Spatiotemporal distribution, environmental correlation and health risk analysis of (Diptera: Culicidae) in Beijing, China.

The Giles, 1901 (Diptera: Culicidae) is major vector of Japanese encephalitis (JE) in China, and this study aimed to uncover the vector's spatiotemporal distribution and environmental correlation in Beijing. In study area, the Remote Sensing (RS), Global Position System (GPS), and Geographic Information System (GPS) were used to clarify the distribution characteristics of vector on spatial and temporal scales, and regressions analysis of cross-sectional study was performed to detect the environmental factors linked with the density and presence of . In study area, the scenic area was the major environmental area for breeding of the vector, August was the primary peak month, the new urban development area (NUDA) was major distribution subarea of Beijing, and the vector could be detected throughout the subarea of Beijing from June to September.

Raw and Wine Processed Schisandra chinensis Regulate NREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by Modulating HPA Axis.

Clinical studies have shown that insomnia and anxiety are usually accompanied by cardiovascular dysfunction. In traditional Chinese medicine, (SC) and wine processed (WSC) are mainly used for the treatment of dysphoria, palpitation and insomnia. However, little attention was paid to its mechanism.

Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents.

A ligand-based and docking-based virtual screening was carried out to identify novel MDM2 inhibitors. A pharmacophore model with four features was used for virtual screening, followed by molecular docking. Seventeen compounds were selected for an MDM2 inhibition assay, and compounds AO-476/43250177, AG-690/37072075, AK-968/15254441, AO-022/43452814, and AF-399/25108021 showed promising MDM2 inhibition activities with values of 9.

Structural Tunability on Naphthalimide-Based Dendrimer Gelators via Glaser Coupling Interaction with Tailored Gelation Solvent Polarity and Stimuli-Responsive Properties.

To date, most of the low-molecular-weight gels are found serendipitously, and modification on known gelator structures via organic synthesis is an efficient methodology to prepare gel series. However, a simple, direct, and rational modification method for a known gelator is still a challenge. Herein, we employ Glaser coupling reaction to synthesize a novel dendrimer gelator BisDEC with the (ALS) structure, starting from terminal alkyne-based gelator DEC with the ALS structure.

Antimicrobial resistance of 3 types of gram-negative bacteria isolated from hospital surfaces and the hands of health care workers.

Background: There has been an increased focus in recent years on antimicrobial resistance of bacteria isolated from clinical samples. However, resistance of bacteria from hospital environments has been less frequently investigated.

Methods: According to hygienic standard for disinfection in hospitals, samples were collected from hospital inanimate surfaces and the hands of health care workers after daily cleaning.

Image-Guided Endoscopic Endonasal Transmaxillary Transpterygoid Approach to Meckel's Cave.

The aim of this report was to summarize our preliminary experience on the resection of tumors located in Meckel's cave via the endoscopic endonasal transmaxillary transpterygoid approach with image-guided system and to investigate the feasibility and efficacy of this approach. Two patients who had tumors in left Meckel's cave underwent surgical treatment using the image-guided endoscopic endonasal transmaxillary transpterygoid approach. This particular technique has advantages of no brain retraction, direct vision of tumor resection and protection of surrounding neurovascular structures.

Middle Turbinate Mucosal Flap in Endoscopic Skull Base Reconstruction.

Aim: To explore the indications, operation techniques and benefits of pedicled middle turbinate mucosal flap in endoscopic skull base reconstruction.

Material And Methods: The patients, who underwent endonasal endoscopic surgery from October 2009 to June 2010 in our department, were involved in this study. Multi-layer skull base reconstruction was performed in four cases by pedicled middle turbinate mucosal flap combined with fascia lata, artificial dura mater, fat and other reconstruction materials.

Endonasal endoscopic skull base multilayer reconstruction surgery with nasal pedicled mucosal flap to manage high flow CSF leakage.

Aim: Multilayer reconstruction of skull base using nasal pedicled mucosal flap has been widely accepted as a standard method for repairing high flow cerebrospinal fluid [CSF] leakage. In this study, we analyzed our outcome and summarized several valuable operation experiences from this technique.

Material And Methods: This study included 20 consecutive patients who underwent endoscopic endonasal multilayer reconstruction using a nasal pedicled mucosal flap to repair high flow CSF leakage and were available for follow-up.

Endoscopic transnasal odontoidectomy combined with posterior reduction to treat basilar invagination: technical note.

Object: Transoral microscopic odontoidectomy has been accepted as a standard procedure to treat basilar invagination over the past several decades. In recent years the emergence of new technologies, including endoscopic odontoidectomy and posterior reduction, has presented a challenge to the traditional treatment algorithm. In this article, the authors describe 1 patient with basilar invagination who was successfully treated with endoscopic transnasal odontoidectomy combined with posterior reduction.

Application of the hemi-semi-laminectomy approach in the microsurgical treatment of C2 schwannomas.

Study Design: Retrospective analysis of 9 cases of C2 schwannomas who were treated microsurgically with hemi-semi-laminectomy approach.

Objective: To review the clinical data and describe several operative nuances and pearls from our experience about the hemi-semi-laminectomy approach that provided successful resection of C2 schwannomas.

Summary Of Background Data: Compared with hemi-laminectomy, the hemi-semi-laminectomy is a more minimally invasive approach for excising spinal neurinomas, which can preserve as much of the mechanically relevant bone structures and facet joints as possible.

A solution to meningiomas at the trigone of the lateral ventricle using a contralateral transfalcine approach.

Background: Access to the trigone of the lateral ventricle is challenging because of the deep location and the intimate relationships to eloquent areas.

Methods: A novel posterior interhemispheric transfalx transprecuneus approach for two meningiomas at the trigone of the lateral ventricle is described.

Results: The meningiomas were resected completely with good neurologic outcomes and no operative mortality.

[Identification of Anaplasma phagocytophilum in small mammals from Hengduan Mountains of Southwest China].

Objective: To investigate the prevalence of Anaplasma phagocytophilum in small mammals from the forest area of Hengduan Mountains in southwestern China.

Methods: Small mammals captured from Gaoligong and Xianggelila mountainous area of Yunnan province were detected by PCR amplification. The sequences of 16S rRNA and Msp4 gene fragments from positive samples were compared with corresponding sequences deposited in GenBank.

Distribution of arboviruses and mosquitoes in northwestern Yunnan Province, China.

From July to September in 2005 and 2006, a survey was conducted to identify mosquito species and mosquito-borne arboviruses at elevations ranging from 900-3280 m between 24 degrees 00' N and 29 degrees 00' N latitude in the northwestern part of Yunnan Province, China. A total of 54,879 mosquitoes representing 15 species and 4 genera was collected using UV light traps at 59 sites. Culex tritaeniorhynchus and Anopheles sinensis were the most abundant species.