Role of mA methyltransferase METTL3 in keratoconus pathogenesis.

Keratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (mA) modification-related proteins in KC samples and human stromal keratocyte (HTK) cells stimulated by mechanical stretch (MS) using Western blotting and immunohistochemistry.

Epoxy-rich Fe Single Atom Sites Boost Oxygen Reduction Electrocatalysis.

Electrocatalysts for highly efficient oxygen reduction reaction (ORR) are crucial for energy conversion and storage devices. Single-atom catalysts with maximized metal utilization and altered electronic structure are the most promising alternatives to replace current benchmark precious metals. However, the atomic level understanding of the functional role for each species at the anchoring sites is still unclear and poorly elucidated.

Electrochemical Carbon Dioxide Reduction to Ethylene: From Mechanistic Understanding to Catalyst Surface Engineering.

Electrochemical carbon dioxide reduction reaction (CORR) provides a promising way to convert CO to chemicals. The multicarbon (C) products, especially ethylene, are of great interest due to their versatile industrial applications. However, selectively reducing CO to ethylene is still challenging as the additional energy required for the C-C coupling step results in large overpotential and many competing products.

Modulating Electronic Structure of PtCo-Pt Nanowires with Ru atoms for Boosted Hydrogen Evolution Catalysis.

Rational design and development of highly efficient hydrogen evolution reaction (HER) electrocatalysts is of great significance for the development of green water electrolysis hydrogen production technology. Ru-engineered 1D PtCo-Pt nanowires (Ru-Pt Co NWs) are fabricated by a facile electrodeposition method. The rich Pt surface on 1D Pt Co contributes to the fully exposed active sites and enhanced intrinsic catalytic activity (co-engineered by Ru and Co atoms) for HER.

Atomically dispersed Mn atoms coordinated with N and O within an N-doped porous carbon framework for boosted oxygen reduction catalysis.

Developing efficient and robust catalysts to replace Pt group metals for the oxygen reduction reaction (ORR) is conducive to achieving highly efficient energy conversion. Here, we develop a general ion exchange strategy to construct highly efficient ORR catalysts consisting of various atomically dispersed metal atoms anchored on N-doped porous carbon (M-SAs/NC) to investigate the atomic structure-catalytic activity relationship. The structure characterization results demonstrated that the achieved atomic structure varied due to the presence of different metal centers.