Publications by authors named "Junning Case"
Article Synopsis
- Scientists studied special B cells called memory Bregs to see how they help control the immune system in healthy people and those with multiple sclerosis (MS).* -
- They found that some memory B cells could show less behavior that helps activate other immune cells, while others could actually increase inflammation.* -
- In patients with MS, the B cells were not as good at controlling immune responses compared to those in healthy individuals, which could affect how well they respond to treatments.*
Background: Parenteral anti-CD3 Mab (OKT3) has been used to treat transplant rejection and parental administration of a humanized anti-CD3 Mab (Teplizumab) showed positive effects in diabetes. Nasal administration of anti-CD3 Mab has not been carried out in humans. Nasal anti-CD3 Mab suppresses autoimmune diseases and central nervous system (CNS) inflammation in animal models.
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