Publications by authors named "Junshu Xue"
Pullorum disease (PD) is a bacterial infection caused by () that affects poultry. It is highly infectious and often fatal. Antibiotics are currently the mainstay of prophylactic and therapeutic treatments for PD, but their use can lead to the development of resistance in pathogenic bacteria and disruption of the host's intestinal flora.
View Article and Find Full Text PDFLead and cadmium are foodborne contaminants that threaten human and animal health. It is well known that lead and cadmium produce hepatotoxicity; however, defense mechanisms against the co-toxic effects of lead and cadmium remain unknown. We investigated the mechanism of autophagy (defense mechanism) against the co-induced toxicity of lead and cadmium in rat hepatocytes (BRL-3A cells).
View Article and Find Full Text PDFArticle Synopsis
- The inflammatory response is linked to diseases like atherosclerosis and ulcerative colitis, and inhibiting it is essential for treatment.
- Berberine hydrochloride (BBR) is a natural anti-inflammatory agent but has serious side effects due to its distribution in the body, and targeted delivery systems are currently lacking.
- A new delivery system using low molecular weight fucoidan combined with PEGylated liposomes effectively targets inflamed vascular endothelial cells, improving BBR's efficacy while reducing toxicity to main organs.
Background: Pseudorabies virus (PRV) infections in susceptible non-porcine species trigger uncontrolled inflammations and eventually fatal encephalitis. Resveratrol (Res) has broad pharmacological functions including anti-virus, anti-inflammation, and neuroprotective.
Purpose: We attempted to investigate the potential of Res in ameliorating PRV infection pathology in mice and decipher the mechanism of Res in treating PRV.