Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus SCNU-F0006.

One previously undescribed alkaloid, named penifuranone A (), and three known compounds (-) were isolated from the mangrove endophytic fungus SCNU-F0006. The structure of the new alkaloid () was elucidated based on extensive spectroscopic data analysis and single-crystal X-ray diffraction analysis. Four natural isolates and one new synthetic derivative of penifuranone A, compound , were screened for their antimicrobial, antioxidant, and anti-inflammatory activities.

The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults.

Diabetes is a common chronic metabolic disease with complex causes and pathogenesis. As an immunomodulator, vitamin D has recently become a research hotspot in the occurrence and development of diabetes and its complications. Many studies have shown that vitamin D can reduce the occurrence of diabetes and delay the progression of diabetes complications, and vitamin D can reduce oxidative stress, inhibit iron apoptosis, promote Ca influx, promote insulin secretion, and reduce insulin resistance.

Design, synthesis, and biological evaluation of a series of new anthraquinone derivatives as anti-ZIKV agents.

The major severe complications linked to Zika virus (ZIKV) cause the global public health problems, including microcephaly and other congenital abnormalities in newborns, and Guillain-Barré syndrome, meningoencephalitis, multi-organ failure in adults. However, neither approved vaccines nor drugs are available for ZIKV. In this study, we describe the design, synthesis and the anti-ZIKV activities of a series of anthraquinone analogs.

A new chromone from endophytic fungus sp. ZJ-68.

One chromone (), together with four known alkaloids, were isolated from the mangrove endophytic fungus sp. ZJ-68. Their structures were elucidated by a combination of HRESIMS and NMR spectroscopic analyses.

Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility.

This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized multifactor dimensionality reduction (GMDR) combined with the logistic regression model. T2DM patient-control haplotype was analyzed in silico using the haplotype analysis algorithm SHEsis.