Publications by authors named "Junna Abe"
Kamebakaurin Suppresses Antigen-Induced Mast Cell Activation by Inhibition of FcεRI Signaling Pathway.
Int Arch Allergy Immunol
September 2024
Article Synopsis
- Kamebakaurin, derived from Rabdosia japonica and Rabdosia excisa, is explored for its potential anti-allergic effects, specifically targeting cellular mechanisms in mast cells.
- Experiments demonstrated that kamebakaurin inhibits key processes like degranulation, histamine release, and production of inflammatory mediators, showing stronger effects at higher concentrations (30 μM).
- The compound works by binding to the ATP-binding site of the Syk protein, reducing its auto-phosphorylation, which is crucial for allergy-related reactions, and it also mitigates antigen-triggered vascular hyperpermeability.