Publications by authors named "Junqin Zhu"
Article Synopsis
- Collective migration of epithelial tissues is vital for developmental processes and maintaining tissue structure, requiring precise coordination of motion influenced by the substrate's mechanical properties.
- The study finds that epithelial monolayers migrate faster on viscoelastic substrates with slower stress relaxation, leading to less deformation and enhanced fluidity.
- Conversely, on faster-relaxing substrates, monolayers face more resistance, resulting in slower migration and limited cell movement, highlighting the importance of substrate characteristics in cell dynamics.
A self-corrosion microelectrolysis (SME)-enhanced membrane-aerated biofilm reactor (eMABR) was developed for the removal of pollutants and reduction of antibiotic resistance genes (ARGs). Fe and Fe formed iron oxides on the biofilm, which enhanced the adsorption and redox process. SME can induce microorganisms to secrete more extracellular proteins and up-regulate the expression of ammonia monooxygenase (AMO) (0.
View Article and Find Full Text PDFMethylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific loci was shown to be sufficient to silence synthetic and endogenous gene expression through this mechanism. A critical parameter for DNA methylation-based silencing is the distribution of CpGs within the target promoter.
View Article and Find Full Text PDFMethylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific loci was shown to be sufficient to silence synthetic and endogenous gene expression through this mechanism. A critical parameter for DNA methylation-based silencing is the distribution of CpGs within the target promoter.
View Article and Find Full Text PDFArticle Synopsis
- Circulating monocytes can differentiate into macrophages in tumors and need to migrate through a dense collagen-rich environment to do so.
- Research shows that increased stiffness and faster stress relaxation of the surrounding matrix enhance monocyte migration.
- Monocyte migration relies on actin polymerization at the leading edge rather than matrix adhesions, allowing them to create paths through the viscous matrices.
In multicellular organisms, cells actively sense and control their own population density. Synthetic mammalian quorum-sensing circuits could provide insight into principles of population control and extend cell therapies. However, a key challenge is reducing their inherent sensitivity to "cheater" mutations that evade control.
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