Publications by authors named "Junling Mo"
UltraFast PhotoInduced double duplex DNA invasion into a 400-mer dsDNA target.
Bioorg Med Chem Lett
January 2024
Background: Natural DNA restriction enzymes bind duplex DNA with high affinity at multiple sites; however, for some of the artificial chemical-based restriction moieties, invasion of the double-strand for efficient cleavage is an obstacle. We have previously reported photo-induced double-duplex invasion (pDDI) using 3-cyanovinylcarbazole (K)-containing probes for both the target strands that photo-crosslink with pyrimidine bases in a sequence-specific manner on both the strands, stabilizing the opened double-strand for cleavage. The drawback of the pDDI was low efficiency due to inter-probe cross-linking, solved by the inclusion of 5-cyano-uridine at -1 position on the complimentary strand with respect to K in both probes.
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- Long noncoding RNAs (lncRNAs), particularly long exonic noncoding RNAs (lencRNAs), have been linked to genetic abnormalities, but their specific functions are not fully understood.
- A study employed a tethering luciferase assay to investigate five lencRNAs associated with cancer, revealing that one specific lencRNA interacts with the MED12 component of the CDK8 complex to regulate gene transcription.
- This lencRNA also influences genes related to fatty acid metabolism and promotes transcription initiation, indicating that it could modulate the activity of nearby genes post-transcription and splicing.
Hepatocyte growth factor (HGF) is a crucial factor associated with development, progression and metastasis of colorectal cancer (CRC). However, its prognostic value remains unclear. Thus studies referring to the correlation between HGF and CRC patients' prognosis were included to explore the role of HGF in CRC.
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