Publications by authors named "Junrong Diao"
Purpose: To investigate the follicle microenvironments of women with premature ovarian insufficiency (POI), with normal ovarian reserve function, and who are older (age >40 years) and to identify potential therapeutic targets.
Patients And Methods: In total, 9 women who underwent in vitro fertilization(IVF) or intracytoplasmic sperm injection(ICSI) were included in this study. The first punctured follicle of each patient was used.
Article Synopsis
- The study aimed to explore the follicle microenvironment in women with premature ovarian insufficiency (POI), normal ovarian reserve, and advanced maternal age (AMA) to find potential treatment targets.
- Researchers analyzed 9 women undergoing fertility treatments using single-cell RNA sequencing, identifying various cell types within the follicles, which included different immune cells and granulosa cells.
- Results showed increased granulosa cells and decreased gamma delta T cells in POI and AMA patients, with a loss of VEGFA-FLT1 interaction linked to inflammation, suggesting that targeting this interaction could help treat POI and age-related fertility issues.
Background: Coronavirus disease 2019 (COVID-19) has raised concerns about its potential effects on human fertility, particularly among individuals undergoing assisted reproductive therapy (ART). However, the impact of COVID-19 on female reproductive and assisted reproductive outcomes is unclear. In this study, we aimed to evaluate the effects of COVID-19 on pregnancy outcomes during frozen-thawed embryo transfer (FET) cycles.
View Article and Find Full Text PDFBackground: Menstrual cycle length (MCL) and ovarian response varies widely among women of childbearing age. They are provided with anti-Mu¨llerian hormone (AMH) cutoffs for "normal" and "weakened" ovarian responses, which give an early warning of the onset of decreased ovarian response.
Methods: This was a retrospective study in women aged 21 to 35 years with MCLs of 21-35 days receiving in vitro fertilization (IVF) treatment at Center for Reproductive Medicine from October 2018 to October 2021.
Background: Caesarean section rates are rising worldwide. One adverse effect of caesarean section reported in some studies is an increased risk of subfertility. Only a few studies have assessed the relationship between the previous mode of delivery and in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) reproductive outcomes.
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