Ruthenium-Based Electrocatalysts for Hydrogen Evolution Reaction: from Nanoparticles to Single Atoms.

Benefiting from similar hydrogen bonding energy to Pt and much lower price compare with Pt, Ru based catalysts are promising candidates for electrocatalytic hydrogen evolution reaction (HER). The catalytic activity of Ru nanoparticles can be enhanced through improving their dispersion by using different supports, and the strong metal supports interaction can further regulate their catalytic performance. In addition, single-atom catalysts (SACs) with almost 100% atomic utilization attract great attention and the coordinative atmosphere of single atoms can be adjusted by supports.

MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation in Sepsis-Associated Acute Kidney Injury.

Introduction: Sepsis and septic shock are significant contributors to the development of acute kidney injury (AKI) in critically ill patients. This study aimed to elucidate the role and mechanism of microRNA-223-3p in sepsis-associated AKI (SA-AKI).

Methods: Bioinformatics methods were used to analyze the expression of microRNA-223-3p in sepsis patients, its correlation with inflammatory cytokines, and to predict the binding site of microRNA-223-3p with SGK1.

Salicylic Acid's impact on Sedum alfredii growth and cadmium tolerance: Comparative physiological, transcriptomic, and metabolomic study.

With the acceleration of industrialization, Cd pollution has emerged as a major threat to soil ecosystem health and food safety. Hyperaccumulating plants like Sedum alfredii Hance are considered to be used as part of an effective strategy for the ecological remediation of Cd polluted soils. This study delved deeply into the physiological, transcriptomic, and metabolomic responses of S.

PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway.

Sepsis is a severe syndrome characterized by organ dysfunction, resulting from a systemic imbalance in response to infection. PAK1 plays a critical role in various diseases. The present study aimed to explore and delineate the mechanism of PAK1 in inflammation induced by sepsis.

Hollow CoVO/Ag nanoprism with tailored electronic structure for high efficiency oxygen evolution reaction.

Developing high-active and inexpensive electrocatalysts for oxygen evolution reaction (OER) is very important in the field of water splitting. The catalytic performance of electrocatalysts can be significantly improved by optimizing the electronic structure and designing suitable nanostructure. In this work, we represent the synthesis of hollow CoVO/Ag-5 for OER.

Jasmonic acid's impact on Sedum alfredii growth and cadmium tolerance: A physiological and transcriptomic study.

Soil cadmium (Cd) pollution is escalating, necessitating effective remediation strategies. This study investigated the effects of exogenous jasmonic acid (JA) on Sedum alfredii Hance under Cd stress, aiming to enhance its phytoextraction efficiency. Initially, experiments were conducted to assess the impact of various concentrations of JA added to environments with Cd concentrations of 100, 300, and 500 μmol/L.

Ru doping induced interface engineering in flower-liked CoMoO-RuO boosts oxygen electrocatalysis for rechargeable Zn-air battery.

Constructing heterogeneous catalysts can significantly boost the electrocatalytic activity due to the improved intrinsic catalytic activity induced by tailored electronic structure and optimized chemisorption to the reaction intermediates. RuO based electrocatalysts are especially attractive due to the high catalytic activity of RuO. To reduce the usage of noble metal and improve the catalytic activity of catalyst, CoMoO-RuO micro-flower was synthesized using a facile hydrothermal-calcination method in this work.

Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C.

Malignant hyperthermia (MH) is an inherited skeletal muscle disorder caused primarily by a genetic mutation, usually in the calcium channel gene of the muscle. This mutation can lead to muscle hypersensitivity to volatile anesthetics (such as sevoflurane) and the depolarizing muscle relaxant succinylcholine, resulting in hyperthermia, muscle stiffness, metabolic disturbances, and other severe physiological reactions. This condition may prove fatal unless it is recognized in its early stages and treatment is administered promptly and aggressively.

TCF7 and LEF-1 downregulation in sepsis promotes immune suppression by inhibiting CD4 T cell proliferation.

Background: Previous studies have shown that sepsis is implicated in a reduction in the number and function of CD4 T cells. TCF7 and LEF-1 facilitate early T cell development and lineage selection of CD4 T cells. However, the function and mechanism of TCF7 and LEF-1 in sepsis are uncharacterized.

Current Progress of Mo-Based Metal Organic Frameworks Derived Electrocatalysts for Hydrogen Evolution Reaction.

As an important half-reaction for electrochemical water splitting, electrocatalytic hydrogen evolution reaction suffers from sluggish kinetics, and it is still urgent to search high efficiency non-platinum-based electrocatalysts. Mo-based catalysts such as Mo C, MoO , MoP, MoS , and MoN have emerged as promising alternatives to Pt/C owing to their similar electronic structure with Pt and abundant reserve of Mo. On the other hand, due to the adjustable topology, porosity, and nanostructure of metal organic frameworks (MOFs), MOFs are extensively used as precursors to prepare nano-electrocatalysts.

DOCK8 inhibits the immune function of neutrophils in sepsis by regulating aerobic glycolysis.

Introduction: This study endeavored to investigate the role of DOCK8 in modulating the immune function triggered by sepsis.

