Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and inhibiting NF-κB signaling.

Aims: Cerebral aneurysm (CA) has been considered one of the most common cerebrovascular diseases, affecting millions of people worldwide. A therapeutic agent is currently missing for the treatment of CA. Nesfatin-1 (Nes-1) is an 82-amino acid adipokine which possesses a wide range of biological functions.

Monitoring and evaluation of anesthesia depth status data based on neuroscience.

Unlabelled: Monitoring and analysis of anesthesia depth status data refers to evaluating the anesthesia depth status of patients during the surgical process by monitoring their physiological index data, and conducting analysis and judgment. The depth of anesthesia is crucial for the safety and success of the surgical process. By monitoring the state of anesthesia depth, abnormal conditions of patients can be detected in a timely manner and corresponding measures can be taken to prevent accidents from occurring.

Excellent response of refractory triple-negative breast cancer to sintilimab plus chemotherapy: a case report.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a high propensity for invasion and a high incidence of lymph node metastasis. Systemic chemotherapy is considered the primary treatment for patients with TNBC; however, immune checkpoint inhibitors in addition to chemotherapy have been associated with better outcomes. Sintilimab, an anti-PD-1 antibody, was developed in China.

Empagliflozin Ameliorates Diabetic Cardiomyopathy via Attenuating Oxidative Stress and Improving Mitochondrial Function.

Diabetic cardiomyopathy (DCM) is considered to be a critical contributor to the development of heart failure. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor, has been shown to prevent cardiovascular events and reduce the incidence of heart failure in randomized clinical trials. However, the mechanism of how EMPA prevents DCM is poorly understood.

Pramipexole Protects Against Traumatic Brain Injury-Induced Blood-Brain Barrier (BBB) Dysfunction.

Traumatic brain injury (TBI) is a severe disease of brain damage accompanied by blood-brain barrier (BBB) dysfunction. The BBB is composed of brain microvascular endothelial cells (BMECs), astrocyte terminus, pericytes, and a basement membrane. Tight junction proteins expressed by BMECs play important roles in preserving BBB integrity.

Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis.

Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence.

Analysis of the Key Factors Affecting the Productivity of Coalbed Methane Wells: A Case Study of a High-Rank Coal Reservoir in the Central and Southern Qinshui Basin, China.

In the present study, three CBM blocks in the central and southern Qinshui Basin, China, including Fanzhuang, Zhengzhuang, and Changzhi blocks, were selected. Combined with the data, such as the physical properties of coal reservoirs, logging, hydrofracture operation, injection/drawdown well testing, microseismic fracture monitoring technology, and over 2000 days gas production rate, the key factors affecting the gas production rate of CBM wells were analyzed comprehensively and systematically. Unimodal and bimodal models can be identified according to the long-term gas production rate data.

Formation Environment and Development Models for the Lower Cambrian Source Rocks of the Southern North China Plate, China.

In this article, the lower Cambrian marine shale of the southern part of the Ordos basin is taken as an example to investigate the formation environment and development models of source rocks with high organic abundance in the ancient strata of the southern North China plate. The lower Cambrian shale source rocks had a thickness of 10-80 m, with high total organic carbon contents (an average of 2.68% and maximum of 9.

Indicated Prevention Interventions in the Workplace for Depressive Symptoms: A Systematic Review and Meta-analysis.

Context: Depressive symptoms are highly prevalent and cause substantive morbidities and loss of functioning among employees. Depression may be prevented at its early stages. However, there is a paucity of information regarding indicated preventive interventions for depression among employees.

Interventions for common mental health problems among university and college students: A systematic review and meta-analysis of randomized controlled trials.

Common mental health problems (CMHPs), such as depression, anxiety disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD) are internalizing disorders with high comorbidity. University and college students are under many stressors and transitional events, and students fall within the age range when CMHPs are at their developmental peak. Compared to the expanded effort to explore and treat CMHPs, there has been no a meta-analysis that comprehensively reviewed the interventions for CMHPs and examined the effects of interventions for CMHPs in college students.

Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI.

The effects of different cytochrome P450 2C19 (CYP2C19) genotypes on the prognosis of clopidogrel resistance in patients complicated with atrial fibrillation taking clopidogrel after percutaneous coronary intervention (PCI) were investigated. Eighty patients who were complicated with atrial fibrillation and treated with clopidogrel antiplatelet therapy after PCI in Meizhou Hospital Affiliated to Zhongshan University from September 2015 to January 2017 were selected, and divided into two groups according to the CYP2C19 genotype: extensive metabolism (EM) group and poor metabolism (PM) group. The related risk factors of clopidogrel resistance were determined, and the platelet aggregation rate and clopidogrel resistance rate were compared between the two groups during treatment.

Relevant and independent multi-block approach for plant-wide process and quality-related monitoring based on KPCA and SVDD.

Due to prior knowledge being often unavailable in practice, a multi-block strategy totally based on data-driven analytics is an appropriate alternative for plant-wide processes. However, most recent multi-block methods are relatively vague or insufficient for dividing up the process space and lack the comprehensive fault information for quality-related monitoring. This work intends to develop a more reasonable multi-block method and demonstrate the negative impacts of quality-unrelated variables.

The effect of transient glare on shape discrimination threshold in myopic adults.

Background: The aim was to evaluate the effect of transient glare on shape discrimination threshold (SDT) in myopic adults.

Methods: A total of 162 myopic subjects were enrolled. Of these, 121 had low to mid myopia (-1.

Physical fitness status of children and adolescents in Tianjin of China during past three decades: a cross-sectional study.

Background: Significant changes in the society and lifestyle have been observed in China, which influences the physical fitness status of children and adolescents. This study aimed to estimate the physical fitness status in Tianjin during the past three decades.

Methods: Cross sectional survey was used in this study.