Jie-Du Decoction (HLJDD), a traditional Chinese medicine formula, has been historically used to treat inflammatory conditions, its therapeutic potential in sepsis and underlying mechanisms remain unexplored. This study investigated HLJDD's comprehensive effects on sepsis pathophysiology using a rat cecal ligation and puncture (CLP) model.

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  • The study aimed to evaluate how the systemic immune-inflammation index (SII) relates to the risk of dying within two years in older patients who suffered hip fractures.
  • A cohort of hip fracture patients aged 65 and older was analyzed, with SII calculated from blood tests, and patients were divided into three groups based on their SII scores.
  • Findings showed that higher SII levels correlated with increased mortality risk, indicating that SII could help identify older patients who are at a higher risk of death following hip fracture surgery.
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SSVEP-based brain-computer interface (BCI) systems have received a lot of attention due to their relatively high Signal to Noise Ratio (SNR) and less training requirements. Most of the existing steady-state visual evoked potential (SSVEP) detection algorithms treat the prior probability of each alternative target being selected as equal. In this study, the prior probability distribution of alternative targets was introduced into the SSVEP recognition algorithm, and an asynchronous training-free SSVEP-BCI detection algorithm for non-equal prior probability scenarios was proposed.

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The current study aims to identify potential metabolic biomarkers that predict the progression to prediabetes in women with a history of gestational diabetes mellitus (GDM). We constructed a prediabetes group ( = 42) and a control group ( = 40) based on a2-hour 75 g oral glucose tolerance test for women with a history of GDM from six weeks to six months postpartum, and collected their clinical data and biochemical test results. We performed the plasma metabolomics analysis of the subjects at the fasting and 2-hour post-load time points by using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).

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has long been used in traditional Tibetan medicine to treat various inflammatory and pain-related conditions. However, blue-flowered () is becoming increasingly scarce due to overharvesting. As a potential alternative, yellow-flowered () shows promise but requires comprehensive characterization.

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  • Cucurbitacin B (CuB) is a natural compound known for its strong anticancer effects, but its effectiveness is limited due to poor absorption in the body when taken orally.
  • Researchers studied how CuB is metabolized in rats after oral administration, identifying 13 metabolites, with one key variant, CuB-Cys, showing similar anti-cancer activity as CuB but with less toxicity toward normal cells.
  • The study sheds light on CuB's metabolic pathways and suggests that using its metabolites, like CuB-Cys, could enhance its therapeutic effects while minimizing side effects in cancer treatment.
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Aging is one of the most significant factors affecting cardiovascular health, with cellular senescence being a central hallmark. Senescent cells (SCs) secrete a specific set of signaling molecules known as the senescence-associated secretory phenotype (SASP). The SASP has a remarkable impact on age-associated diseases, particularly cardiovascular diseases (CVD).

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Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine (TCM) including the herb pair of Zhiqiao-Danggui (ZD) offers a multifaceted treatment approach through promoting blood circulation, yet its specific anti-ischemic mechanism remains unclear. This study used the photochemically induced thrombosis (PIT) mouse model and the oxygen glucose deprivation/reoxygenation (OGD/R) cell model to explore the therapeutic effect of ZD on ischemic stroke.

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  • Researchers developed a system using an optical microscope and electromagnet to study how magneto-controlling micro-nano materials like micro-nano graphite flakes (MGFs) move without contact.
  • They identified that the product of the magnetic field's intensity and gradient is the main driving force for the motion, and the direction of movement is influenced by the vector direction of the magnetic field.
  • A dynamic model was created to predict the flipping dynamics of MGFs, revealing additional phenomena like delay effects and fatigue due to gas adsorption, which can enhance the control of materials' macrostructure and functions.
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Ischemic stroke, accounting for 80 % of all strokes, is a major cause of morbidity and mortality worldwide. However, effective and safe pharmacotherapy options for ischemic injury are limited. This study investigated the therapeutic effects of wogonoside, a compound derived from Radix Scutellariae, on ischemia/reperfusion (I/R) injury.

