Unlike the 1p36 microdeletion syndrome, which has been extensively described, 1p36.3 microduplications have rarely been reported. We report the two siblings of familial 1p36.
View Article and Find Full Text PDFActa Neurobiol Exp (Wars)
July 2022
The current study aimed to investigate the effects of LACC1 on cognitive disorder due to stroke, as well as its underlying mechanism. LACC1 promoted inflammation and aggravated cognitive impairment in a mouse model of stroke. In an in vitro model of stroke, inhibition of LACC1 reduced inflammation and ROS‑induced oxidative stress by activating AMP‑activated protein kinase (AMPK) expression and suppressing NLPR3 expression.
View Article and Find Full Text PDFBackground/aim: This study aimed to investigate the effect and mechanism of lupeol on cerebral ischemia-reperfusion injury in rats.
Methods: The effects of lupeol on cerebral infarction, cerebral water content, neurological symptoms and cerebral blood flow in rats were evaluated. Nissl staining was carried out to assess the neuronal damage of ischemic brain after I/R in rats.