Publications by authors named "Junni Xiang"
This study investigates the role of Nicotinamide N-methyltransferase (NNMT) in immune infiltration modulation through amino acid metabolism in gastric adenocarcinoma (STAD). Utilizing data from The Cancer Genome Atlas (TCGA) and validated with clinical samples, we analyzed NNMT expression and its prognostic implications in STAD. Differential amino acid profiles between cancerous and adjacent normal tissues were assessed, along with their associations with NNMT.
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- Microglia, the immune cells in the brain, play a role in neurotoxicity by releasing harmful factors and are influenced by environmental stressors like manganese (Mn) and lead (Pb).
- Exposure to both metals together causes more severe learning and memory issues in mice, linked to reduced brain-derived neurotrophic factor (BDNF) levels.
- The study reveals that mechanisms involving MeCp2 and PP2A contribute to this BDNF suppression and the harmful effects of co-exposure, along with increased inflammation in brain cells.