Methods: Expression of DOCK8 in the whole blood of sepsis patients and its enrichment pathways were assayed by bioinformatics. Pearson analysis was used to predict the relationship between glycolytic signaling pathway and its relevance to neutrophil function in sepsis.

Biochar loaded with bacteria enhanced Cd/Zn phytoextraction by facilitating plant growth and shaping rhizospheric microbial community.

Biochar and metal-tolerant bacteria have been widely used in the remediation of heavy metal contaminated soil. However, the synergistic effect of biochar-functional microbes on phytoextraction by hyperaccumulators remains unclear. In this study, the heavy metal-tolerant strain Burkholderia contaminans ZCC was selected and loaded on biochar to produce biochar-resistant bacterial material (BM), and the effects of BM on Cd/Zn phytoextraction by Sedum alfredii Hance and rhizospheric microbial community were explored.

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia.

Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown. Here, we explored the relationship between HIF-1α and PD-L1 expression in glioma, and investigated their clinical significance.

Actin Gamma 1, a new skin cancer pathogenic gene, identified by the biological feature-based classification.

Skin cancer is the most common form of cancer that accounting for at least 40% of cancer cases around the world. This study aimed to identify skin cancer-related biological features and predict skin cancer candidate genes by employing machine learning based on biological features of known skin cancer genes. The known skin cancer-related genes were fetched from database and encoded by the enrichment scores of gene ontology and pathways.

Computed tomography appearance of inflammatory myofibroblastic tumor in the abdomen: CT features and pathologic correlation.

Objective: To evaluate CT findings of abdominal inflammatory myofibroblastic tumor (IMT) and the relationship with morphological character.

Materials And Methods: CT examinations and pathological findings of ten intra-abdominal IMTs were retrospectively analyzed. The histopathological characteristics of the IMTs were confirmed by two pathologists and two radiologists evaluated CT findings of the lesion, with emphasis on the imaging features compared with the corresponding histopathology.

Blocking HMGB1 signal pathway protects early radiation-induced lung injury.

It has been reported that HMGB1 participated in various types of lung injury. In this study, we explored whether blocking HMGB1 has a preventive effect on the early radiation-induced lung injury and investigate the mechanism. Mice model of radiation-induced lung injury were accomplished by a single dose irradiation (15 Gy) to the whole thorax.

Clinical and pathological analysis of 116 cases of adult adrenal cortical adenoma and literature review.

Background: The aim of this study is to investigate origin, gross features, microscopic features, immunohistochemical properties, and differential diagnosis of adrenal cortical adenoma (ACA) in patients ≥20 years old.

Methods: The clinicopathological features of 116 cases of ACA and the immunohistochemical features of 50 cases of ACA were evaluated, and the relevant literature was reviewed.

Results: In our cohort, 76.

Prognostic significance of high-risk human papillomavirus and p16(INK4A) in patients with esophageal squamous cell carcinoma.

The prognostic value of the HPV status in ESCC is much controversial, this study aimed to determine the prognostic importance of high-risk HPV and p16 in patients with ESCC. A total of 105 consecutive patients who underwent esophagectomy in 2008 were included in this study. All specimens with ESCC were tested by in situ hybridization for HPV16/18 and immunohistochemistry for p16 expression.

Expression of interleukin-17A in lung tissues of irradiated mice and the influence of dexamethasone.

Purpose: To investigate the expressions of IL-17A in different phases of radiation-induced lung injury and the effect of dexamethasone.

Methods: The thorax of C57BL/6 mice was irradiated with 15 Gy rays. Mice from dexamethasone-treated group were injected intraperitoneally with dexamethasone (0.

Interleukin-17A antagonist attenuates radiation-induced lung injuries in mice.

Objective: To investigate the effect of interleukin-17A (IL-17A) antibodies on radiation-induced lung injuries in mice.

Methods: The thorax of 135 mice were divided into Sham (n = 30), radiation control (RC, n = 35), treatment (n = 35, IL-17A-neutralizing antibody, 4 μg/mouse, IV, 4 days per month for 4 months) and placebo group (n = 35) before a single dose irradiation (15 Gy) to the thorax. Inflammation and collagen contents in the lung tissues were examined, and the concentration of IL-17A, TGF-β1, and IL-6 in bronchoalveolar lavage fluid (BALF) were measured.

[Early high-volume hemofiltration treatment in severe sepsis].

Objective: To evaluate the effect of early application of high-volume hemofiltration treatment (HVHF) on the levels of lactic acid, pro-inflammatory cytokines and C-reactive protein (CRP) in plasma, as well as APACHE II score in patients suffering from severe sepsis.

Methods: Thirty patients meeting the diagnosis of severe sepsis were enrolled in the trial within 24 hours of insults. The level of lactic acid, interleukin-6 (IL-6) and CRP in plasma were measured before HVHF and at 24, 48 or 72 h following HVHF treatment.

Impact of acute pulmonary embolism on plasma and tissue hepatocyte growth factor: an experimental study.

This study was designed to investigate the impact of acute pulmonary embolism (PE) on plasma and tissue hepatocyte growth factor (HGF). PE was established in 16 New Zealand white rabbits by intravenous injection of autologous blood clots. Another 16 sham-operated rabbits were used as control.