Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumoniae: pharmacokinetics-pharmacodynamics combined with transcriptomic approach.

Objectives: The aim of this study was to identify the synergistic effect and mechanisms of fosfomycin (FM) combined with colistin (COL) against KPC-producing Klebsiella pneumoniae (KPC-Kp).

Methods: The bactericidal effects, induced drug resistance and cytotoxicity of FM combined with COL were evaluated by time-kill assays and mutation rate test. Time-kill assays and transcriptomics analysis were used to further clarify the mechanism of FM combined with COL.

Co-existence of two plasmids harboring transferable resistance-nodulation-division pump gene cluster, tmexCD1-toprJ1, and colistin resistance gene mcr-8 in Klebsiella pneumoniae.

Background: The emergence of plasmid-mediated mobile colistin resistance (mcr) gene poses a great challenge to the clinical application of polymyxins. To date, mcr-1 to mcr-10 have been found in animals, humans, and the environment. Among them, mcr-8 was first identified in Klebsiella pneumoniae (K.

Unraveling the pyridinic nitrogen vacancy in carbon nitride for photo-self Fenton-like purification of organic contaminants.

This work reports a carbon nitride with pyridinic nitrogen-vacancy (NV-CN), which purifies organic contaminants via an in-situ photo-self Fenton-like reaction. Experiments and calculations demonstrated that the nitrogen-vacancy induces lone-paired (LP) and symmetry-unpaired electrons, promoting the formation of low-energy LP-π hybridized orbitals and helping to overcome the pairing energy required for oxygen to accept electrons. Furthermore, the nitrogen-vacancy accelerates film and intra-particle diffusion rates of organic contaminants on NV-CN, creating beneficial conditions for reactive oxide species to mineralize organic contaminants.

The "4 + 1" strategy fabrication of iron single-atom catalysts with selective high-valent iron-oxo species generation.

Single-atom catalysts (SACs) with atomic dispersion active sites have exhibited huge potentials in peroxymonosulfate (PMS)-based Fenton-like chemistry in water purification. However, four-N coordination metal (MN) moieties often suffer from such problems as low selectivity and narrow workable pH. How to construct SACs in a controllable strategy with optimized electronic structures is of great challenge.

Selective electrophilic attack towards organic micropollutants with superior Fenton-like activity by biochar-supported cobalt single-atom catalyst.

The global shortage of freshwater and inadequate supply of clean water have necessitated the implementation of robust technologies for wastewater purification, and Fenton-like chemistry is a highly-promising approach. However, realizing the rapid Fenton-like chemistry for high-efficiency degradation of organic micropollutants (OMs) remains challenging. Herein, one novel system was constructed by a Co single-atom catalyst activating peroxymonosulfate (PMS), and the optimal system (SA-Co-NBC-0.

Photocarrier transfer induced by N → W in tungsten trioxide/carbon nitride for dual-path production of hydrogen peroxide towards ciprofloxacin degradation.

Photo self-Fenton catalyst is a promising candidate for solar energy conversion and environmental remediation. Here we reported a Tungsten trioxide/carbon nitride (WO/CN) in which the surficial amino groups on CN are inserted into the WO matrix, forming coordinate covalently N → W in construction of an intimate S-scheme heterojunction. The intimantance promotes the transfer of photocarriers under light irradiation.

Efficient and Stable Photocatalytic Hydrogen Evolution Activity of Multi-Heterojunction Composite Photocatalysts: CdS and NiS Co-modified NaNbO Nanocubes.

In this study, a NaNbO/CdS/NiS ternary composite photocatalyst containing no precious metals was successfully prepared by a simple hydrothermal method. The prepared ternary photocatalyst has a significant improvement in photocatalytic performance of hydrogen production from water splitting under visible light irradiation. The best sample NCN40% hydrogen production rate is 4.