Publications by authors named "Junming Qian"
DNA methylation is a key epigenetic mechanism underlying many biological processes, and its aberrant regulation has been tightly associated with various human diseases. Precise manipulation of DNA methylation holds the promise to advance our understanding of this critical mechanism and to develop novel therapeutic methods. Previously, we were only able to alter genome-wide DNA methylation by treating with small molecules (e.
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- Rett syndrome (RTT) is a brain disorder that mostly affects girls, caused by a problem in a gene on the X chromosome.
- Researchers found a way to activate the healthy version of this gene in stem cells and neurons from RTT patients, which can help treat the disorder.
- The study showed that fixing the gene also improved brain cell size and function in RTT neurons, suggesting new ways to treat similar genetic diseases.