Benchtop and different miniaturized near-infrared spectrometers application study: Calibration transfer and 2D-COS for in-situ analysis of moisture content in HPMC.

The demand for miniaturized near-infrared (NIR) spectrometers has surged due to their potential for in-situ analysis. However, their predictive accuracy has not yet matched that of traditional benchtop instruments. This study evaluates the effectiveness of rapid quantitative moisture analysis in hydroxypropyl methylcellulose (HPMC) using a benchtop spectrometer, Antaris II from Thermo Fisher Scientific Inc.