Publications by authors named "Junshu Guo"
Article Synopsis
- Photosynthetic bacteria (PSB) and their outer membrane vesicles (OMVs) present promising drug delivery systems due to their photothermal capabilities and antioxidant properties, but face challenges like size and immunogenicity.
- Bacteria-derived nanovesicles (BNVs), created through controlled extrusion, offer solutions to OMVs' issues such as low yield and inconsistent sizes, containing higher concentrations of beneficial metabolites like lysophosphatidylcholine (LPC).
- The study shows that while BNVs enhance wound healing by promoting cell proliferation and migration through the EGFR/AKT/PI3K pathway, OMVs excel in anti-cancer properties, particularly in activating macrophages toward an M1 phenotype.
Boron neutron capture therapy (BNCT) is a promising therapy for malignant tumors that requires selective and high concentrations of B accumulation in tumor cells. Despite ongoing developments in novel boron agents and delivery carriers, the progress and clinical application of BNCT is still restricted by the low B accumulation and tumor-to-normal tissue (T/N) ratio. Herein, a dissolving microneedle-based transdermal drug delivery system was specifically designed for BNCT in a mouse model of melanoma.
View Article and Find Full Text PDF