Publications by authors named "Junlin He"

Introduction: Although the effects of ionizing radiation on radiation workers have been extensively studied in China, no prospective cohort study has been conducted in Chongqing. Furthermore, previous cohorts have not provided a broad-gauge assessment of the temporal relationship between low-dose occupational radiation exposure and the risk of health outcomes.

Methods: A prospective cohort study will be carried out focusing on radiation workers in Chongqing.

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Objective: To characterize the subgingival microbiota in subjects with stage I/II periodontitis (moderate periodontitis, MP), stage III/IV periodontitis (severe periodontitis, SP), and periodontal health (PH) at the same probing depth (PD) (shallow ≤ 3 mm, moderate 4-6 mm, or deep ≥ 7 mm), and to investigate the changes associated with probing depth progression.

Materials And Methods: 100 subgingival plaque samples were collected from 50 subjects (16 MP, 17 SP and 17 PH), forming six groups: PHS (PH, shallow), MPS (MP, shallow), MPM (MP, moderate), SPS (SP, shallow), SPM (SP, moderate), and SPD (SP, deep). Samples were analyzed using high-throughput sequencing.

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  • * A study on mice exposed to GenX showed significant changes in placental and offspring development, including altered body and placental weights and impaired placental structure from longer exposure to GenX.
  • * The research revealed that subchronic exposure to GenX affected placental blood vessel formation and resulted in increased birth weights and premature puberty in offspring, suggesting potential health risks associated with GenX usage.
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Benzo(a)pyrene (BaP), a pervasive environmental pollutant with endocrine-disrupting properties, has been associated with detrimental effects on pregnancy. During early pregnancy, the endometrial decidualization process is critical for embryo implantation. Abnormal decidualization can lead to implantation failure, aberrant placental formation, and pregnancy loss.

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  • Cartilage injuries are common, and while bio-3D printing technology offers advantages for cartilage repair, it still has challenges like lacking blood vessel generation and biocompatibility.
  • * The study aimed to create sodium alginate-xanthan gum-hydroxyapatite (SA-XG-HA) scaffolds using 3D printing that are biodegradable and effective for repairing cartilage damage.
  • * Results showed that the composite scaffolds demonstrated strong mechanical properties, low degradation rates, and high cell activity, indicating their potential for successful cartilage regeneration.
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  • * High doses of APAP (150 mg/kg/d) in pregnant mice led to low birth weight and disrupted vascular structures in the placenta, indicating its negative impact on placental angiogenesis.
  • * The study found that APAP affects the signaling pathways in endothelial cells, specifically by increasing Suppressor of Cytokine Signaling 3 (SOCS3) levels, which disrupts crucial cellular functions needed for proper vessel formation.
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8-17 DNAzymes (8-17, 17E, Mg5, and 17EV1) are in vitro-selected catalytic DNA molecules that are capable of cleaving complementary RNAs. The conserved residues in their similar catalytic cores, together with the metal ions, were suggested to contribute to the catalytic reaction. Based on the contribution of the less conserved residues in the bulge loop residues (W, A, A) and the internal stem, new catalytic cores of 8-17 DNAzymes were programmed.

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Objectives: To investigate the effect of subacute exposure of Di (2-ethylhexyl) phthalate (DEHP) on endometrial decidualization and early pregnancy miscarriage in mice.

Methods: CD1 mice were orally administrated with 300 (low-dose group), 1000 (medium-dose group), or 3000 mg·kg·d DEHP (1/10 LD, high-dose group) for 28 days, respectively. An early natural pregnancy model and an artificially induced decidualization model were established.

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Benzo(a)pyrene [B(a)P] is an environmental endocrine disruptor with reproductive toxicity. The corpus luteum (CL) of the ovary plays an important role in embryo implantation and pregnancy maintenance. Our previous studies have shown that B(a)P exposure affects embryo implantation and endometrial decidualization in mouse, but its effects and mechanisms on CL function remain unclear.

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As a broad-spectrum and efficient insecticide, beta-Cypermethrin (β-CYP) poses a health risk to pregnancy. It matters the mechanisms of maternal exposure to β-CYP for impacting reproductive health. The placenta, a transient organ pivotal for maternal-fetal communication during pregnancy, plays a crucial role in embryonic development.

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Adverse environmental factors during maternal gestation pose a threat to pregnancy. Environmental factors, particularly nanoparticles, can impact pregnancy by causing damage to the placenta. Compared to early gestation, foetuses in late gestation are more robustly developed and at lower risk of adverse effects from environmental factors.

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Fenvalerate (FEN), a type II pyrethroid pesticide, finds extensive application in agriculture, graziery and public spaces for pest control, resulting in severe environmental pollution. As an environmental endocrine disruptor with estrogen-like activity, exposure to FEN exhibited adverse effects on ovarian functions. Additionally, the presence of the metabolite of FEN in women's urine shows a positive association with the risk of primary ovarian insufficiency (POI).

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Evidence recently showed that pleiotropic cytokine interferon-gamma (IFN-γ) in the tumor microenvironment (TME) plays a positive role in hepatocellular carcinoma (HCC) progression through the regulation of liver cancer stem cells (LCSCs) in HCC. The present study explored the role and potential mechanism of mitochondrial programmed cell death-ligand 1 (PD-L1) and its regulation of ferroptosis in modulating the cancer stemness of LCSCs. It was shown that mimicking TME IFN-γ exposure increased the LCSCs ratio and cancer stemness phenotypes in HCC cells.