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Objective: Structural support for depressed tibial plateau fractures is receiving increasing attention. Currently, there has been little biomechanical evaluation of structural support. This work aimed to investigate the effect of structural support size and position on fracture fixation stability.

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Thunb. (PMT) has shown promise in exerting cerebrovascular protective effects, and its potential for treating ischemic stroke (IS) has garnered attention. However, the lack of clarity regarding its chemical constituents and mechanisms has significantly hindered its clinical application.

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Previous studies have successfully applied a lightweight recurrent neural network (RNN) called Echo State Network (ESN) for EEG-based emotion recognition. These studies use intrinsic plasticity (IP) and synaptic plasticity (SP) to tune the hidden reservoir layer of ESN, yet they require extra training procedures and are often computationally complex. Recent neuroscientific research reveals that the brain is modular, consisting of internally dense and externally sparse subnetworks.

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The pericarp of (HPP) has traditionally been used for treating jaundice and hepatitis. However, the specific hepatoprotective components and their safety/efficacy profiles remain unclear. This study aimed to characterize the total cucurbitacins (TCs) extracted from HPP and evaluate their hepatoprotective potential.

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  • 4-octyl itaconate (4-OI) is a derivative known for its anti-inflammatory and antioxidant properties, and this study explores its potential to protect the liver from oxidative stress-related injuries.
  • The research demonstrated that 4-OI reduced cytotoxicity and oxidative stress in liver cells and activated key signaling pathways (PI3K/AKT/mTOR and MAPK) that play a role in its protective effects.
  • In mouse models, 4-OI decreased liver damage from acetaminophen and increased the expression of protective proteins, indicating that its antioxidant effects are linked to the activation of the Nrf2/Sirt3 pathway through phosphorylation of AKT and ERK1/2.
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Trichlorfon, one of the most widely used organophosphate insecticides, is commonly employed in aquaculture and agriculture to combat parasitic infestations. However, its inherent instability leads to rapid decomposition into dichlorvos (DDVP), increasing its toxicity by eightfold. Therefore, the environmental effects of trichlorfon in real-world scenarios involve the combined effects of trichlorfon and its degradation product, DDVP.

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  • * The structures of the new compounds were determined using detailed spectroscopic analysis and TD-DFT-based ECD calculations.
  • * In vitro testing revealed that several isolated compounds exhibited significant anti-inflammatory activity, particularly one compound that demonstrated the strongest effect with an IC value of 426.2 nM against nitric oxide production in activated microglia cells.
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Aldose reductase (AR) is an important enzyme involved in the reduction of various aldehyde and carbonyl compounds, including the highly reactive and toxic 4-hydroxynonenal (4-HNE), which has been linked to the progression of various pathologies such as atherosclerosis, hyperglycemia, inflammation, and tumors. AR inhibitors have potential therapeutic benefits for these diseases by reducing lipid peroxidation and mitigating the harmful effects of reactive aldehydes. In this study, we found that torachrysone-8-O-β-d-glucoside (TG), a natural product isolated from Polygonum multiflorum Thunb.

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Excessive melanogenesis leads to hyperpigmentation, which is one of the common skin conditions in humans. Existing whitening cosmetics cannot meet market needs due to their inherent limitations. Thus, the development of novel skin-whitening agents continues to be a challenge.

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Sepsis arises from an uncontrolled inflammatory response to infection that can lead to organ failure. The gut microbiome is increasingly recognized as a key modulator of sepsis progression. This study investigated whether Coptis chinensis water extract (CCWE) could attenuate sepsis by modulating the gut microbiome and immune response.

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Root damage from urban street trees represents a substantial concern arising from the conflict between root growth and limited growth spaces. Nonetheless, the phenomenon of root damage, which threatens the safety of urban facilities, appears to have received little scholarly attention. Moreover, the effectiveness of some proposed measures for root damage prevention and control has not yet received consistent evaluation.

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Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disease, and an imbalance in the gut microbiota is a critical factor in its development. Gastrodia elata (G. elata), an Orchidaceae plant, is recognized for its nutritional and medicinal value.

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