Deep convolutional neural networks (CNNs) have achieved impressive performance in medical image segmentation; however, their performance could degrade significantly when being deployed to unseen data with heterogeneous characteristics. Unsupervised domain adaptation (UDA) is a promising solution to tackle this problem. In this work, we present a novel UDA method, named dual adaptation-guiding network (DAG-Net), which incorporates two highly effective and complementary structural-oriented guidance in training to collaboratively adapt a segmentation model from a labelled source domain to an unlabeled target domain.
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