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  • Acetaminophen (APAP) is commonly used to manage pain and fever in pregnant women, but research suggests it may negatively impact fetal development, specifically oocyte formation.
  • In a study, pregnant mice were given APAP, which resulted in meiotic problems in fetal oocytes, including delays in development and defects in genetic recombination due to its metabolite, NAPQI.
  • The adverse effects on oocyte health and female fertility in offspring were counteracted by co-treatment with NAD supplements, highlighting their potential therapeutic benefits during pregnancy.
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  • * This study analyzed protein expression differences in the decidual tissue of women with URSA compared to those with healthy pregnancies, revealing abnormal decidualization and identifying 146 differentially expressed proteins.
  • * The findings suggested that issues with cytoskeleton remodeling and specific transcription factors were linked to decidualization failure, which could aid in finding potential markers for diagnosing and treating URSA.
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  • Cetylpyridinium Chloride (CPC) is a disinfectant that potentially harms mitochondria, but its impacts on female reproductive health are not fully understood.
  • A study conducted on pregnant mice revealed that exposure to CPC resulted in a significant loss of oocytes in their female offspring's ovaries.
  • The research indicates that maternal CPC exposure led to mitochondrial damage and impaired oocyte development, potentially affecting fertility throughout the offspring's life.
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Decidualization is a critical process for successful pregnancy. Disorders in this process are tightly associated with adverse pregnancy outcomes including spontaneous abortion. However, the potential molecular mechanisms of lncRNAs underlying this process are yet to be fully elucidated.

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Objectives: To explore the effect of exposure to di (2-ethyl) hexyl phthalate (DEHP) in early pregnancy on endometrial decidualization in mice and its relation with lncRNA -.

Methods: Early pregnancy mice were exposed to DEHP (1000 mg·kg·d) to construct the model. The uterus was collected on day 6 of pregnancy to detect its effect on decidualization by HE staining and immunofluorescence.

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Female reproductive lifespan is largely determined by the size of the primordial follicle pool, which is established in early life. Dibutyl phthalate (DBP), a popular plasticiser, is a known environmental endocrine disruptor that poses a potential threat to reproductive health. However, DBP impact on early oogenesis has been rarely reported.

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Cationic polymeric materials and cell-penetrating peptides (CPPs) were often used as the delivery vectors in the evaluation of nucleic acid therapeutics. 10-23 DNAzyme is a kind of potential antisense therapeutics by catalytic cleavage of the disease-related RNAs. Here, lipofectamine 2000 and Tat peptide were evaluated for their effect on the catalytic activity of 10-23 DNAzyme, with the observed rate constant, thermal stability, CD spectra, and PAGE analysis, with a duplex DNA mimicking DNAzyme-substrate as a control.

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  • - Homologous recombination (HR) is crucial during early oogenesis to repair double-strand breaks (DSBs), supporting female fertility and healthy offspring, but exposure to endocrine disrupting chemicals (EDCs) like dibutyl phthalate (DBP) can lead to reproductive issues later in life.
  • - Maternal exposure to DBP disrupts meiotic prophase I in fetal oocytes, causing delays and impaired DNA damage response while still allowing efficient repair of programmed DSBs, and negatively affecting the lysine crotonylation of MSH6.
  • - The study found that changes induced by DBP exposure resulted in early activation of follicles, precocious puberty, and anxiety-like behavior in female offspring,
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Background: The biological effects of cerium dioxide nanoparticles (CeONPs), a novel material in the biomedical field, have attracted widespread attention. Our previous study confirmed that exposure to CeONPs during pregnancy led to abnormal trophoblast invasion during early placental development, thereby impairing placental development. The potential mechanisms may be related to low-quality decidualization triggered by CeONPs exposure, such as an imbalance in trophoblast invasion regulators secreted by decidual cells.

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Background: Trauma in the elderly is gradually growing more prevalent as the aging population increases over time. The purpose of this study is to assess hospitalization costs of the elderly trauma population and analyze the association between those costs and the features of the elderly trauma population.

Methods: In a retrospective analysis, data on trauma patients over 65 who were admitted to the hospital for the first time due to trauma between January 2017 and March 2022 was collected from a tertiary comprehensive hospital in Baotou.

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  • Obese women face higher risks of pregnancy complications due to issues with a process called decidualization, but the exact role of glycolysis in this problem is unclear.
  • A study with obese mice fed a high-fat diet showed they had fewer implantation sites and lower levels of proteins that aid in decidualization compared to control mice, indicating that obesity negatively impacts this process.
  • Treatments with fatty acids to simulate a high-fat environment and experimenting with glycolytic inhibitors and agonists revealed that changing glycolytic activity could influence decidualization, suggesting that obesity-related glycolysis changes might contribute to pregnancy difficulties.
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The environmental pollutant Benzo(a)pyrene (BaP) has an adverse effect on the reproductive performance of mammals. We previously showed that BaP treatment during early pregnancy damages endometrial morphology and impairs embryo implantation. Endometrial decidualization at the implantation site (IS) after embryo implantation is crucial for pregnancy maintenance and placental development.

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