Efficacy and tolerability of combined medication of two different antimuscarinics for treatment of adults with idiopathic overactive bladder in whom a single agent antimuscarinic therapy failed.

Objective: Recent studies have investigated a combination of two antimuscarinics for adult neurogenic bladder managed with clean intermittent catheterization or pediatric refractory overactive bladder (OAB). We assessed the efficacy and tolerability of this strategy in adults with idiopathic OAB.

Methods: We reviewed 49 patients with idiopathic OAB who received combined antimuscarinic medication.

Detrusor after-contraction is associated with bladder outlet obstruction.

Aims: The aims of this study were to determine how we can differentiate detrusor after-contraction (DAC) from artifacts, and to understand the clinical implications and significance of DAC.

Materials And Methods: A retrospective analysis was performed on 2,309 patients with neurogenic or non-neurogenic voiding dysfunction. Investigators asked patients to cough when detrusor contraction occurred following cessation of urinary flow.

Predictor of de novo urinary incontinence following holmium laser enucleation of the prostate.

Aims: To investigate the incidence of de novo urinary incontinence (UI) after holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia and to determine predictors of postoperative de novo UI.

Methods: A total of 204 men who underwent HoLEP and in whom 12-month follow-up data on UI were available were included in this study. The efficacy of HoLEP was assessed at 1-, 3-, 6-, and 12-month postoperatively using the International Prostate Symptom Score (IPSS) and with uroflowmetry.

Early recovery of urinary continence after radical prostatectomy: correlation with vesico-urethral anastomosis location in the pelvic cavity measured by postoperative cystography.

Objectives: To determine the association of vesico-urethral anastomosis location (VUAL) with early recovery of urinary continence (UC) after radical prostatectomy (RP).

Methods: A retrospective analysis of 678 patients who underwent RP was carried out. Patients were divided into three groups based on the VUAL as determined by postoperative cystography: group I - VUAL above the upper margin of the symphysis pubis (SP), group II - between the upper margin and the middle of the SP, and group III - below the middle of the SP.

Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy.

Objectives: To identify the prognostic significance of lymphovascular invasion (LVI) and perineural invasion (PNI) in patients undergoing radical prostatectomy for prostate cancer.

Methods: Overall, 237 patients who had undergone radical prostatectomy for prostate cancer between 1995 and 2004 were analyzed for all clinical and pathological factors. The influence of these two pathological features on biochemical failure-free survival was evaluated by univariate and multivariate analysis.

The clinical significance of poor bladder compliance.

Aims: There is limited data on bladder compliance associated with lower urinary tract dysfunction. The aim of this study was to investigate the decrease in bladder compliance, and the clinical relationship between patterns of increased pressure with neurological disease.

Materials And Methods: A retrospective analysis was performed in 5,027 patients with voiding dysfunction between June 2002 and April 2008.